Dimitrova shumkovska, Jasmina
Preferred name
Dimitrova shumkovska, Jasmina
Official Name
Dimitrova shumkovska, Jasmina
Main Affiliation
Email
jasminad@pmf.ukim.mk
7 results
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Item type:Publication, ADRENAL GLAND TLR EXPRESSION IN ApoE DEFICIENT HOMOZYGOUS (ApoE KO-/-) MICE WITH IMPAIRED THYROID FUNCTION(Macedonian Association of Anatomists and Morphologists, 2023-12); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, APPLICATION OF THE SINGLE CELL GEL ELECTROPHORESIS FOR DETECTION OF OXIDATIVE DNA DAMAGE DUE TO LONG TERM EXPOSURE TO SUPRAPHYSIOLOGIC DOSES OF L-THYROXINE(Macedonian Association of Anatomists and Morphologists, 2018); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Effects of different dietary fatty acids supplements upon lipid peroxides production in rats tissues with different phospholipid composition(Faculty of Natural Sciences and Mathematics, "Ss Cyril and Methodius" in Skopje - Institute of Biology, 2004); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Thyroid hormone levels and morphometric specifics of thyroid gland in ApoE deficient (ApoE KO) mice(Veterinary Faculty of the University of Ljubljana, Slovenia., 2014); ; ; ; The specificity of biological features in strains used as animal models is of particular importance of the interpretation of experimental data. In this paper we examine thyroid hormones levels as well as diameter of thyroid follicles and the follicular epithelium height in ApoE-knockout (ApoE KO) mice, compared to the wild type (WT) - C57BL/6 strain as a control group. ApoE lipoprotein deficiency in this strain leads to development of severe hypercholesterolemia and atherosclerotic lesions in the blood vessels, even when mice are fed regular mouse chow. The results of our study revealed difference in FT3 plasma level between the two strains of mice with no significant difference in FT4 level. The morphometric analysis showed a significantly higher follicular epithelium in ApoE KO mice compared to the wild strain, which is an indication of greater TSH stimulation in ApoE KO strain. Regarding the diameter of thyroid follicles, our results corroborate no significant differences between the genetically modified animal strains, which are consistent with previous data from other studies that found no correlation of the above mentioned parameter with thyroid status of animals. The difference in thyroid function between the two strains of experimental animals could be due to altered peripheral metabolism of thyroid hormones, a consequence of the altered liver physiology in ApoE KO mice. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Erythrocyte glucose-6-phosphate dehydrogenase activity in laboratory rats treated with amoxiclav, lidaprim and 1-chloro-2,4-dinitrobenzen. Preliminary communication.(Македонска академија на науките и уметностите, Одделение за биолошки и медицински науки = Macedonian Academy of Sciences and Arts, Section of Biological and Medical Sciences, 2005); ; The enzyme glucose-6-phosphate dehydrogenase (G6P–DH, EC.1.1.1.49) catalyzes the oxidation of glucose-6-phosphate in 6-phosphogluconat which is indispensable in the defence of erythrocytes from oxidative insult. The aim of this study was to examine the influence of commonly used drugs in our medical practice, amoxiclav (amoxicillin-clavulanate combination) and lidaprim (trimethoprim-sulfamethrole combination) respectively, upon the erythrocyte G6P-DH activity in experimental rats. In addition, the effect of the toxic drug 1-chloro-2,4-dinitrobenzen (CDNB) on the activity of G6P-DH was examined. The experiment was conducted in fresh blood haemolysates of white laboratory rats, Wistar type, of both genders (n = 80). The enzyme activity was determined by “Boehringer-Mannheim” diagnostic assay kits (Kornberg et al., 1955). However, the measured enzyme activity in the control group of rats was found to be a statistically insignificant difference between the genders (140.2 ± 21.2 mU/109 Er in male rats, 144.3 ± 20.6 mU/109 in the female group). Hence, the established enzyme activity does not differ from the activity of the same enzyme in healthy human subjects. The administered dose of lidaprim did not affect the activity of G6P-DH in the treated group of rats, thus attaining levels similar to the control group. By contrast, amoxiclav administration provoked a significant reduction in enzyme activity of 13.6% in male and 19.5% in female rats (p < 0.001), while the treatment with CDNB significantly increased the activity of the latter to 49.7% in male and 30.1% in female rats (p < 0.001) in comparison with the control ones. Testing of haemolitical potential is strongly recommended prior to the use of new drugs, particularly in the Mediterranean region, were this enzymopathy is found to be frequent bearing in mind that there is an established list of drugs which affect the G6P-DH activity in the erythrocytes. The above-mentioned method may be used in experimental animal models allowing for administration of a wider selection of drugs in this type of research. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Effects of different dietary fatty acid supplements upon lipoprotein metabolism and lipid peroxides production in hyperlipidemic rats.(Македонска академија на науките и уметностите, Одделение за биолошки и медицински науки = Macedonian Academy of Sciences and Arts, Section of Biological and Medical Sciences, 2006); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, 64CU-COMPLEX OF THE BIFUNCTIONAL CHELATOR WITH PSMA TARGETING MOLECULE IN EX VIVO BIODISTRIBUTION STUDY IN HEALTHY RATS(Macedonian Medical Association, 2021);