Diagnostic Value of The Ischemia Modified Albumin and Pentraxin 3 In Pediatric Appendicitis: A Meta Analysis
Journal
JOURNAL OF CLINICAL TRIALS AND EXPERIMENTAL INVESTIGATIONS (JCTEI)
Date Issued
2022-07
Author(s)
Diego Falchi
Ayten Ceren Bakir
Hani Abu Tziam
Seçil Yüksel
Sena Inal Azizoğlu
DOI
10.5281/zenodo.6857498
Abstract
Objective: In this meta-analysis, we aimed to review the diagnostic
value of pentraxin 3 (PTX3) and ischemia-modified albumin (IMA)
biomarkers in pediatric appendicitis.
Method: Studies focusing on the value of PTX3 and IMA in the diagnosis
of appendicitis were searched related to the PubMed database. Only
randomized prospective clinical trials were included in this study.
Results: After the screening, 6 articles based on the diagnostic value of
IMA in appendicitis and 5 articles on the diagnostic value of PTX3 were
reviewed. A total of 5 studies were included. The data of the 385
patients were reviewed. Sensitivity of PTX3 was 73-92% and specificity
88-100%, while IMA sensitivity was 89-96.7% and specificity was 26-
99.7% in acute appendicitis.
Conclusion: Although the results of the present study indicate that PTX3
and IMA can be shown as biomarkers in the differential diagnosis of
acute abdomen, further study is needed to determine the cut-off value
value of pentraxin 3 (PTX3) and ischemia-modified albumin (IMA)
biomarkers in pediatric appendicitis.
Method: Studies focusing on the value of PTX3 and IMA in the diagnosis
of appendicitis were searched related to the PubMed database. Only
randomized prospective clinical trials were included in this study.
Results: After the screening, 6 articles based on the diagnostic value of
IMA in appendicitis and 5 articles on the diagnostic value of PTX3 were
reviewed. A total of 5 studies were included. The data of the 385
patients were reviewed. Sensitivity of PTX3 was 73-92% and specificity
88-100%, while IMA sensitivity was 89-96.7% and specificity was 26-
99.7% in acute appendicitis.
Conclusion: Although the results of the present study indicate that PTX3
and IMA can be shown as biomarkers in the differential diagnosis of
acute abdomen, further study is needed to determine the cut-off value
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