INFLUENCE OF PROGNOSTIC FACTORS ON OVERALL SURVIVAL IN MYELODYSPLASTIC SYNDROMES
Date Issued
2015
Author(s)
Trpkovska Terzieva, Slobodanka
Abstract
Background: Accurate prediction of a patient’s prognosis
is useful to define the risk posed by the disease.
Age, gender, peripheral blood cytopenias, proportion
of bone marrow (BM) blasts, performance status, comorbidities,
transfusion dependence, specific karyotype
abnormalities and molecular biomarkers can refine the
prediction of prognosis in MDS. Aim: to assess the influence
of the some prognostic factors like age, gender, cytopenias,
BM blast percentage, transfusion dependence,
ferritin, hemoglobin (Hb), lactate dehydrogenase (LDH),
albumin and specific karyotype abnormalities in myelodysplastic
syndromes on overall survival (OS).
Patients and Methods: we retrospectively analyzed
the cohort of 108 patients diagnosed between 1.1.2011
and 31.12.2013 at the University Clinic of Hematology,
Ss Cyril and Methodius University, Skopje, Macedonia.
They were evaluated for clinical and hematologic features
at diagnosis and at leukemic transformation. Results: in
the study group 62 were man and 46 women. Male to
female ratio was 1.35 to 1. The differences in OS between
men and women were significant (p =.03015). The mean
age at diagnosis was 66,6 years. According to the age OS
was 16,4 months. FAB subtypes influenced OS significantly
(p =.03015). OS inversely correlated with BM blast
percentage (p=.02327). Cytopenias had no impact on OS
(p=.33755). Hb as a whole and groups with different levels
of Hb had no influence on OS (p =.12142) and (p=.07535),
respectively. The group with ferritin <500 μg/L had better
OS (p=.04720). Transfusion dependence, LDH and albumin had no impact on OS. Leukemic transformation
was noticed in 10 (9,3%) patients. Mortality was 36,1%.
Conclusion: gender, FAB subtypes, BM blast percentage
and the serum levels of ferritin had an influence on
OS, while age, hemoglobin level, transfusion dependence,
LDH and albumin had no impact on OS.
is useful to define the risk posed by the disease.
Age, gender, peripheral blood cytopenias, proportion
of bone marrow (BM) blasts, performance status, comorbidities,
transfusion dependence, specific karyotype
abnormalities and molecular biomarkers can refine the
prediction of prognosis in MDS. Aim: to assess the influence
of the some prognostic factors like age, gender, cytopenias,
BM blast percentage, transfusion dependence,
ferritin, hemoglobin (Hb), lactate dehydrogenase (LDH),
albumin and specific karyotype abnormalities in myelodysplastic
syndromes on overall survival (OS).
Patients and Methods: we retrospectively analyzed
the cohort of 108 patients diagnosed between 1.1.2011
and 31.12.2013 at the University Clinic of Hematology,
Ss Cyril and Methodius University, Skopje, Macedonia.
They were evaluated for clinical and hematologic features
at diagnosis and at leukemic transformation. Results: in
the study group 62 were man and 46 women. Male to
female ratio was 1.35 to 1. The differences in OS between
men and women were significant (p =.03015). The mean
age at diagnosis was 66,6 years. According to the age OS
was 16,4 months. FAB subtypes influenced OS significantly
(p =.03015). OS inversely correlated with BM blast
percentage (p=.02327). Cytopenias had no impact on OS
(p=.33755). Hb as a whole and groups with different levels
of Hb had no influence on OS (p =.12142) and (p=.07535),
respectively. The group with ferritin <500 μg/L had better
OS (p=.04720). Transfusion dependence, LDH and albumin had no impact on OS. Leukemic transformation
was noticed in 10 (9,3%) patients. Mortality was 36,1%.
Conclusion: gender, FAB subtypes, BM blast percentage
and the serum levels of ferritin had an influence on
OS, while age, hemoglobin level, transfusion dependence,
LDH and albumin had no impact on OS.
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