Daneva Markova, Ana
Preferred name
Daneva Markova, Ana
Official Name
Daneva Markova, Ana
Alternative Name
Daneva Ana
Markova Daneva Ana
Данева Ана
Маркова Данева Ана
Main Affiliation
Email
ana.dm@medf.ukim.edu.mk
40 results
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Item type:Publication, Distribution of HPV types among patients with positive histological findings for cervical precancerous lesions and invasive cancer of the uterine cervix(Македонско лекарско друштво = Macedonian Medical Association, 2018); ; Introduction. The aim of this study was to provide basic data on the prevalence of different HPV types among the female population in R. Macedonia with histologically proven cervical intraepithelial neoplasia or invasive cervical cancer, in order to better plan the vaccination program and screening for cervical cancer. Mеthods. This study retrospectively statistically (using Statistica SPSS for Windows) analyzed histological findings positive for cervical intraepithelial neoplasia or invasive cervical cancer and positive HPV genoty- ping results of564 patients who came to the University Clinic for Gynecology and Obstetrics due to an abnor- mal Pap smear test during the last year (2017). Results. HPV isolation showed the presence of human papillomavirus in78% of the total of 564 subjects. The prevalence of HPV in LSIL, HSIL, invasive squamo- cellular carcinoma of the uterine cervix and adeno- carcinoma of the uterine cervix was 69.2%, 87.2%, 97.6% and 71.4%, respectively. HR HPV types were isolated in 75%of LSIL and 96% of HSIL. Predo- minantly isolated were HPV types 16, 18, 35, 31, 33, 58, 6, 11 and 40. HPV type 16 wasthe most commonisolated genotype among all patients with 48.4%, 30.1% and 19.6% in HSIL, invasive carcinoma and LSIL, respect- tively. HPV type 18 had the highest rate in patients with invasive adenocarcinoma of the cervix (30.1%). Conclusion. Human papillomavirus types 16, 18, 35, 31, 33, 58, 6, 11 and 40were the predominant high risk types in patients with invasive cervical cancer and its precursors in the Republic of Macedonia. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, SUCCESSFULLY DELAYED DELIVERY OF SECOND TWIN AFTER EARLY SECOND TRIMESTER RUPTURE OF MEMBRANES OF THE FIRST TWIN: A CASE REPORT(Институт за јавно здравје на Р Северна Македонија = Institute of Public Health of R North Macedonia, 2020-07); ; ; Twin pregnancies are high-risk pregnancies accompanied with multiple complications, such as: spontaneous abortion, preterm rupture of the membranes, preterm delivery, intrauterine death of one or both twins etc. There is no consensus about the management of twin pregnancies complicated with preterm rupture of the membranes of one twin and risk of preterm delivery. These cases are rarely found in the literature. We present a case of a 35 years old patient, hospitalized in a tertiary level institution, because of a diamniotic dichorionic twin pregnancy complicated with preterm rupture of the membranes of the first twin at 19 weeks of gestation. She had one delivery with Caesarean section 16 years ago. In consultation with the patient induction of labor was done with delivery of the first twin, a death male fetus. After that, antibiotics and tocolytic therapy were administrated and the patient remained in the hospital about one week. The patient was discharged at home with regular control of her condition and condition of the fetus. The patient was again hospitalized at 33 weeks of gestation with uterine contractions on cardiotocography. After administration of corticosteroid therapy for fetal lung maturation she delivered spontaneously the second twin in a good condition and she was discharged from hospital after 16 days. In twin pregnancies clinicians must think about delayed interval delivery of the second twin, after delivery of the first twin, with an aim to increase chances for survival, especially for pregnancies less than 30 weeks of gestation. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, MATERNAL OBESITY, АGE AND MATERNAL THYROID STATUS - AN INTRIGUING CONNECTION TO THE NEONATAL OUTCOME(Македонско лекарско друштво /Macedonian Medical Association, 2020); ; Introduction. Thyroid dysfunction is the second most common endocrine disorder affecting women of reproductive age. Higher body mass index (BMI>30 kg/m2) is linked with many endocrine abnormalities, including thyroid dysfunction. Gestational age at birth (GAB) and birth weight (BW) are important predictors of neonatal mortality and morbidity. The objective of this prospective study was to determine the adverse neonatal outcomes of women [small for gestational age (SGA), intrauterine growth restriction (IUGR) and others] complicated with impaired thyroid function and obesity, when compared with those with normal function. Methods. Dried blood spot and urine samples were analyzed for thyroid and