Panov, Sasho
Preferred name
Panov, Sasho
Official Name
Panov, Sasho
Main Affiliation
Email
sasho@mt.net.mk
31 results
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Item type:Publication, Molecular Biology and Genetic Mechanisms in the Progression of Malignant Skin Melanoma(Macedonian Academy of Sciences and Arts / Sciendo, 2016-11); ; ; Malignant skin melanoma is a tumor deriving from transformed skin melanocytes as a result of complex interactions between genetic and environmental factors. This melanoma has a potential to metastasize early and very often it is resistant to the existing modalities of the systemic therapy. As in any other neoplasms, certain types of melanoma may skip certain stages of progression. The progression from one stage to another is accompanied by specific biological changes. Several key changes in the melanoma tumorogenesis influence the regulation of the cell proliferation and vitality, including the RAS-RAF-ERK, PI3K-AKT, and p16INK4/CDK4/RB pathways. A key role in the dissreguarity of the RAS-RAF-ERK (MAPK) pathway in the malignant melanoma development have been demonstrated by many studies. To date, the molecular genetic alterations during melanoma development have been partially known. In the pathogenesis of the malignant melanoma, there are mutations of various genes such as NRAS, BRAF, and PTEN and mutations and deletions of CDKN2A. In the past years, great advance has been made in the insights of the molecular aspects of the melanoma pathogenesis. However, this field yet poses a challenge to discover new details about the melanoma molecular characteristics. The research results are focused towards the improvement of the melanoma patients prognosis by introducing personalized targeted therapy. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ADRENAL GLAND TLR EXPRESSION IN ApoE DEFICIENT HOMOZYGOUS (ApoE KO-/-) MICE WITH IMPAIRED THYROID FUNCTION(Macedonian Association of Anatomists and Morphologists, 2023-12); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, APPLICATION OF THE SINGLE CELL GEL ELECTROPHORESIS FOR DETECTION OF OXIDATIVE DNA DAMAGE DUE TO LONG TERM EXPOSURE TO SUPRAPHYSIOLOGIC DOSES OF L-THYROXINE(Macedonian Association of Anatomists and Morphologists, 2018); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Double heterozygosity of novel variants found in patients with severe clinical phenotype of cardiovascular disorders(Informa UK Limited, 2018-02-06); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Clinical genetic study in juvenile myoclonic epilepsy(2014-11); ; To evaluate clinical features of probands with juvenile myoclonic epilepsy (JME) and affected members of their families in order to study clinical genetics of JME. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Association of mutation in BRAF gene (V600E) with the clinical progression of disease in patients with metastatic skin melanoma(SHMSHM / AAMD, 2017); ; Malignant melanoma is the most aggressive form of skin neoplasm characterized by very rapid clinical progression and high mortality. Current studies indicates that progression, treatment response and prognosis of metastatic melanoma depends on the molecular-genetic abnormalities and their specific combinations in malignant melanocytes. In malignant melanoma, somatic mutations in BRAF gene are most frequent at nucleotide position 1799, where most common transition substitution T>A results in valine being substituted with glutamine (p.Val600Glu or abbreviated as V600E) at amino acid position 600 of the B-Raf protein product. BRAF V600E mutation has been found frequently in patients with metastatic melanoma of the skin.The main goal of this study is to determine the correlation of BRAF V600E mutation presence with the survival of patients with metastatic melanoma of the skin.In the preliminary phase of this observational prospective study, the presence of BRAF V600E mutation was determined in 16 patients with histopathologically confirmed metastatic melanoma of the skin.The results of the analyses performed thus far indicates the presence of correlation of BRAF V600E mutation with the clinical progression of the disease, particularly with the survival during the 12-months evaluation period in patients with metastatic melanoma of the skin. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Hyperhomocysteinemia and the Methylenetetrahydrofolate Reductase (C677T) Genetic Polymorphism in Patients with Deep Vein Thrombosis(ScopeMed Publishing, 2013); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Does the Apolipoprotein E Genotype Increased the Risk of Postoperative Delirium in Adult Patients?(Department of Anaesthesia and Reanimation, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, R.N. Macedonia, 2023-12); ; ; ; Toleska, MarijaBackground: The relationship between genetic predisposition and the development of postoperative delirium has not yet been established. The e4 allele of the apolipoprotein E gene has been reported as a genetic risk factor for delirium. Objective: This paper analyzed the relationship between the frequency of genotypes of the APOE rs7412/rs429358 polymorphism, which contains the minor allele e4, and the occurrence of postoperative delirium. Material and Methods: The study included patients aged 65 years and older without pre-existing cognitive impairment admitted to the University Clinic for Traumatology and Orthopedics for operative treatment of a fracture of the upper end of the thighbone. The Confusion Assessment Method (CAM) confirmed the delirium diagnosis. APOE rs7412/rs429358 polymorphism genotypes were determined by molecular genetic analysis using the quantitative real-time amplification method (qRT-PCR) on DNA samples extracted from venous blood leukocytes. Results: The presented results are from analyzed samples and data from 51 patients. Out of these, postoperative delirium was diagnosed in 12 patients, while in 39 patients weren’t registered, and they are the control group in the trial. Conclusion: This study results indicate the association of the studied polymorphism in the apolipoprotein E gene, which contains the minor allele e4, with the occurrence of postoperative delirium in this group of adult patients. A larger group is necessary to reach more valid conclusions. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Regulation of carbohydrate metabolism and insulin secretion in diabetic rats following treatment with Hypericum perforatum L. hairy root aqueous methanol extract(Society of Chemists and Technologists of Macedonia, 2024-05-19); Petreska Stanoeva, JasminaHairy root (HR) cultures of Hypericum perforatum L. have shown promise in controlling hyperglycemia, regulating blood lipid and enzyme profiles, and improving metabolic function in vivo. These benefits are mainly attributed to the phenolic acids, flavonoids, and xanthones present in HR extracts. However, the specific mechanism underlying these effects remains unclear. This study was performed to elucidate the biochemical and molecular mechanisms driving HR the antihyperglycemic and antidiabetic effects of HR extracts. HR extract (200 mg/kg body weight) was administered daily for 14 days to healthy rats and rats with streptozotocin-induced diabetes, with glibenclamide serving as a positive control. The phenolic composition of the HR extracts was confirmed through high-performance liquid chromatography/diode array detection/electrospray ionization mass spectrometry (HPLC/DAD/ESI-MSn ) analysis. The results showed that HR extract treatment increased the plasma insulin level and pancreatic poly (adenosine diphosphate-ribose) polymerase (PARP) activity in diabetic rats, thus normalizing blood glucose levels. Additionally, it reduced the activity of gluconeogenic enzymes, increased the activity of glycolytic enzymes, and normalized the glycogen content in the liver. HR extract-treated rats also exhibited increased hepatic adenosine monophosphate-activated protein kinase (AMPK) mRNA expression and a decreased protein kinase Cε (PKCε) concentration. In conclusion, HR extract demonstrated insulinotropic effects and effectively regulated hepatic carbohydrate metabolism in diabetic rats by modulating AMPK expression and the PKCε concentration. These findings suggest the potential use of HR extract as an herbal medicine for diabetes treatment and a source of antidiabetic drug development.