Komina, Selim
Preferred name
Komina, Selim
Official Name
Komina, Selim
Main Affiliation
Email
selim.komina@medf.ukim.edu.mk
34 results
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Item type:Publication, The outcome of Pregnancy with Fetal Primitive Neuroectodermal Tumor(ID Design 2012/DOOEL Skopje, 2018-08-20); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Incidence of Urinary Tract Tumours in a Two-Year Period (2010-2011) at the Institute of Pathology, Faculty of Medicine, Skopje, Macedonia(Walter de Gruyter GmbH / MANU, 2014); ; ; ; Bodganovska-Todorovska, MagdalenaWe performed a retrospective analysis of tumours of the kidneys and the lower urinary tract diagnosed at the Institute of Pathology, Faculty of Medicine, Ss. Cyril and Methodius University, Skopje, Macedonia, in a two-year period (2010-2011), with the aim of highlighting the main morphological characteristics and to present the statistical features of these tumours. All the cases were diagnosed on paraffin sections from surgical specimens routinely stained with H&E, and immunohistochemically with a panel of monoclonal antibodies. The analysis revealed a total of 755 cases, of which 166 (14%) were located in the kidney including the renal pelvis, and 649 (86%) were tumours of the urinary bladder. Twelve of the renal tumours (11.3%) were benign, and the rest were malignant tumours. Most of them were adenocarcinomas (n=77; 72.6%) and 17 cases (16%) were transitional cell carcinomas originating from the renal pelvis. The analysis of the lower urinary tract tumours showed a strong prevalence of malignant urothelial tumours (96%), with a male to female ratio of almost 4:1. Low grade morphology was a predominant feature (71.7%) and 51 cases (22.9%) were of high grade. The percentage of urothelial tumours of the kidney in our series is higher than in most of the reported series, which should lead to an expanded analysis. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Solitary metastatic deposit in the mandible from follicular thyroid carcinoma(2020-07-01); ; ; ; Follicular thyroid carcinoma (FTC) is the second most common cancer of the thyroid, after papillary carcinoma. Oral metastasis arising from FTC is very rare. Mandible is more commonly affected than maxilla, with the premolar-molar region being the most frequent site of metastasis. We present the case of a 68yearold female, with swelling in the region of the parotid gland, complaining of periodic rightsided pain in the temporomandibular joint, which occurred most often in the morning with numbness and pain, and difficulty in opening the mouth. After ultrasound and X-ray, the patient was operated and the pathohistological finding was in favor of metastasis of FTC. After 3 months, a total thyroidectomy was performed, and FTC was detected in the right thyroid lobe. Laboratory results were as follows: FT4 = 9.92 pmol/L, thyroid-stimulating hormone = 9.9 mIU/L, and hTG >300 μg/L. Bone scan showed no bone metastasis. Radioablation with 131I of 150 mCi was given to the patient, followed by substitutional therapy with levothyroxine. Mandible metastasis as a single skeletal deposit from follicular thyroid carcinomas is a rare clinical finding. Maxillofacial surgeons should consider and rule out thyroid pathology before performing operation of tumor formation in the mandible region. If feasible, surgical-based treatment options offer the best survival outcomes. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, PRIMARY SINONASAL MENINGIOMA MIMICKING BENIGN NASAL LESIONS - A CASE REPORT AND LITERATURE REVIEW(Macedonian Association of Pathology and North Macedonia Division of IAP, 2025); ; ; Jovcheva, AIntroduction: Primary extracranial meningiomas are rare neoplasms, accounting for less than 2% of all meningiomas. The sinonasal tract represents an uncommon site of origin and frequently presents diagnostic challenges due to nonspecific clinical and radiological features. Case Presentation: A 79-year-old male presented with a unilateral nasal cavity mass. Computed tomography revealed diffuse polypoid mucosal thickening with near-complete opacification of paranasal sinuses and obliteration of aeration. Histopathology showed a circumscribed neoplastic proliferation arranged in lobular and whorled patterns beneath intact respiratory epithelium. Tumor cells displayed uniform morphology with oval nuclei, eosinophilic cytoplasm, and inconspicuous nucleoli. Psammoma bodies and delicate vascular channels were present. Necrosis, nuclear atypia, and mitotic activity were absent. Immunohistochemistry showed strong positivity for epithelial membrane antigen (EMA), vimentin, p63, and progesterone receptor, while cytokeratin AE1/AE3, CD34, smooth