iodine status in 358 pregnant women in any gestational week, without known thyroid disorders. They gave birth at the University Clinic of Gynecology and Obstetrics-Skopje. The blood samples were analyzed with time-resolved fluoroimmunoassay in Zurich, and UIC was analyzed by mass spectrometry in Helsinki. Results. We found a significant positive correlation between total thyroxine (TT4) and GAB (p=0.045) and UIE and mother age (p=0.007), but a significant negative correlation between GAB and UIE (p=0.051), GAB and mother’s age (p=0.01), GAB and BMI (p=0.02). There was an inverse correlation between BW and maternal age (βst=-0.0641, P=0.010) and between BW and maternal TT4 (βst=-3.3640, P=0.0016). We found a positive correlation between BW and maternal BMI (βst = 21.847, P = 0.006). Conclusion. Overweight, obese and older women are at increased risk of thyroid dysfunction during pregnancy considered as high-risk pregnancies for adverse neonatal outcomes. We can use maternal TT4, BMI and age for predicting the BW. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ПЕРИУРЕТЕРАЛНА ЕНДОМЕТРИОЗА – ПРИКАЗ НА СЛУЧАЈ(SHMSHM - AAMD, 2022-09-01); ; ; ; Целта на овој труд е да се прикаже редок случај на периуретерална ендометриоза кај возрасен пациент и да се нагласи важноста на сомнителната уринарна ендометриоза и важната улога на компјутер на мала карлица во поставувањето на точна дијагноза на оваа ретка болест. Презентираме редок случај на периуретерална ендометриоза со симптоми кои првенствено произлегуваат од ендометриоза на јајниците. Дијагнозата на периуретерална ендометриоза беше поставена врз основа на компјутеризирана томографија на малата карлица и абдоменот. Клучни зборови: ендометриоза, компјутер на мала карлица, периуретерална ендометриоза. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Subjective Quality of Life of Women in the Perinatal Period: A Post Covid-19 Pandemic Exploration in North Macedonia(Македонска академија на науките и уметностите, Одделение за медицински науки = Macedonian Academy of Sciences and Arts, Section of Medical Sciences/Walter de Gruyter GmbH, 2023-03-01); ; ; Subjective quality of life could be considered one of the indicators of health behavior and wellbeing of women in the perinatal period. Accordingly, the aim of this paper was to examine how women in perinatal period perceive quality of life in various domains. Its relationship to age, number of pregnancies, course of pregnancies, and method of delivery and experience with Covid-19 pandemic was investigated, as well. Our sample consisted of 366 pregnant women in any period of pregnancy who came in for regular outpatient examinations and control, those who were hospitalized due to pathological pregnancy or due to the need for intensive care, as well as women in their postnatal period, one year after delivery, who were seeking professional advice from a gynecologist. The majority were aged 20 to 30 years (53.8%). The findings showed that assessed domains of subjective quality of life were related to a variety of experiences with the Covid-19 pandemic. The results are presented and discussed in detail. Implications and limitations are given, as well. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, HYDROSALPINX AND DISTRIBUTION OF PREGNANCIES AMONG LAPAROSCOPICALLY TREATED PАTIENTS(Македонско лекарско друштво = Macedonian Medical Association, 2020); ; Introduction. Hydrosalpinx is a common medical condition encountered among female population with infertility issues. One or both fallopian tubes can be filled with a substantial amount of fluid, making them dilated and dysfunctional, usually as a result of an injury or infection. Damages of different degrees can be seen on the mucosal lining, which compromise the processes of normal fertilization and zygote passage. Methods. We retrospectively analyzed clinical records from a period of five years (2013-2017), selecting pa- tients diagnosed as having unilateral or bilateral hydrosalpinx. Clinical files were divided by years and according to the treatment protocol used. Our scope of interest was focused on patients who were treated surgically, with different types of laparoscopic interventions. A total of 74 patients met our criteria for selection. Results. Two groups were related to conservative la- paroscopic approaches and one to complete radical surgical treatment, unilateral or bilateral salpingectomy. Patients in the first group, 9(16.36%), were treated with a laparoscopically-guided creation of salpingostomy. The second group comprised patients treated only with bi- lateral chromopertubation and consisted of 17 (30.91%) patients. The third, and the most numerous group com- prised 29(52.7%) patients treated with salpingectomy. Bilateral salpingectomy was performed in 9(31.03%) and unilateral in 20(68.97%) patients, showing that majority of patients were treated