Multivariable model consisting of clinical and biological markers for time to first treatment in CLL patients: Preliminary results from single centre experience

Trajkova, Sanja; Chevrevska, Lidija; Pivkova Veljanovska, Aleksandra; Ivanovski, Martin; Dukovski, Dusko; Popova-Simjanovska, Marija; Chadievski, Lazar; Eftimov, Aleksandar; Dimovski, Aleksandar; Panovska Stavridis, Irina

Multivariable model consisting of clinical and biological markers for time to first treatment in CLL patients: Preliminary results from single centre experience

Journal

Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)

Date Issued

2013

Author(s)

Ivanovski, Martin

Dukovski, Dusko

Popova-Simjanovska, Marija

Abstract

The clinical course for patients with chronic lymphocytic leukaemia (CLL) is extremely heterogeneous; one of the most important challenges in the clinical management of these patients is the decision on initiating their treatment, but there is no available prognostic system that will resolve this issue. Usually, criteria for active disease are used to initiate therapy. Recently, some authors have proposed prognostic models, scoring systems involving a set of clinical and biological risk factors and estimates of individual patient survivals. Here, we report our initial results from a study designed to evaluate the statistical association of the distinct clinical and biological parameters with the prognosis and time to initiating treatment for patients with CLL.