Stefova, Marina

Preferred name

Stefova, Marina

Official Name

Stefova, Marina

Main Affiliation

marinaiv@pmf.ukim.mk

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Phenolics and mineral content in bilberry and bog bilberry from Macedonia
(Informa UK Limited, 2017-07-18)
Stanoeva, Jasmina Petreska
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Andonovska, Katerina Baceva
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Vankova, Ana
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Stafilov, Trajce
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Polyphenols and Minor Constituents in Honey from North Macedonia and Bulgaria
(Prof. Marin Drinov Publishing House of BAS (Bulgarian Academy of Sciences), 2022-03-02)
Bogojovska, Martina
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Bankova, Vassya
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Popova, Milena
Honey is a highly concentrated sugar solution that is a rich source of many bioactive compounds including numerous minor constituents. Among them, polyphenols such as flavonoids and phenolic acids are the most important classes of pharmacologically active compounds. Together with other minor constituents they are also considered potential chemical markers for the botanical and geographical origin of honey as well as for its authenticity. A solid-phase extraction procedure and HPLC/DAD/MSn method has been applied for identification and quantification of minor constituents in honey from the region of Bulgaria, North Macedonia, and Greece. Solid-phase extraction using Amberlite XAD-2 as an adsorbent was used for sample preparation enabling purification and concentration of the analysed compounds, mainly polyphenols. In total, 16 compounds were identified in the 21 extracts, 3 of them hydroxycinammic acids (caffeic, p-coumaric and ferulic acid), 5 flavonoids (naringenin, chrysin, galangin, pinocembrin and pinobanksin methyl ether) as well as gluconic acid, quinic acid, ascorbic acid, phenyllactic acid, kynurenic acid and abscisic acid in its two isomeric forms. Quantification of the identified polyphenols was made by an external calibration. The results showed that the developed method presented here is suitable for obtaining qualitative and quantitative data for polyphenols of honey.
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Callus cultures of Hypericum perforatum L. a novel and efficient source for xanthone production
(Springer Nature, 2016-01-23)
Tusevski, Oliver
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Stanoeva, Jasmina Petreska
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Markoska, Elizabeta
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Brndevska, Natasa
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Chemical characterization of Centaurium erythrea L. and its effects on carbohydrate and lipid metabolism in experimental diabetes
(Elsevier BV, 2014-02-27)
Stefkov, Gjoshe
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Dinevska-Kjovkarovska, Suzana
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Stanoeva, Jasmina Petreska
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Centaurium erythrea L. fam. Gentianaceae (CE) has been traditionally used for centuries in folk medicine of Balkans as a bitter medicinal herb for digestive complications and for treating febrile conditions and diabetes. The aim of this study was to gain insight into the chemical composition and underlying biochemical mechanism of action of the antihyperglycemic and antilipidemic activities of the dry extract of Centaurium erythrea L., wildly growing and traditionally used medicinal plant in the Republic of Macedonia.
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Volatile Composition of Macedonian and Hungarian Wines Assessed by GC/MS
(Springer Science and Business Media LLC, 2012-01-05)
Ivanova, Violeta
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Vojnoski, Borimir
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Stafilov, Trajče
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Bíró, Ildiko
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HPLC and UV-spectrophotometry analysis of flavonoids in spray-dried and freez-dried extracts of Teucrium polium L. (Lamiaceae)
(Macedonian Pharmaceutical Association, 2012-09)
Stefkov, Gjoshe
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Bankova, Vassya
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<jats:p>Тhe aim of the study was identification and determination of the content of flavonoids in dry extracts of Teucrium polium, collected from Republic of Macedonia. Two different drying procedures were used, freeze and spray draying. In freeze-dried (FDE) and spray-dried (SDE) extracts of aerial parts of T. polium five flavone aglycones (luteolin, apigenin, cirsiliol, cirsimaritin and cirsilineol) were identified by HPLC method, on the base of retention times and UV spectral data of the components of the extracts in comparison to the authentic samples of flavonoids. Additionally, seven glycosides of apigenin and luteolin were tentatively identified. No significant differences in the composition nor in the content of identified flavonoids were found between both extracts. The content of total flavonoids determined by UV-spectrophotometry with AlCl3 was 72.8 ± 0.62 mg Lut/g and 73.34 ± 0.53 mg Lut/g in FDE and SDE extract of T. polium, respectively.</jats:p>
