Sibinovska, Olgica
Preferred name
Sibinovska, Olgica
Official Name
Sibinovska, Olgica
Main Affiliation
Email
olgica.sibinovska@medf.ukim.edu.mk
13 results
Now showing 1 - 10 of 13
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Item type:Publication, COMPARISON OF TWO METHODS FOR SARS-COV-2 ANTIBODY TESTING(University Ss. Cyril and Methodius in Skopje, 2022); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, PREVALENCE OF ANTI-SARS-COV-2 IGG ANTIBODIES IN SKOPJE, NORTH MACEDONIA: TWO-TIME POINTS POPULATION-BASED CROSS-SECTIONAL STUDY(University Ss. Cyril and Methodius in Skopje, 2023); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, What is in a name and what is in the brain? -clinicians’ dilemmas in the biomarker era(Elsevier BV, 2025-05); ; This viewpoint draws analogy from Shakespeare’s query, "What’s in a name?" and explores what defines neurodegenerative diseases such as Parkinson’s (PD) and Alzheimer’s (AD) and what clinicians understand by that name in relation to the underlying brain pathology and disease biology. The inspiration comes from the latest biological definitions of PD revealing significant similarities with the biological definition of AD. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, HLA profile of the donors in the Macedonian Bone Marrow Donor Registry(Wiley Online Library, 2018-12); ; ; ; Aleksandar SenevThe importance of HLA alleles in the process of haematopoietic stem cell transplantation, especially the process of unrelated donor search, is enormous. Macedonian Bone Marrow Donor Registry was established in 2010 and has registered volunteer donors from different nationalities that live in the Republic of Macedonia. The aim of this study was to determine the HLA allele and haplotype frequencies of the volunteer donors from the Macedonian Bone Marrow Donor Registry and to compare this results with the Macedonians from a family study. We analyzed 1,541 donors, with different nationalities, Macedonian, Albanian and Macedonian Muslims that were most numerous in MBMDR, and typed them for HLA-A, -B, -C, -DRB1, whereas Macedonian also for HLA-DQA1 and HLA-DQB1 by SSO method (One Lambda, CA, USA). The most frequent alleles in Macedonians were HLA-A*02, 01, 24; HLA-B*35, 18, 51; HLA-C*07, 04, 12; HLA-DRB1*11, 16, 13; HLA-DQA1*01, 05 and HLA-DQB1*05, 03, 06; in Albanians they were HLA-A*02, 24,01; HLA-B*51, 18, 35; HLA-C*07, 04, 12, HLA-DRB1*11, 13,16; and in Macedonian Muslims they were HLA-A*02, 01, 24; HLA-B*18, 51, 35, HLA-C*07, 04, 02 and HLA-DRB1*11, 16, 14. The most common haplotype in Macedonian was HLA-A*01-B*08-C*07-DRB1*03, whilst in Albanian and Macedonian Muslims HLA-A*02-B*18-C*07-DRB1*11. The comparison of the HLA allele groups between Macedonian from MBMDR and family study showed similar distribution. This study confirmed the close relationship between the populations that live in the Balkan Peninsula. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Comparison of ELISA and chemiluminescence immunoassay methods for quantification of human Placental growth factor in serum(Croatian Society of Biologists in Health Care, 2020-06-01); ; ; Placental growth factor (PlGF) is crucial during placental development in early pregnancy. Several studies in pregnancies with complications such as preeclampsia or small for gestational age neonates find that PlGF levels are significantly lower in the first trimester, which implies that the concentration of PlGF could be used as an early screening biomarker for these conditions. This study aimed to compare the performance of chemiluminescence immunoassay (CLIA) and enzyme-linked immunosorbent assay (ELISA) for the quantification of human PlGF in serum. This is a comparative study on 88 pregnant women in the first trimester subjected to measurement of PlGF in serum using two commercially available kits: Human PlGF Quantikine HS ELISA (R&D Systems) and PlGF CLIA (Snibe). The overall coefficient of correlation between the tests was 0.93. When the cut-off value of 40 pg/mL was applied, it dropped significantly to 0.50 towards the lower values, while remaining an excellent 0.91 in the group with higher concentrations of PlGF. While R&D Systems’s ELISA seems to have better sensitivity, it is not very convenient to use for a small number of samples. Snibe’s CLIA automated method is user-friendly, fast and powerful. Both tests show excellent performance when indicating risk-free pregnancies. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, EFFECTS OF VALSARTAN AND AMLODIPINE ON PROINFLAMMATORY CYTOKINES SERUM CONCENTRATIONS IN SALT LOADED SPONTANEOUSLY HYPERTENSIVE RATS(Japanese Pharmacological Society, 2018); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, TYPE OF CYP450 2C19 GENE METABOLIZERS IN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION IN THE REPUBLIC OF NORTH MACEDONIA -A PILOT STUDY(University Ss. Cyril and Methodius in Skopje, 2022); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A single dose of BNT162b2 vaccine elicits strong humoral response in SARS-CoV-2 seropositive individuals(Wiley, 2022-01); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, HLA profile of the Macedonian, Albanian and Macedonian Muslim donors in the Macedonian Bone Marrow Donor Registry(Elsevier BV, 2019-09); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Incidence of β-lactoglobulin intolerance among lactose intolerance suspected population and diagnostic approach(Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2022-12-31); ; ; Milk and dairy products have high nutritional value due to its protein, vitamin, mineral and fatty acid content (FAO, 2013). However, regular usage of these products in some individuals may result in manifestation of adverse reactions, such as lactose intolerance (LI) and cow`s milk protein intolerance (CMPI). LI is a syndrome with primarily gastrointestinal symptoms as a result of lactase deficiency in the intestinal mucosa and lactose malabsorption. It can be genetically driven, known as primary LI, where homozygous LCT-13910C and LCT-22018G variants are coding low lactase activity, or secondary LI due to damaged mucosa. CMPI is an immune mediated reaction to milk`s proteins causing abdominal pain, diarrhea, vomitus, nausea etc. Since LI is highly prevalent in the population, while clinical features of LI and CMPI are similar, the last is often misdiagnosed. Treatment of both conditions is mainly based on food restrictions excluding lactose or cow`s milk proteins, so relevant diagnosis is important in successful disease management (Di Constanzo et al., 2019). The aim of this study was to determine the incidence of β-lactoglobulin intolerance (the most frequent form of CMPI) in LI suspected population and to identify diagnostic tools that can help to differentiate CMPI and LI.