muscle actin (SMA), S100, SOX10, desmin, and synaptophysin were negative. The proliferative index (Ki-67) was <5%. Discussion: Extracranial meningiomas are rare neoplasms with poorly understood histogenesis, presumably arising from displaced meningothelial cells during embryonic development. Sinonasal meningiomas may mimic other nasal masses including nasal polyps, inverted papilloma, olfactory neuroblastoma, or carcinoma. In this case, the morphological features combined with the supportive immunohistochemical profile confirmed the diagnosis of WHO Grade I meningothelial meningioma with angiomatous features. Conclusion: Primary sinonasal meningioma should be included in the differential diagnosis of sinonasal masses. Accurate recognition through comprehensive histopathological and immunohistochemical analysis is essential for proper diagnosis and management. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, SQUAMOUS CELL CARCINOMA ARISING IN A KELOID SCAR: A CASE REPORT AND LITERATURE REVIEW(Macedonian Association of Pathology and North Macedonia Division of IAP, 2025); ; ; Angelovska TIntroduction: Keloids are characterized by abnormal fibroblast proliferation and excessive collagen deposition. While typically benign, they have been recognized as potential predisposing factors for cutaneous neoplasia. Case Presentation: We present a rare case of squamous cell carcinoma (SCC) arising within a keloid scar in a 38-year-old female with a history of exuberant keloid formation on the feet. Histopathological examination of the excised lesion revealed moderately differentiated SCC developing within keloid tissue, marked by invasive nests of atypical squamous cells and keratin pearl formation embedded in dense keloidal stroma. Conclusion: Although exceedingly rare, malignant transformation of keloid scars into SCC can occur, particularly in lesions exposed to chronic irritation, inflammation, ulceration, repeated trauma, or ultraviolet radiation. Clinicians should maintain a high index of suspicion when evaluating morphological changes in long-standing keloids. Early biopsy of suspicious lesions is crucial for timely diagnosis and appropriate management. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Incidental prostate cancer in patients undergoing radical cystoprostatectomy in treatment for bladder cancer: our five-year results(SHMSHM - AAMD, 2013); ; ; The aim of the paper was to verify the incidence and features of incidental prostate cancer in patients who underwent radical cystoprostatectomy for invasive bladder cancer. Methods and results: A total of 96 patients underwent radical cystoprostatectomy between January 2006 and December 2010 in the University Clinic of Urology in Skopje. 10 patients were excluded for incomplete data. The average age of the study group was 61.2 years (range 32-78). Prostate cancer was found in 10 (11.6%) cases. Seven patients were clinically insignificant. Conclusion: Incidentally diagnosed prostate cancer was frequently insignificant. Digital rectal examination and prostate specific antigen should be part of the diagnostic procedure in patients who undergo cystoprostatectomy. Standard RCP which include removal of bladder with prostate gland and seminal vesicles is safer for radicality and prevention of residual prostate cancer. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Pregnancy with fetal brain tumor(Македонско лекарско друштво = Macedonian medical association, 2024-04-25); ; ; Josheva, JasminkaFetal intracranial tumors are exceptionally rare, occurring at an overall incidence of 0.34 per one thousand live births. As per the 2016 classification of central nervous system tumors, primitive neuroectodermal tumors (PNETs) are categorized as highly malignant embryonal tumors in WHO Group IV. This case involves a 29-year-old in her third pregnancy, with two previous uneventful term deliveries. At 27+3 gestational weeks, she sought care at the University clinic due to fetal hydrocephalus. An ultrasound at 28 gestational weeks revealed a heterogenous, tumor-like mass measuring 70x66mm in the right brain hemisphere. The fetal head exhibited a whole dilated right ventricle (26mm posterior horn dimension) with a leftward shift of the cerebral falx. Subsequent fetal MRI demonstrated a partly solid, partly cystic tumor with a heterogenous appearance in T2 pulse sequence, extending in a frontoparietal direction. The differential diagnosis included glioblastoma. Following comprehensive scans, the parents were informed of the potential outcomes. The newborn, unfortunately, did not survive, weighing 1700g and measuring 42 centimeters. Pathological evaluation identified a primitive neuroectodermal tumor in the