Davcheva, Natasha

Preferred name

Davcheva, Natasha

Official Name

Davcheva, Natasha

Alternative Name

Davceva Natasha

Davceva N

Davcheva N

Main Affiliation

natasha.davceva@medf.ukim.edu.mk

drdavcevamk@yahoo.com

Scopus Author ID

26040668900

Researcher ID

E-cris 04391

SICRIS (slovenia) 40500

Now showing 1 - 10 of 64

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Reliable and durable Golgi staining of brain tissue from human autopsies and experimental animals
(Elsevier BV, 2014-06-15)
Rosoklija, Gorazd B
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Petrushevski, Vladimir M
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Dika, Ani
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Golgi stains are notoriously capricious, particularly when applied to human brain. The well-known difficulties, which include complete failure of impregnation, patchy staining, unstable staining, and extensive crystalline deposits in superficial sections, have discouraged many from attempting to use these techniques. A reliable method that produces uniform impregnation in tissue from human autopsies and experimental animals is needed.
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Unusual cause of death in a patient with Covid-19
(Springer, 2021-09)
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Dzengis, Jasar
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Hemispheric asymmetry of the superior temporal cortex in postmortem schizophrenic and control brains
(Elsevier BV, 2003-03)
Smiley, J.F.
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Dwork, A.J.
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Mancevski, B.
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Duma, A.
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Acute corrosive poisonings - Frequent cause for fatal outcome
(Elsevier BV, 2018-10)
Chibishev, Andon
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Shikole, Emilija
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Bozinovska, Cvetanka
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Comment to the article: beta-APP immunoreactivity as diagnostic tool of Diffuse Axonal Injury (DAI)
(Romanian Society of Legal Medicine, 2012-09)
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НЕВРОМОРФОЛОГИЯ И СЪДЕБНОМЕДИЦИНСКО ЗНАЧЕНИЕ НА ДИФУЗНАТА АКСОНАЛНА ЛЕЗИЯ
(Българска Академия на Науките, 2014)
NEUROMORPHOLOGY AND FORENSIC SIGNIFICANCE OF DIF-FUSE AXINAL LESION Summary With the introduction of the concept of focal and diffuse brain injuries in the past 20 years, it became clear that the outcome of a head injury does not depend so much on the extensity of the focal injury, as on the occurrence of diffuse brain injuries. Diffuse axonal injury (DAI) is a clinical-pathological entity clinically characterized by an immediate and prolonged unconsciousness after a mechanical impact to the head, typically without any lucid interval, lead-ing to severe brain failure, vegetative state and death, and pathologically de-fined by a diffuse damage of axonal fibres inside the white matter, including the fibre tracts and the brain stem. The aim of the present thesis is to perceive the incidence and distribu-tion of DAI in the overall pathology of closed head injuries, and to emphasize the significance of the complete forensic-neuropathological examination (FNE) in the process of its diagnosis. For this aim, we analyzed the appearance and distribution of DAI on 63 cases with fatal non-missile head injury. To all in-cluded cases a complete FNE was performed. According to our results, DAI has an incidence of about 30-50% in the pathology of the closed head injury. It is an acceleration-deceleration injury that typically occurs in road traffic accidents and in the falls from a consider-able height (above 2 meters) but is not typical for the cases of simple falls or assaults. Therefore, DAI is more characteristic for the traumatic events related with a longer duration of the acceleration forces, whereas the other acceleration injury – the acute subdural hematoma (ASDH) is more characteristic for the events with short duration of the acceleration forces. There is no statistically significant simultaneous occurrence of DAI and ASDH. Furthermore, DAI as a sole feature and the only explanation for the impairment of the brain function and also, as the cause of death, can be found in every fifth case of closed head injury and its presence can be detected only by a complete FNE. The most con-stant clinical parameter accompanying DAI is the immediate and deep coma. Our study revealed a clear correlation between the coma and the damage of axonal fibres of both traumatic and ischemic origin. By exploring the clinical-pathological correlations of DAI, we showed that DAI is not a significant factor to the short survival (i.e. to the fatal outcome) in the first 24 hours, but is a sig-nificant factor for the severity of the impairment of brain function. This finding is of a huge medico-legal importance. On the other hand, a verified presence of DAI upon the FNE, is an absolute sign of a vital reaction, and also for the time of survival of at least 2-3 hours. Finally, ß-APP immunohistochemistry proved to be an important tool in hands of the forensic neuropathologist which cer-tainly demonstrates that: there has been the injury of the brain; the origin of the axonal damage (is it traumatic or ischemic) and that the injury has occurred intra-vitaly, which is of a big medico-legal relevance. Also, the time course of the axonal pathology revealed by ß-APP expression can point to the age of the injury, which is also of a huge significance for forensic medicine.
