External validation of multidimensional prognostic indices (ADO, BODEx and DOSE) in a primary care international cohort (PROEPOC/COPD cohort)
Journal
BMC Pulmonary Medicine
Date Issued
2016
Author(s)
Espantoso-Romero, Maite
Román Rodríguez, Miguel
Duarte-Pérez, Ana
Gonzálvez-Rey, Jaime
Callejas-Cabanillas, Pedro A
Lazic, Durdica Kasuba
Anta-Agudo, Berta
Torán Monserrat, Pere
Magallon-Botaya, Rosa
Lingner, Heidrun
Assenova, Radost S
Iftode, Claudia
Gude-Sampedro, Francisco
Clavería, Ana
DOI
10.1186/s12890-016-0305-2
Abstract
Due to the heterogeneous and systemic nature of the chronic obstructive pulmonary disease (COPD), the new guidelines are oriented toward individualized attention. Multidimensional scales could facilitate its proper clinical and prognostic assessment, but not all of them were validated in an international primary care cohort, different from the original ones used for model development. Therefore, our main aim is to assess the prognostic capacity of the ADO, BODEx and DOSE indices in primary care for predicting mortality in COPD patients and to validate the models obtained in subgroups of patients, classified by revised Global Initiative for Chronic Obstructive Lung Disease (2011) and updated Spanish Guideline (2014). Besides, we want to confirm that the prognostic capacity of all indices increases if the number of exacerbations is substituted by the interval between them and to assess the impact on health of the patient's lifestyle, social network and adherence to treatment.