Komina, Selim
Preferred name
Komina, Selim
Official Name
Komina, Selim
Main Affiliation
Email
selim.komina@medf.ukim.edu.mk
34 results
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Item type:Publication, Incidence of Urinary Tract Tumours in a Two-Year Period (2010-2011) at the Institute of Pathology, Faculty of Medicine, Skopje, Macedonia(Walter de Gruyter GmbH / MANU, 2014); ; ; ; Bodganovska-Todorovska, MagdalenaWe performed a retrospective analysis of tumours of the kidneys and the lower urinary tract diagnosed at the Institute of Pathology, Faculty of Medicine, Ss. Cyril and Methodius University, Skopje, Macedonia, in a two-year period (2010-2011), with the aim of highlighting the main morphological characteristics and to present the statistical features of these tumours. All the cases were diagnosed on paraffin sections from surgical specimens routinely stained with H&E, and immunohistochemically with a panel of monoclonal antibodies. The analysis revealed a total of 755 cases, of which 166 (14%) were located in the kidney including the renal pelvis, and 649 (86%) were tumours of the urinary bladder. Twelve of the renal tumours (11.3%) were benign, and the rest were malignant tumours. Most of them were adenocarcinomas (n=77; 72.6%) and 17 cases (16%) were transitional cell carcinomas originating from the renal pelvis. The analysis of the lower urinary tract tumours showed a strong prevalence of malignant urothelial tumours (96%), with a male to female ratio of almost 4:1. Low grade morphology was a predominant feature (71.7%) and 51 cases (22.9%) were of high grade. The percentage of urothelial tumours of the kidney in our series is higher than in most of the reported series, which should lead to an expanded analysis. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Solitary metastatic deposit in the mandible from follicular thyroid carcinoma(2020-07-01); ; ; ; Follicular thyroid carcinoma (FTC) is the second most common cancer of the thyroid, after papillary carcinoma. Oral metastasis arising from FTC is very rare. Mandible is more commonly affected than maxilla, with the premolar-molar region being the most frequent site of metastasis. We present the case of a 68yearold female, with swelling in the region of the parotid gland, complaining of periodic rightsided pain in the temporomandibular joint, which occurred most often in the morning with numbness and pain, and difficulty in opening the mouth. After ultrasound and X-ray, the patient was operated and the pathohistological finding was in favor of metastasis of FTC. After 3 months, a total thyroidectomy was performed, and FTC was detected in the right thyroid lobe. Laboratory results were as follows: FT4 = 9.92 pmol/L, thyroid-stimulating hormone = 9.9 mIU/L, and hTG >300 μg/L. Bone scan showed no bone metastasis. Radioablation with 131I of 150 mCi was given to the patient, followed by substitutional therapy with levothyroxine. Mandible metastasis as a single skeletal deposit from follicular thyroid carcinomas is a rare clinical finding. Maxillofacial surgeons should consider and rule out thyroid pathology before performing operation of tumor formation in the mandible region. If feasible, surgical-based treatment options offer the best survival outcomes. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Incidental prostate cancer in patients undergoing radical cystoprostatectomy in treatment for bladder cancer: our five-year results(SHMSHM - AAMD, 2013); ; ; The aim of the paper was to verify the incidence and features of incidental prostate cancer in patients who underwent radical cystoprostatectomy for invasive bladder cancer. Methods and results: A total of 96 patients underwent radical cystoprostatectomy between January 2006 and December 2010 in the University Clinic of Urology in Skopje. 10 patients were excluded for incomplete data. The average age of the study group was 61.2 years (range 32-78). Prostate cancer was found in 10 (11.6%) cases. Seven patients were clinically insignificant. Conclusion: Incidentally diagnosed prostate cancer was frequently insignificant. Digital rectal examination and prostate specific antigen should be part of the diagnostic procedure in patients who undergo cystoprostatectomy. Standard RCP which include removal of bladder with prostate gland and seminal vesicles is safer for radicality and prevention of residual prostate cancer. