Relationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial
Journal
Circulation. Cardiovascular interventions
Date Issued
2024-12
Author(s)
Reynolds, Harmony R
Page, Courtney B
Shaw, Leslee J
Berman, Daniel S
Chaitman, Bernard R
Picard, Michael H
Kwong, Raymond Y
Min, James K
Leipsic, Jonathon
Mancini, G B John
Budoff, Matthew J
Hague, Cameron J
Senior, Roxy
Szwed, Hanna
Bhargava, Balram
Celutkiene, Jelena
Gadkari, Milind
Bainey, Kevin R
Doerr, Rolf
Ramos, Ruben B
Ong, Peter
Naik, Sudhir R
Steg, Philippe Gabriel
Goetschalckx, Kaatje
Chow, Benjamin J W
Scherrer-Crosbie, Marielle
Phillips, Lawrence
Mark, Daniel B
Spertus, John A
Alexander, Karen P
O'Brien, Sean M
Boden, William E
Bangalore, Sripal
Stone, Gregg W
Maron, David J
Hochman, Judith S
ISCHEMIA Research Group
DOI
10.1161/CIRCINTERVENTIONS.123.013743
Abstract
The relationship between the extent and severity of stress-induced ischemia and the extent and severity of anatomic coronary artery disease (CAD) in patients with obstructive CAD is multifactorial and includes the intensity of stress achieved, type of testing used, presence and extent of prior infarction, collateral blood flow, plaque characteristics, microvascular disease, coronary vasomotor tone, and genetic factors. Among chronic coronary disease participants with site-determined moderate or severe ischemia, we investigated associations between ischemia severity on stress testing and the extent of CAD on coronary computed tomography angiography.