Serum Ca 19-9 in pancreatic adenocarcinoma: correlation with hystopathologycal characteristics and a prognostic marker for survival after curative resection

Nikolovska Trpchevska, Emilija; Popova Jovanovska, Rozalinda; Trajkovska, Meri; Nikolova, Dafina; Volkanovska, Anche

Serum Ca 19-9 in pancreatic adenocarcinoma: correlation with hystopathologycal characteristics and a prognostic marker for survival after curative resection

Journal

Macedonian Journal of Anaesthesia

Date Issued

2021-06

Author(s)

Nikolovska Trpchevska, Emilija

Abstract

Pancreatic cancer is the EU’s third biggest cancer killer, despite being the seventh most common cancer, with the extremely poor outlook for patients. CA19-9 serum levels was eval- uated as a screening tool in asymptomatic individuals and in patients with symptoms related to pancreatic cancer. The aim of the study was to correlate CA19-9 serum level in patients with pancreatic adenocarcinoma with gender, age, grade of differentiation, tumor size and tumor stage. Also, CA19-9 serum level and survival rate was determinate for the period of one year. The study included 62 patients, 40 male and 22 female with pancreatic cancer, diagnosis con- firmed by histopathological examination after surgical treatment. CA19-9 measurements were carried out at certified laboratories. The normal level of CA19-9 was 37U/ml. The patients were divided into 2 groups: the first group with increased CA19-9 level under 100U/ml and the second group with CA19-9 level over 100U/ml. Correlation between histological tumor characteristics including: tumor size, tumor stage and cell differentiation, as well as CA19-9 serum levels, re- vealed insignificant results. However, patients with elevated CA19-9 values higher than 100U/ ml were more frequently measured in patients with larger tumors, advanced III stage of tumor and poorly differentiated tumors. Our study revealed significant correlation between CA19-9 levels and patients’ gender (more in female patients than in male, 90.9% vs 62.5%), age of the patients (older patients) and survival in patients with pancreatic cancer (p=0.022).

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SERUM CA 19-9 IN PANCREATIC ADENOCARCINOMA: CORRELATION WITH HYSTOPATHOLOGYCAL CHARACTERISTICS AND A PROGNOSTIC MARKER FOR SURVIVAL AFTER CURATIVE RESECTION.pdf

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