Autoimmune thyroiditis and vitiligo in a child with minimal change nephrotic syndrome

Kuzmanovska, D B; Shahpazova, E M; Kocova, M J; Gruevska, S J; Petrushevska, G

doi:10.1007/s004670100047

Autoimmune thyroiditis and vitiligo in a child with minimal change nephrotic syndrome

Journal

Pediatric Nephrology

Date Issued

2001-12

Author(s)

Kuzmanovska, D B

Shahpazova, E M

Gruevska, S J

DOI

10.1007/s004670100047

Abstract

We report a 12-year-old child with multiple autoimmune components consisting of minimal change nephrotic syndrome (MCNS), Hashimoto's thyroiditis and vitiligo. This boy presented with MCNS, complicated by acute renal failure, and subsequently developed Hashimoto's thyroiditis and vitiligo. Conventional prednisone treatment did not induce remission, but multiple high dose infusions of methylprednisolone led to remission. The occurrence of nephrotic syndrome, Hashimoto's thyroiditis and vitiligo suggests that similar immunological mechanisms may be involved in the pathogenesis of these diseases.