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Објективноста на вештачењето - основно начело на лекарот-вештак
(Македонско Лекарско Друштво, 1999-10)
Duma, Aleksej
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Gutevska, A.
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A novel mechanism and treatment target for presynaptic abnormalities in specific striatal regions in schizophrenia
(Springer Science and Business Media LLC, 2010-04)
Barakauskas, Vilte E
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Beasley, Clare L
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Barr, Alasdair M
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Ypsilanti, Athena R
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Li, Hong-Ying
Abnormalities of amount and function of presynaptic terminals may have an important role in the mechanism of illness in schizophrenia. The SNARE proteins (SNAP-25, syntaxin, and VAMP) are enriched in presynaptic terminals, where they interact to form a functional complex to facilitate vesicle fusion. SNARE protein amounts are altered in the cortical regions in schizophrenia, but studies of protein-protein interactions are limited. We extended these investigations to the striatal regions (such as the nucleus accumbens, ventromedial caudate (VMC), and dorsal caudate) relevant to disease symptoms. In addition to measuring SNARE protein levels, we studied SNARE protein-protein interactions using a novel ELISA method. The possible effect of antipsychotic treatment was investigated in parallel in the striatum of rodents that were administered haloperidol and clozapine. In schizophrenia samples, compared with controls, SNAP-25 was 32% lower (P=0.015) and syntaxin was 26% lower (P=0.006) in the VMC. In contrast, in the same region, SNARE protein-protein interactions were higher in schizophrenia (P=0.008). Confocal microscopy of schizophrenia and control VMC showed qualitatively similar SNARE protein immunostaining. Haloperidol treatment of rats increased levels of SNAP-25 (mean 24%, P=0.003), syntaxin (mean 18%, P=0.010), and VAMP (mean 16%, P=0.001), whereas clozapine increased only the VAMP level (mean 13%, P=0.004). Neither drug altered SNARE protein-protein interactions. These results indicate abnormalities of amount and interactions of proteins directly related to presynaptic function in the VMC in schizophrenia. SNARE proteins and their interactions may be a novel target for the development of therapeutics.
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Measurement-oriented deep-learning workflow for improved segmentation of myelin and axons in high-resolution images of human cerebral white matter
(Elsevier BV, 2019-10)
Janjic, Predrag
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Petrovski, Kristijan
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Dolgoski, Blagoja
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Smiley, John
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Background: Standard segmentation of high-contrast electron micrographs (EM) identifies myelin accurately but does not translate easily into measurements of individual axons and their myelin, even in cross-sections of parallel fibers. We describe automated segmentation and measurement of each myelinated axon and its sheath in EMs of arbitrarily oriented human white matter from autopsies. New methods: Preliminary segmentation of myelin, axons and background by machine learning, using selected filters, precedes automated correction of systematic errors. Final segmentation is done by a deep neural network (DNN). Automated measurement of each putative fiber rejects measures encountering pre-defined artifacts and excludes fibers failing to satisfy pre-defined conditions. Results: Improved segmentation of three sets of 30 annotated images each (two sets from human prefrontal white matter and one from human optic nerve) is achieved with a DNN trained only with a subset of the first set from prefrontal white matter. Total number of myelinated axons identified by the DNN differed from expert segmentation by 0.2%, 2.9%, and -5.1%, respectively. G-ratios differed by 2.96%, 0.74% and 2.83%. Intraclass correlation coefficients between DNN and annotated segmentation were mostly>0.9, indicating nearly interchangeable performance. Comparison with existing method(s): Measurement-oriented studies of arbitrarily oriented fibers from central white matter are rare. Published methods are typically applied to cross-sections of fascicles and measure aggregated areas of myelin sheaths and axons, allowing estimation only of average g-ratio. Conclusions: Automated segmentation and measurement of axons and myelin is complex. We report a feasible approach that has so far proven comparable to manual segmentation.
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Consistent loss of subicular dendritic spines in schizophrenia and mood disorders
(Oxford University Press, 2005)
Dwork AJ
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Manchevski B
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Rauski S
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Serafimova T
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Davcheva, Natasha

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