Tripunoski, Toni

Preferred name

Tripunoski, Toni

Official Name

Tripunoski, Toni

Main Affiliation

t.tripunoski@medf.ukim.edu.mk

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Few case studies as ideas for zero-waste from food production and processing
(University of Sarajevo, Institute for Genetic Engineering and Biotechnology, 2023-12-20)
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Svetozarevic Arsovic, Milica
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Saiti Musliji, Zimere
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Chadikovski, Aleksandar
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Abazi Bajrami, Drita
Globally, the amount of agricultural waste is huge but not properly utilized yet. Precisely, about one billion tons of food produced for human consumption is wasted each year. This wastage global economy costs are estimated at US$ 1 trillion on annual level. The definition of food waste varies globally depending on where food waste occurs in the food supply and consumption chain, how it is generated, and what it covers. This review is a compilation of few different approaches in the context of zero waste from food production and processing. Soybean hull exploitation due to mass production of tofu, soymilk, edamame, tofu sausages and burgers, soy breads, soy pasta and soymilk yoghurts and cheeses, animal feed leads to a formation of high waste load. There are several available ways for soybean hull valorization: as a biofertilizer, as a substrate for microbial growth, as an adsorbent, for extraction of antioxidants and in our case for extraction of enzymes. The global consumption of coffee is approximately 10 million tons, resulting in a substantial production of spent coffee grounds (SCG) worldwide. However, this by-product has recently gained attention as a valuable source of usable compounds, particularly in our case for essential oils. During the cheese production process, the whey obtained as a by-product can be used as a raw material for development of new dairy products and in the same time to prevent the potential pollution of natural watercourses. The valorisation of the waste whey obtained in the cheese production by using it in the development of new products also contributes in the environment protection. In N. Macedonia, about 1000 tons of blood waste from industrial slaughterhouses flow into natural watercourses every year and it can find application in various industries. These are just a few examples that show that the possibilities for the implementation of the zero-waste concept are unlimited.
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Insulin, insulin resistance and antropometric parameters in overweight and obese women
(Macedonian Association of Anatomists and Morphologists, 2013)
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Lower limb perfusion scintigraphy with 99mTc-MIBI scintigraphy and determination of endothelin in diabetic and nondiabetic patients
(National Library of Serbia, 2020)
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Pop Gjorceva, Daniela
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Relationship of circulating adiponectin levels to subcutaneous and visceral fat tissue in overweight obese women
(Macedonian association of physiologists and anthropologists, 2012)
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ADRENAL GLAND TLR EXPRESSION IN ApoE DEFICIENT HOMOZYGOUS (ApoE KO-/-) MICE WITH IMPAIRED THYROID FUNCTION
(Macedonian Association of Anatomists and Morphologists, 2023-12)
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Josifovska, Slavica
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The main aim of our study was to investigate the expression of TLR receptors in the adrenal gland of ApoE knockout mice in context of ApoE deficiency as well as impaired thyroid function (hypo- and hyperthyroidism). The study was conducted on two following experimental animal groups: hypothyroid homozygous mice (ApoE KO-/-) treated with PTU; hyperthyroid homozygous mice (ApoE KO-/-) treated with L-thyroxine (T4) and two control groups: euthyroid homozygous mice (ApoE KO-/-) and euthyroid wild-type C57BL/6 mice (Bb). Determination of TLR gene expression in the adrenal gland was performed by RT-PCR reaction with semi-quantitative detection of populations of mRNA molecules transcribed from the TLR2, TLR4 and TLR9 genes in the adrenal gland in the treated experimental groups and the two untreated control groups. The results of our study are in support of the hypothesis that both conditions of impaired thyroid function produce TLR agonists that increase the expression of TLR in the adrenal gland (p<0,05). Also, in the untreated/control group of mice (ApoE KO-/-), an increased expression of TLR was found compared to the wild strain C57BL/6 mice (Bb) as a control group (p<0.001).
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APPLICATION OF THE SINGLE CELL GEL ELECTROPHORESIS FOR DETECTION OF OXIDATIVE DNA DAMAGE DUE TO LONG TERM EXPOSURE TO SUPRAPHYSIOLOGIC DOSES OF L-THYROXINE
(Macedonian Association of Anatomists and Morphologists, 2018)
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Atanasovska M
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Bundovski K
Since reactive oxygen species (ROS) induced by thyroid hormones may cause lipid and protein oxidation as well as DNA damage, the main aim of this article is to investigate the genotoxic effect (in vivo) of the supraphysiologic doses of L-thyroxinein apolipoprotein E deficient homozygous (ApoE-/-) mice. For this purpose, the method of single-cell gel electrophoresis that allows the detection of DNA damage in individual cell caused by various endogenous and exogenous agents was used. The Student t-test has shown no significant difference between the examined parameters of the thyroxine-treated group compared with untreated control group of animals. The positive control (treated with solution of H2O2) has significantly higher values of the examined parameters compared with the treated and untreated control group of animals. The results confirm that chronic exposure to high doses of thyroxine do not cause damage to the DNA molecule that could be detected by the method of single-cell gel electrophoresis.
