CONTEMPORARY ASPECTS IN THE PATHOGENESIS OF BRAIN EDEMA IN PATIENTS WITH HEMORRHAGIC CEREBROVASCULAR INSULT

Journal
Journal of Morphological Scienses
Date Issued
2020-07
Author(s)
Mihajlovska Rendevska, Ana
Aleksovski, B
Aleksovski, V
Mircevski, M.M
Stoev, V
Abstract
The worst neurological deterioration after hemorrhagic cerebrovascular insult (H-CVI) occurs
due to the formation of perihematomal edema, a proven significant risk factor for poor prognosis.
During the last several years, a vast number of studies have been focused on the pathogenesis of the
brain edema.
The main objective of this review paper was the evaluation of the biochemical and molecular
mechanisms involved in the pathogenesis of the edema, with a special focus on the inflammatory and
oxidative mechanisms. We believe that this brief review could serve as a motivational boost for
designing a comprehensive clinical study, in which the radiological and clinical variables, as well as
the proinflammatory mediators and the oxidative stress markers will be simultaneously evaluated for
their predictive roles in the formation of brain edema.
Subjects

hemorrhagic cerebrova...

perifocal edema

pathogenesis

proinflammatory media...

oxidative stress

File(s)
Loading...
Thumbnail Image
Name

document.pdf

Size

122.43 KB

Format

Adobe PDF

Checksum

(MD5):f87e217c1b241a26834c26333d6f263e

Loading...
Thumbnail Image
Name

cover_issue_10_en_US.png

Size

29.89 KB

Format

PNG

Checksum

(MD5):956d4c2f4ec543ca60afae77372a5df1