INCREASE IN SERUM CYTOKINE CONCENTRATION FOLLOWING GERIATRIC HIP FRACTURE – CLINICAL RELEVANCE
Journal
Academic Medical Journal
Date Issued
2025-04-11
Author(s)
University Clinic for Traumatology, Orthopaedic Diseases, Anaesthesia, Reanimation, Intensive Care and Emergency Centre - Skopje, Republic of North Macedonia
Arsovski, Oliver
Eftimov, Ivan
Public General Hospital - Department for Orthopedics and Traumatology, Strumica, Republic of North Macedonia
Hajradinovikj, Dino
University Clinic for Traumatology, Orthopaedic Diseases, Anaesthesia, Reanimation, Intensive Care and Emergency Centre - Skopje, Republic of North Macedonia
DOI
10.53582/AMJ2551119s
Abstract
Introduction: Hip fractures are the most common operatively treated skeletal injuries, predominantly affecting individuals over 65 years of age who often have multiple comorbidities. A global increase in hip fracture incidence has been observed, accompanied by unfavorable outcomes, including reduced life expectancy. This study aimed to analyze the inflammatory response after hip fracture and surgery in patients aged over 65 years, and its association with functional outcomes.
Methods: This prospective, non-randomized study included patients with AO type 31A and 31B hip fractures admitted for surgical treatment. Eligible participants had demographic and clinical parameters recorded, including ASA scores, pharmacological therapy, and Katz Index scores. Blood samples were collected at four time points: within 10 hours post-injury, 48-60 hours post-surgery, on postoperative day seven, and day 30. Laboratory analyses included IL-1β, IL-6, and IL-10 levels. Follow-up data, including survival, mobility, pain, and quality of life (SF-12), were collected at 12 months.
Results: The study included 40 patients (median age: 78 years; 60% female). By the 12-month follow-up, 32 participants survived, while 8 died within 4-9 months. Deceased patients had significantly higher serum levels of IL-1β, IL-6, and IL-10 at all time-points. IL-6 was identified as an independent predictor of reduced mobility (p=0.013) and quality of life (p=0.009).
Conclusion: Elevated serum inflammatory markers were associated with poorer quality of life, mobility, and survival. These findings suggest potential for targeted rehabilitation programs and preventive strategies to improve outcomes in geriatric hip fracture patients.
Methods: This prospective, non-randomized study included patients with AO type 31A and 31B hip fractures admitted for surgical treatment. Eligible participants had demographic and clinical parameters recorded, including ASA scores, pharmacological therapy, and Katz Index scores. Blood samples were collected at four time points: within 10 hours post-injury, 48-60 hours post-surgery, on postoperative day seven, and day 30. Laboratory analyses included IL-1β, IL-6, and IL-10 levels. Follow-up data, including survival, mobility, pain, and quality of life (SF-12), were collected at 12 months.
Results: The study included 40 patients (median age: 78 years; 60% female). By the 12-month follow-up, 32 participants survived, while 8 died within 4-9 months. Deceased patients had significantly higher serum levels of IL-1β, IL-6, and IL-10 at all time-points. IL-6 was identified as an independent predictor of reduced mobility (p=0.013) and quality of life (p=0.009).
Conclusion: Elevated serum inflammatory markers were associated with poorer quality of life, mobility, and survival. These findings suggest potential for targeted rehabilitation programs and preventive strategies to improve outcomes in geriatric hip fracture patients.
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