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State of antioxidant systems and phenolic compounds’ production in Hypericum perforatum L. hairy roots
(Springer Science and Business Media LLC, 2019-07-09)
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Spasenoski, Mirko
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Gadzovska Simic, Sonja
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Flavonoids and Other Phenolic Compounds in Needles of Pinus peuce and Other Pine Species from the Macedonian Flora
(SAGE Publications, 2015-06)
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Stefkov, Gjose
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Stanoeva, Jasmina Petreska
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<jats:p> Flavonoids and other phenolic compounds in young needles of four pine species, Pinus peuce, P. nigra, P. mugo and P. sylvestris from the Macedonian flora were investigated. The amount of total phenols and total flavonoids were determined using Folin-Ciocalteau and aluminum chloride assay, respectively. The obtained results revealed that the total phenolic content (TPC) and total flavonoids content (TFC) varied among different pine species ranging from 9.8 to 14.0 mg GAE/g and from 3.3 to 7.2 mg CE/g of dried plant material, respectively. Qualitative analysis of flavonoids and other phenolic components was made by a LC-DAD/ESI-MS<jats:sup>n</jats:sup> optimized chromatographic method. A total of 17 phenolic components were identified and classified as: acids (2), procyanidins (2) and flavonoid glycosides (13). The most prevalent components were flavonoid glycosides, especially flavonols and methylated flavonols (9). Additionally, 3 components were found as acylated flavonol glycosides with ferulic and p-coumaric acid. The last one was found not only in esterified form but also in the free form. Only one flavone-apigenin glycoside was detected. Procyanidins were identified as catechin derivatives, both dimers and trimers. </jats:p>
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HPLC-DAD-ESI-MSn identification of phenolic compounds in cultivated strawberries from Macedonia
(Society of Chemists and Technologists of Macedonia, 2010-12-15)
Kajdžanoska, Marina
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Gjamovski, Viktor
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<jats:p>Strawberry fruits contain phenolic compounds that exhibit antioxidant, anticancer, antiatherosclerotic, antinflammatory and anti-neurodegenerative properties. High-performance liquid chromatography (HPLC) coupled to electrospray ionization mass spectrometric (ESI-MS) detection in the positive and negative ion mode has been used to identify the phenolic compounds in extracts from sixteen different strawberry cultivar fruits from Republic of Macedonia. Photodiode-array detection (DAD) has been used for screening of the different classes of phenolic compounds, whereas MS and MSn fragmentation data were employed for their structural characterization. The phenolic compounds identified were grouped as: ellagic acid and ellagic acid conjugates with sugars, ellagitannins, anthocyanins, flavonols, flavanols, and acylated sugars (feruloyl, caffeoyl and coumaroyl hexoses). Quercetin and kaempferol were the major flavonols found as quercetin 3-O-glucoside, quercetin 3-O-glucuronide, kaempferol 3-O-glucoside, kaempferol 3-O-glucoronide, kaempferol 3-O-malonylglucoside, kaempferol 3-O-acetylglucoside and kaempferol 3-O-coumaroylglucoside. Pelargonidin-3-O-glucoside was the most abundant anthocyanin in all strawberry extracts. Proanthocyanidins were also identified by MSn fragmentation as dimers, trimers and tetramers of (epi)catechin and (epi)afzelechin. This is the first assay of the phenolic profile of the strawberry cultivars in Macedonia, which can be further developed for characterization and evaluation of their quality with regards to their phenolic composition.</jats:p>
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Assay of urinary excretion of polyphenols after ingestion of a cup of mountain tea (Sideritis scardica) measured by HPLC-DAD-ESI-MS/MS
(American Chemical Society (ACS), 2013-11-06)
Petreska Stanoeva, Jasmina
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Flavonoids and phenolic acid metabolites excreted in human urine after ingestion of Sideritis scardica decoction with characterized polyphenolic composition were studied. A feeding study was carried out with 10 human volunteers, and urine samples were collected for 24 h after ingestion of the Sidertis decoction. Polyphenol metabolites were identified and quantified in urine samples by HPLC with tandem mass spectrometric detection. Thirty-one different metabolites of hypolaetin, methylhypolaetin, isoscutellarein, methylisoscutellarein, and apigenin and 32 phenolic acid metabolites were detected and quantified using a method validated for this purpose. The urinary excretion of polyphenol metabolites corresponded to 5% (n/n) of the intake of polyphenols from the Sideritis decoction. Flavonoid metabolites were dominant in urine samples with 87-94% of total polyphenolic metabolites content. The most abundant metabolites were methylhypolaetin and methylisoscutellarein glucuronides. Urinary excretion of isoscutellarein (35.61%) was 10 times higher than that of hypolaetin (3.67%). Apigenin also showed high urinary excretion (32.46%).

Stefova, Marina

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