with unilateral salpingectomy, after intraoperative evaluation of tubal patency of the contralateral uterine tube. A total number of 30 patients (54.5%) had successful pregnancies, which ended up with a desired outcome, healthy live birth. Procedures for artificial reproduction and successful pregnancies achieved with IVF were recorded in 11(36.67%) patients and in the remaining 19(63.33%) patients pregnancies were achieved via spontaneous conception. Conclusion. Hydrosalpinx management is mainly influenced by the local tubal changes evaluated laparoscopically and can be surgically treated, either conservative or radical. Conservative approaches lead to fair chances of spontaneous conception and successful pregnancies. An integrated management of hydrosalpinx with bilateral salpingectomy and postsurgical usage of artificial reproduction techniques also leads to a substantial cumulative pregnancy rate. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The outcome of Pregnancy with Fetal Primitive Neuroectodermal Tumor(ID Design 2012/DOOEL Skopje, 2018-08-20); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ISOLATED MATERNAL HYPOTHYROXINEMIA AND ITS PERINATAL OUTCOME IN NORTH MACEDONIA(Sestre Milosrdnice University Hospital Center (KBC Sestre milosrdnice), 2021-06); ; Isolated maternal hypothyroxinemia (IMH) is defined as the presence of low maternal total thyroxine (TT4) level in conjunction with normal maternal thyroid-stimulating hormone (TSH) level. The aim was to investigate whether IMH is associated with adverse pregnancy outcome in North Macedonia. Dried blood spot samples were obtained from 359 pregnant women meeting the inclusion criteria and analyzed for TT4 and TSH. Postpartum data were entered from their medical histories. Out of 359 women, 131 (37.42%) belonged to IMH group. There were statistically significant differences in birth weight (p=0.043), intrauterine growth restriction (IUGR) (p=0.028), Apgar score at 1 min <7 (p=0.018) and cesarean section for dystocia/disproportion (p=0.024) between the IMH and normal thyroid function (NTF) groups. In regression analysis, TSH was a significant variable predicting Apgar score (βst=0.05597, p=0.047), body mass index predicting birth weight (βst=0.02338, p=0.045) and TT4 predicting small for gestational age/IUGR (βst=-0.089834, p=0.029) in IMH group. TT4 was a strong predictor of birth weight (βst=-0.004778, p=0.003) and premature delivery (βst=0.028112, p=0.004) in NTF group. The impact of IMH in pregnancy remains controversial. IMH was associated with an increased maternal BMI and higher birth weight of neonates. Overweight could be a potential risk factor for thyroid dysfunction in pregnant women, and specifically IMH. The worst fetal outcome was seen in IMH mothers examined in second trimester. We found TSH, TT4 and BMI to be strong predictors of perinatal outcomes. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Thyroid Function of Pregnant Women and Perinatal Outcomes in North Macedonia(Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, 2021-10) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Echocardiographic Heart Changes in Pregnancies Complicated with Gestation Hypertension and Preeclampsia(International Scientific Invention Journals, 2019-02-13); ; ; Introduction: Echocardiography as an imaging method is increasingly being used in obstetrics in the management of hemodynamic changes which occur in normal but also in pregnancies with gestational hypertension/preeclampsia. Aim: The aim of the study is to show that some of the heart changes in pregnancies complicated with gestational hypertension and preeclampsia are abnormal and further follow up of these patients is needed. Methods: A total of 81 patients were enrolled in the study. The patients were further divided in two groups. Pregnant women with gestational hypertension or preeclampsia (51) and a control group of normotensive pregnancies (30). A total of 3 echocardiograph exam were made, the first upon entry in the study (28 -34 g.w), the second 2 weeks after delivery and the last 6 months after delivery. Results and discussion: We found several statistically significant results that involve the IVS, PWLV, LKM, left chamber hypertrophy and diastolic function. Diastolic dysfunction usually shows up before systolic dysfunction in the evolution of ischemic/hypertensive cardiovascular disease and is of prognostic value in predicting long term cardiovascular morbidity. The changes seen 6 months after delivery on our last control mean that those changes are permanent and need further prevention strategies. Conclusion: From the noninvasive methods echocardiography is the most favorable method in identifying structural changes and functional changes in pregnancies with hypertension. Echocardiography allows fast, reproducible information and is both safe for mother and fetus.