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Pregnancy with fetal brain tumor(Македонско лекарско друштво = Macedonian medical association, 2024-04-25); ; ; Josheva, JasminkaFetal intracranial tumors are exceptionally rare, occurring at an overall incidence of 0.34 per one thousand live births. As per the 2016 classification of central nervous system tumors, primitive neuroectodermal tumors (PNETs) are categorized as highly malignant embryonal tumors in WHO Group IV. This case involves a 29-year-old in her third pregnancy, with two previous uneventful term deliveries. At 27+3 gestational weeks, she sought care at the University clinic due to fetal hydrocephalus. An ultrasound at 28 gestational weeks revealed a heterogenous, tumor-like mass measuring 70x66mm in the right brain hemisphere. The fetal head exhibited a whole dilated right ventricle (26mm posterior horn dimension) with a leftward shift of the cerebral falx. Subsequent fetal MRI demonstrated a partly solid, partly cystic tumor with a heterogenous appearance in T2 pulse sequence, extending in a frontoparietal direction. The differential diagnosis included glioblastoma. Following comprehensive scans, the parents were informed of the potential outcomes. The newborn, unfortunately, did not survive, weighing 1700g and measuring 42 centimeters. Pathological evaluation identified a primitive neuroectodermal tumor in the right parietal lobe, accompanied by internal hydrocephalus and cerebral encephalomalacia. Microscopic examination showcased Homer-Wright rosette formations, consisting of moderately differentiated round to oval cells with eosinophilic to amphophilic cytoplasm and hyperchromatic nuclei surrounding a central core of neurofibrillary material. Immune histochemical staining confirmed the tumor's profile, including Vimentin(+), S100(+), GFAP(+), Actin(-/+), Desmin(-), CD99(-), EMA(-), CKWS(-), Chromogranin(-), NSE(+), WT1(+), and Synaptophysin positivity in single cells with dendrites. The proliferative index stood at 2-3%. In summary, this rare case emphasizes the challenges of antenatal PNET diagnosis, with only 18% identified before or at delivery among tumors presenting in the first year of life. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Effect of bladder cancer variant histology on survival outcome in patients treated with radical cystectomy: A single-centre experience(Wolters Kluwer - Medknow, 2021-07); ; ; ; Context: Bladder cancer (BC) is the sixth most common malignant neoplasm in men. Recently, great effort has been devoted to the study of BC variant histology (VH). Yet, the results from these studies have shown conflicting data and remain unclear whether their presence alters recurrence and survival rates after radical cystectomy (RC). Aims: We undertook this study aiming to test the effect on VH on recurrence-free survival (RFS) and overall survival (OS) in single-center RC patients. Settings and Design: We have retrospectively analyzed medical records and pathology reports from 331 patients who underwent RC with or without pelvic lymphadenectomy at University Urology Clinic-Skopje, North Macedonia, in the period between 2010 and 2018. Subjects and Methods: Microscopic analysis of the specimens involved the evaluation of histological tumor type, tumor grade, pathological tumor node metastasis stage, presence of lymphovascular invasion, and resection margin status. Statistical Analysis Used: Univariable and multivariable Cox regression models were applied to test the effect of VH on RFS and OS. Results: We found 185 patients who matched our inclusion criteria. At multivariable analyses, lymphovascular invasion and positive resection margins were associated with shorter RFS. Similarly, patients diagnosed with lymphovascular invasion, positive resection margins, and a pelvic lymph node metastasis had poorer OS. VH was not found to be an independent predictor of both RFS and OS (P > 0.05). Conclusions: The present study did not reveal prognostic effect of VH on RFS and OS. In our series, histomorphologic parameters including lymphovascular invasion, resection margins, and pelvic lymph node metastasis were the most relevant predictors on survival outcome after RC. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Comparative Proteomics Analysis of Urine Reveals Down-Regulation of Acute Phase Response Signaling and LXR/RXR Activation Pathways in Prostate Cancer(MDPI AG, 2017-12-29); Detecting prostate cancer (PCa) using non-invasive diagnostic markers still remains a challenge. The aim of this study was the identification of urine proteins that are sufficiently sensitive and specific to detect PCa in the early stages. Comparative proteomics profiling of urine from patients with PCa, benign prostate hyperplasia, bladder cancer, and renal cancer, coupled with bioinformatics analysis, were performed. Statistically significant difference in abundance showed 20 and 85 proteins in the 2-D DIGE/MS and label-free LC-MS/MS experiments, respectively. In silico analysis indicated activation, binding, and cell movement of subset of immune cells as the top affected cellular functions in PCa, together with the down-regulation of Acute Phase Response Signaling and Liver X Receptor/ Retinoid X Receptor (LXR/RXR) activation pathways. The most promising biomarkers were 35, altered in PCa when compared to more than one group. Half of these have confirmed localization in normal or PCa tissues. Twenty proteins (CD14, AHSG, ENO1, ANXA1, CLU, COL6A1, C3, FGA, FGG, HPX, PTGDS, S100A9, LMAN2, ITIH4, ACTA2, GRN, HBB, PEBP1, CTSB, SPP1) are oncogenes, tumor suppressors, and multifunctional proteins with highly confirmed involvement in PCa, while 9 (AZU1, IGHG1, RNASE2, PZP, REG1A, AMY1A, AMY2A, ACTG2, COL18A1) have been associated with different cancers, but not with PCa so far, and may represent novel findings. LC-MS/MS data are available via ProteomeXchange with identifier PXD008407. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, THE HISTOPATHOLOGICAL PROFILE OF ENDOMETRIAL SPECIMENS IN WOMEN WITH ABNORMAL UTERINE BLEEDING(MACEDONIAN ASSSOCIATION OF GYNECOLOGISTS AND OBSTETRICIANS, 2025-05); ; ; ; Islami Zulfiu, Arta - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Paget breast cancer immunoprofile as Toker's cells: a case report(Springer, 2018-09); ; Background&Objective: Paget's disease or Paget breast cancer is a rare and unusual breast cancer. The appearance of the disease may be associated with invasive or noninvasive tumour mass and rarely without an underlying neoplasm. The aim of this paper is to present a case of Paget’s carcinoma without an underlying carcinoma (PCWUC), arising from Toker's cells. Method: The patient was 70-years old woman with ulcerative and crusted changes of the nipple and areola. We examined a large number of sections taken from biopsy and surgical specimen of the nipple, areola and underlying breast tissue. All slices were processed and stained with standard procedures (haematoxylin–eosin) and immunohistochemical technique. Results: Epidermis and distal lactiferous channels were infiltrated with Paget cells resembling atypical neoplastic altered Toker's cells. Using immunohistochemistry, we found a clear demarcation between normal epithelial cells from malignant cells infiltrate. Cytokeratin 7 was positive only in tumour cells, but high molecular and low molecular weight cytokeratins were only positive in normal epithelial cells. Underlying breast tissue did not contain any tumour cells. Conclusion: The same immunoprofile of Toker's cells and PCWUC cells suggests a common histogenesis. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Body weight and crown-heel length autopsy standards in a Macedonian perinatal population: single centre experience(Springer, 2021); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Congenital Pulmonary Airway Malformation Type II and Challenge in the decision-making process in developing countries-a case report(Creative Commons Attribution License, MSD Publications, 2024-10-22); ; ; ; Aliji, NurieCongenital Pulmonary Airway Malformation (CPAM) is a congenital lung disease that can be present from prenatal to childhood. The overall incidence of CPAM is reported to be 1 in 10,000 to 1 in 35,000 births, making it the most common type of congenital lung lesion. This malformation results from the interruption of lung development during various stages of embryogenesis. This case report aims to illustrate the disease through ultrasound imaging, emphasize its characteristics, and discuss parental counseling and decision-making regarding the continuation of pregnancy. It is important to highlight the limitations of prenatal diagnostic precision in developing countries and the need for additional diagnostic tools to improve parental decision-making options