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Sarcoidosis of the Thyroid Gland and Concomitant Hürthle Cell Adenoma: Case Report
(Centre for Evaluation in Education and Science (CEON/CEES), 2009-04-01)
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Todor Gruev
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Svetlana Ristevska
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Sarcoidosis of the Thyroid Gland and Concomitant Hürthle Cell Adenoma: Case Report Sarcoidosis is a multisystem disorder, characterized by the presence of noncaseating epithelioid-cell granulomas. The etiology remains unclear, although it is recognized as a disease of activated T lymphocytes. There is a diverse range of possible presentations with respiratory, gastrointestinal, reproductive, endocrine and other complications. The thyroid is an uncommon site of the disease with only 4% incidence according to some autopsy series. We present a case of a 55-year-old female patient with sarcoidosis of the thyroid gland and concomitant Hürthle cell adenoma. Upon performing a routine thyroid scintigraphy, a cold nodule has been observed. The diagnosis of the underlying disease was established by correlating the anamnesis data, patient's clinical history, fine needle aspiration biopsy and pathological examination of the thyroidectomy specimen. To our knowledge, the association has rarely been previously reported, indicating that thyroid involvement should be suspected in sarcoidosis patients who present with cold nodules.
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Determining thyrotropin and thyroglobulin transcripts in peripheral blood of thyroid carcinoma patients and healthy individuals
(Springer, 2018-09-18)
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EXPERIMENTAL ANIMAL MODEL OF THYROID DYSFYNCTION- HYPERTHYROIDISM
(Macedonian Association of Anatomists and Morphologists, 2023-12)
Stojkovska, Natasha
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Tasheva, Ljubica
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To establish an experimental animal model of impaired function of the thyroid gland – hyperthyroidism. Thyroid dysfunction (hypothyroidism, hyperthyroidism) is classified in the group of non-communicable diseases with high incidence and prevalence. The disturbed function of the thyroid gland reflects in the metabolic processes of organs, tissues and at cellular level. Twenty Wistar rats (10 males - 350 ± 40 gr and 10 females - 320 ± 40 gr), with an average age of 7 months, were analyzed in the period of 2 months (treated for 1 month with pharmacological doses of L-Thyroxin 15mg / 100g body mass in the drinking water and 1 following month without treatment). The second group of 10 Wistar rats - (5 males and 5 females) did not recieve L-Thyroxin and this was the control group used to obtain normal morphometric and biochemical parameters. Between the mean values of FT4 and FT3 at the beginning, at the intersection and at the end of the study, there were statistically significant differences with increased levels of thyroid hormones at the cross section and no statistically significant difference of thyroid hormone levels between the beginning and the end of the examination in the group of rats treated with L-Thyroxin. No statistically significant differences were detected in the control group of rats. Experimental animal model of impaired function of the thyroid gland – hyperthyroidism using Wistar rats as subjects was successfully established.
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Determining Specific Thyroid Transcripts in Peripheral Blood: A Single Center Study Experience
(Walter de Gruyter GmbH, 2018-12)
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Thyroid carcinoma (TC) comprises a spectrum of different tumors with a wide range of biological behavior and prognosis. The techniques based on the latest trends in molecular biology may have application in diagnosis of metastatic TC. The aim of this study was to apply and analyze mRNA expression in peripheral blood of thyrotropin receptor [thyroid stimulating hormone receptor (TSHR-mRNA)] gene and thyroglobulin (Tg-mRNA) gene using 2-ΔΔCt method in differentiated TC patients and healthy individuals. Fifty-seven subjects were included in the study, consisting of 40 patients with TC and 17 healthy volunteers as a control group. Total RNA was isolated from peripheral blood and used for two-step reverse transcriptase-polymerase chain reaction (PCR). Real-time PCR was performed with appropriate primers. Relative quantification using the 2-ΔΔCt method was applied. Thyroid carcinoma patients with metastatic disease or loco-regional relapse expressed TSHR-mRNA by a 8.57-fold higher level than healthy controls. Thyroid carcinoma patients with biochemical relapse expressed TSHR-mRNA by a 14.17-fold higher level than healthy controls, while expression of Tg-mRNA was 6.6-fold higher in TC patients with metastatic disease and loco-regional relapse than healthy controls and 8.34-fold higher level compared with TC patients with excellent response to treatment. Our preliminary study showed that the TSHR gene expression might have more useful application as a biomarker compared to detection of Tg gene expression.

Tripunoski, Toni

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