Comparison of ZAP-70/Syk mRNA levels with immunoglobulin heavy-chain gene mutation status and disease progression in chronic lymphocytic leukemia

Laurenti, Luca; Petlickovski, Aleksandar; Rumi, Carlo; Gobessi, Stefania; Piccioni, Paola; Tarnani, Michela; Puggioni, Pierluigi; Marietti, Sara; Sica, Simona; Leone, Giuseppe; Efremov, Dimitar G

Comparison of ZAP-70/Syk mRNA levels with immunoglobulin heavy-chain gene mutation status and disease progression in chronic lymphocytic leukemia

Journal

Haematologica

Date Issued

2005-11

Author(s)

Laurenti, Luca

Rumi, Carlo

Gobessi, Stefania

Piccioni, Paola

Tarnani, Michela

Puggioni, Pierluigi

Marietti, Sara

Sica, Simona

Leone, Giuseppe

Efremov, Dimitar G

Abstract

The protein tyrosine kinase ZAP-70 has recently emerged as a major prognostic indicator in chronic lymphocytic leukemia (CLL). ZAP-70 is structurally and functionally homologous to Syk, a key mediator of B-cell receptor signaling. We therefore evaluated ZAP-70 expression in CLL B cells using Syk as an intracellular standard.