Circulation of Crimean-Congo Hemorrhagic Fever Virus in the former Yugoslav Republic of Macedonia revealed by screening of cattle sera using a novel enzyme-linked immunosorbent assay

Mertens, Marc; Vatansever, Zati; Mrenoshki, Slavcho; Krstevski, Kiril; Stefanovska, Jovana; Djadjovski, Igor; Cvetkovikj, Iskra; Farkas, Robert; Schuster, Isolde; Donnet, Fabien; Comtet, Loic; Tordo, Noël; Ben Mechlia, Mohamed; Balkema-Buschmann, Anne; Mitrov, Dine; Groschup, Martin H

doi:10.1371/journal.pntd.0003519

Circulation of Crimean-Congo Hemorrhagic Fever Virus in the former Yugoslav Republic of Macedonia revealed by screening of cattle sera using a novel enzyme-linked immunosorbent assay

Journal

PLoS neglected tropical diseases

Date Issued

2015-03

Author(s)

Mertens, Marc

Vatansever, Zati

Djadjovski, Igor

Farkas, Robert

Schuster, Isolde

Donnet, Fabien

Comtet, Loic

Tordo, Noël

Ben Mechlia, Mohamed

Balkema-Buschmann, Anne

Groschup, Martin H

DOI

10.1371/journal.pntd.0003519

Abstract

There are only few assays available for the detection of Crimean-Congo Hemorrhagic Fever Virus (CCHFV)-specific antibodies in animals, and data about diagnostic sensitivity and specificity are incompletely documented for most of these tests. This is unfortunate since CCHFV antibodies in animals can be used as indicator for virus circulation in a geographic area and therewith potential risk of human exposure. This paper therefore reports on a novel ELISA for the detection of CCHFV-specific antibodies in cattle and on its application for testing ruminant sera from the Former Yugoslav Republic of Macedonia.

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