Orovchanec, Nikola
Preferred name
Orovchanec, Nikola
Official Name
Orovchanec, Nikola
Main Affiliation
Email
novovodno@gmail.com
7 results
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Item type:Publication, Hyperhomocysteinemia and the Methylenetetrahydrofolate Reductase (C677T) Genetic Polymorphism in Patients with Deep Vein Thrombosis(ScopeMed Publishing, 2013); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Clinical Significance of Quantitative HBs Antigen in the Prediction of Liver Fibrosis in Patients with Chronic Hepatitis B(Macedonian Academy of Sciences and Arts, 2018-07); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Epidemiological and clinical characteristics of patients with Basal cell carcinoma (BCC) in the eyelid(2011); ; ; Itroduction:BCC is a malignant cutaneous neoplasm capable of extensive tissue destruction. BCC rarely metastasises. BCC is the most common skin cancer of the eyelid, accounting for 80-89% of cases Aim: To describe the epidemiological and clinical characteristics of patients with eyelid BCC. Methods: Epidemiological data of BCC in the eyelid has been collecting from Clinic of ophthalmology-Skopje. The data of all cases of Macedonian residents with eyelid BCC diagnosed from 2007 to 2009y. were retrieved for analysis. We analyzed sex and age distribution, localization, dimension and type of BCC in the eyelids Results: BCC is slightly more common in males than in females with a male-to-female ratio of 2:1. more of them are male-67% and female-33%, differences was statistical significant-p<0,05. There were not statistical significant association(p>0,05) between gender and BCC. The percents of BCC increase with advancing age and tend to occur in the seventh decade of life. The mean age is 68,03±10,8y. Approximately 72% of cases of BCC occur in the patients aged over 60y. There were statistically significant differences between urban (32%) and rural (68%) populations. The most frequent histological subtype was nodular(52%), followed by superficial(17%) and 71% belongs to the squamous cell, followed by kerotic cells-13%.Localisation of BCC was mainly on the lower eyelid-49%, and the medial canthal region-27%, but involved the right and left sides with equal frequency.. In 59% of the cases, the diameter of the lesion was smaller than 11mm. Conclusion: These expanded epidemiological characteristics may serve to provide a foundation to monitor future disease patterns and to promote further research into the a etiology of these cancers. All patients with lesions should be advised of the risk of recurrent or new BCC , a biopsy of all suspicious lesions followed by complete surgical excision with microscopic monitoring of the margins has the best chance for cure.. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Influence of gender, inheritance factor and age in glaucoma occurrence and progress(SHMSHM - AAMD, 2020); INTRODUCTION: Glaucoma, one of the leading causes of irreversible blindness in the elderly population worldwide, is a progressive optic neuropathy. Risk factors for glaucoma have been explored and published in many studies. Elevated intraocular pressure (IOP) is, as is well known, the highest risk for glaucoma. Studies show that reducing IOP reduces the risk of developing the disease or slows the progression of glaucoma. There is growing evidence that other risk factors such as age, sex, race, refraction, heredity, and systemic diseases play a role in the pathogenesis of glaucoma. The risk factors for glaucoma can be divided into systemic and local. Systemic risk factors are blood pressure: hypotension or hypertension, vasospasm, diabetes, chronic heart disease, hypercholesterolemia, thyroid disease, etc. Local risk factors are parapapillary atrophy, intraocular pressure, papillary excavation, certain diseases of the anterior or posterior segment of the eye, central corneal thickness, fluctuations in IOP, etc. RESOURCES AND METHODS: A case-control study was performed, which included patients aged 25 to 70.The study was conducted at the Clinic for Eye Diseases, in Skopje, in the Glaucoma Cabinet, in the period from 2015-2019.The study included 100 patients, who were divided into two groups. About the patients in the study, a comprehensive medical history was made, as well as a history of the condition, age, sex, family history, hereditary factor, and whether the patient was using anti glaucoma therapy. RESULTS: In determining the significance of the contribution to the prediction of glaucoma, it was found that the age of the patients had the greatest influence (Wald = 5.05 / p <0.05 (p = 0.025), followed by the family history (Wald = 0.04 / p> 0 , 05 (p = 0.84) and the weakest is the influence of the sex of the patients (Wald = 0.01 / p> 0.05 (p = 0.94) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Immunohistochemical Expression of Epidermal Growth Factor Receptor in Hepatocellular Carcinoma(Macedonian Academy of Sciences and Arts/Sciendo, 2018-12-01); ; ; Epidermal growth factor receptor (EGFR) signaling plays an important role in various cancers, including hepatocellular carcinoma (HCC). We aimed to evaluate immunoexpression of EGFR in HCC and surrounding non-tumor liver tissue and to correlate it to multiple clinicopathologic data. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, PREDICTIVE VALUE OF TIME FROM VACCINATION TO DELIVERY AT PERINATAL OUTCOME IN PATIENTS PREVIOUSLY VACCINATED AGAINST COVID-19(SHMSHM - AAMD, 2023); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The influence of myopia on visual field changes in patients with and without glaucoma(Македонско лекарско друштво = Macedonian medical association, 2020); Introduction. Glaucoma, one of the leading causes of irreversible blindness in the elderly population world- wide, is a progressive optic neuropathy. Myopia or near sightedness is a refractive anomaly in which parallel rays of light coming from a distance after refraction through the cornea and lens focus in front of the retina in the vitreous and then in a state of divergence create scatte- red circles on the retina. The visual field is a projection of the functional part of the retina in space, i.e. a pro- jection of all retinal points at which visible sensations can begin. If there is a damage to the nerve fibers of the retina, a decrease or absence of sensitivity to identical stimuli is manifested by defects in the visual field. Methods. The study included 100 patients, who were divided into two groups: one group with glaucoma and another group without glaucoma. Regarding the degree of myopia, all subjects (with and without glaucoma) were divided into 3 groups: Low from-1Diopt to-3Diopt, Me- dium from -3 Diopt to -6 Diopt and High>-6 Diopt. A visual field was made in each patient. Results. The cross tabulation showed in the examined group (glaucoma) and the control group (no glaucoma) for Fisher's Exact Test=28.920 and p<0.001 (p=0.000) /Monte Carlo Exact Sig. (2-sided)/0.000-0.000/. There was a significant difference between the two groups in terms of visual field (finding). For Fisher's Exact Test =31,157 ip <0.001 (p=0.000)/MonteCarloSig. (2-sided) /0.000-0.001 in the performed cross tabulation between the height of myopia and the degree of changes in the visual field, there was a significant difference. Conclusion. There was a significant difference shown in the performed cross tabulation between the height of myopia and the degree of changes in the visual field.