right parietal lobe, accompanied by internal hydrocephalus and cerebral encephalomalacia. Microscopic examination showcased Homer-Wright rosette formations, consisting of moderately differentiated round to oval cells with eosinophilic to amphophilic cytoplasm and hyperchromatic nuclei surrounding a central core of neurofibrillary material. Immune histochemical staining confirmed the tumor's profile, including Vimentin(+), S100(+), GFAP(+), Actin(-/+), Desmin(-), CD99(-), EMA(-), CKWS(-), Chromogranin(-), NSE(+), WT1(+), and Synaptophysin positivity in single cells with dendrites. The proliferative index stood at 2-3%. In summary, this rare case emphasizes the challenges of antenatal PNET diagnosis, with only 18% identified before or at delivery among tumors presenting in the first year of life. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Effect of bladder cancer variant histology on survival outcome in patients treated with radical cystectomy: A single-centre experience(Wolters Kluwer - Medknow, 2021-07); ; ; ; Context: Bladder cancer (BC) is the sixth most common malignant neoplasm in men. Recently, great effort has been devoted to the study of BC variant histology (VH). Yet, the results from these studies have shown conflicting data and remain unclear whether their presence alters recurrence and survival rates after radical cystectomy (RC). Aims: We undertook this study aiming to test the effect on VH on recurrence-free survival (RFS) and overall survival (OS) in single-center RC patients. Settings and Design: We have retrospectively analyzed medical records and pathology reports from 331 patients who underwent RC with or without pelvic lymphadenectomy at University Urology Clinic-Skopje, North Macedonia, in the period between 2010 and 2018. Subjects and Methods: Microscopic analysis of the specimens involved the evaluation of histological tumor type, tumor grade, pathological tumor node metastasis stage, presence of lymphovascular invasion, and resection margin status. Statistical Analysis Used: Univariable and multivariable Cox regression models were applied to test the effect of VH on RFS and OS. Results: We found 185 patients who matched our inclusion criteria. At multivariable analyses, lymphovascular invasion and positive resection margins were associated with shorter RFS. Similarly, patients diagnosed with lymphovascular invasion, positive resection margins, and a pelvic lymph node metastasis had poorer OS. VH was not found to be an independent predictor of both RFS and OS (P > 0.05). Conclusions: The present study did not reveal prognostic effect of VH on RFS and OS. In our series, histomorphologic parameters including lymphovascular invasion, resection margins, and pelvic lymph node metastasis were the most relevant predictors on survival outcome after RC. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Cystis paratubaris mesonephricus lateris sinistri; their incidence, diagnostic challenge and treatment(SHMSHM - AAMD, 2020-04); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Comparative Proteomics Analysis of Urine Reveals Down-Regulation of Acute Phase Response Signaling and LXR/RXR Activation Pathways in Prostate Cancer(MDPI AG, 2017-12-29); Detecting prostate cancer (PCa) using non-invasive diagnostic markers still remains a challenge. The aim of this study was the identification of urine proteins that are sufficiently sensitive and specific to detect PCa in the early stages. Comparative proteomics profiling of urine from patients with PCa, benign prostate hyperplasia, bladder cancer, and renal cancer, coupled with bioinformatics analysis, were performed. Statistically significant difference in abundance showed 20 and 85 proteins in the 2-D DIGE/MS and label-free LC-MS/MS experiments, respectively. In silico analysis indicated activation, binding, and cell movement of subset of immune cells as the top affected cellular functions in PCa, together with the down-regulation of Acute Phase Response Signaling and Liver X Receptor/ Retinoid X Receptor (LXR/RXR) activation pathways. The most promising biomarkers were 35, altered in PCa when compared to more than one group. Half of these have confirmed localization in normal or PCa tissues. Twenty proteins (CD14, AHSG, ENO1, ANXA1, CLU, COL6A1, C3, FGA, FGG, HPX, PTGDS, S100A9, LMAN2, ITIH4, ACTA2, GRN, HBB, PEBP1, CTSB, SPP1) are oncogenes, tumor suppressors, and multifunctional proteins with highly confirmed involvement in PCa, while 9 (AZU1, IGHG1, RNASE2, PZP, REG1A, AMY1A, AMY2A, ACTG2, COL18A1) have been associated with different cancers, but not with PCa so far, and may represent novel findings. LC-MS/MS data are available via ProteomeXchange with identifier PXD008407.