THE INFLUENCE OF THE LEPTIN GENE ON MILK PRODUCTION IN THREE CONSECUTIVE LACTATIONS IN HOLSTEIN FRIESIAN CATTLE
Date Issued
2025-10-02
Author(s)
Markov, Nikolay
Angeleska, Aleksandra
Abstract
This study uses a PCR method to detect allelic polymorphisms of the LEP gene. The study was
conducted among 100 Holstein cows owned by private breeders. The study was conducted on
Pelagonija farm, located in the Southwestern part of Republic of North Macedonia, over a
period of three lactations or 915 days. The research focused on the health status of the animal
and animal welfare. This study will identify all genotypes of the LEP gene and determine
associations between the polymorphism of the leptin gene and the dynamics of milk production
during three lactations of the cows. The best indicators for all three lactations will be identified
in the group of animals with the TT genotype of the LEP gene. These individuals are
characterized by increased milk yield, a high yield index and a tendency to increase the average
daily milk yield during three lactations. In cattle, the LEP gene provides instructions for
synthesizing leptin, a protein hormone predominantly expressed by white adipocytes (fat cells).
Leptin's physiological roles include the regulation of energy intake, body mass, immune
competence, and reproductive function. Its mechanism involves binding to receptors in the
lateral hypothalamus to curb appetite and to those in the medial hypothalamus to induce satiety.
Genetic variations within the LEP gene have been implicated in modulating circulating leptin
concentrations and are associated with economically significant production characteristics,
such as milk yield and quality.
conducted among 100 Holstein cows owned by private breeders. The study was conducted on
Pelagonija farm, located in the Southwestern part of Republic of North Macedonia, over a
period of three lactations or 915 days. The research focused on the health status of the animal
and animal welfare. This study will identify all genotypes of the LEP gene and determine
associations between the polymorphism of the leptin gene and the dynamics of milk production
during three lactations of the cows. The best indicators for all three lactations will be identified
in the group of animals with the TT genotype of the LEP gene. These individuals are
characterized by increased milk yield, a high yield index and a tendency to increase the average
daily milk yield during three lactations. In cattle, the LEP gene provides instructions for
synthesizing leptin, a protein hormone predominantly expressed by white adipocytes (fat cells).
Leptin's physiological roles include the regulation of energy intake, body mass, immune
competence, and reproductive function. Its mechanism involves binding to receptors in the
lateral hypothalamus to curb appetite and to those in the medial hypothalamus to induce satiety.
Genetic variations within the LEP gene have been implicated in modulating circulating leptin
concentrations and are associated with economically significant production characteristics,
such as milk yield and quality.
Subjects
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