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    BODY COMPOSITION RELATED TO BODY MASS INDEX AMONG YOUNG ELITE FOOTBALL PLAYERS
    (Medical faculty, Ss Cyril and Methodius University in Skopje, 2017)
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    Abstract Introduction. Body composition is extremely important for athletes’ performance, thus assessment tools may be used to clarify their sports condition. The aim of the study was to investigate body composition measurements and maximal oxygen consumption related to body mass index (BMI) in young elite football players. Material and methods. A total of 29 young football players were divided into 3 groups related to the value of BMI: I group (n=8); II group (n=13); and III group (n=8). The subjects were submitted to the sub-maximal pulse approach on treadmill method (SchillerAg, MTM-1500 Bear, Switzerland) to measure VO 2max (ml/kg/min). A body composition analyzer (InBody720, Biospace Co, Seoul, Korea) was used to determine the body fat - BF (%), skeletal muscle - SM (%) and total body water – TW(L) including intracellular body water – ICW(L) and extracellular body water – ECW(L). For the statistical analysis, a t-test was performed upon which the significance for p<0.05 was considered. Results. The football players showed the highest VO 2 max value in the II group (p<0.05). BF showed increased value in the III group (p<0.02). SM did not show any significant difference between the groups. Body water composition showed no statistical significance. Conclusion. Due to our results, we may conclude that certain parameters may determine the condition of young athletes in order to select appropriate training procedures, proper diet, and personalized performance. Key words: football; body mass index; body composition.
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    COMPARISONS AND CORRELATIONS OF THE ELECTROCARDIOGRAPHY CHANGES REGARDING THE FUNCTIONAL FEATURES BEFORE, DURING AND IMMEDIATELY AFTER THE TREADMILL TEST WITH ATHLETES
    (Faculty of Physical Education, Sport and Health in Skopje, 2019)
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    The need for cardiovascular screening in order to timely detect and diagnose the morphological and functional changes of the heart, which occur as a result of doing sport actively, and thus to avoid the occurrence of sudden cardiac death, is generally accepted. To achieve the objectives of the study, two noninvasive diagnostic methods for cardiovascular evaluation were used: electrocardiography (ECG) and the Bruce protocol test. The purpose of this study was to determine and examine the relationship of ECG changes to functional characteristics before, during, and/or immediately after exercise testing. This crosssectional study conducted during 2016/2017 involved 285 athletes aged 9 to 38, of both sexes. They were all given a 12-channel electrocardiogram (ECG) at rest, after which personal, family and sports history and anamnesis were given, followed by a Bruce protocol test and functional parameters were examined (symptoms, metabolic equivalents, METs, test duration, exercise capacity-VO2 max, rhythm disturbance, heart rate, heart rate reserve and recovery, chronotropic incompetence (CI), systolic and diastolic blood pressure). According to ECG changes and in accordance with international recommendations for its interpretation, athletes were divided into 4 groups: with normal, physiological, borderline or abnormal ECG findings. The results showed a significant positive connection between abnormal ECG and the occurrence of rhythm disturbance during the exercise test (r = 0.119; p = 0.045); Cardiovascular capacity expressed in (METs) compared to respondents with normal ECG was significantly higher in those with physiological ECG changes (p = 0.003), HR reserve percentage was lowest among athletes with abnormal ECG, and CI had the highest percentage. It can be concluded that an athlete with borderline, abnormal, and possibly physiologically assessed ECG should undergo further evaluation.
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    THE SIGNIFICANCE OF THE ELECTROCARDIOGRAPHIC SCREENING USED IN PREVENTION AND DETECTION OF PATHOLOGICAL CHANGES IN HEARTS OF ATHLETES
    (Faculty of Physical Education, Sport and Health, Skopje, Republic of Macedonia, 2022)
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    Abstract Changes in the structure and function of the heart that occur as a result of engaging in professional amateur training can be detected in a timely manner by using 12-channel electrocardiography (ECG) as one of the non-invasive methods used for cardiovascular screening in athletes.. The aim of the study is to promptly detect and diagnose cardiovascular conditions that can cause sudden cardiac death in athletes. In this prospective cross-sectional study conducted during 2016/2017, 285 examinees-athletes aged 9-38 years of both sexes were included (62,1% men and 37,9% women). An ECG was performed on all of them and a personal, sports and family history was taken. According to the ECG changes and in accordance with international recommendations for its interpretation, the examinees were divided into 4 groups. The results showed that physiological changes in the ECG were found in 51,9% of examinees, borderline changes in the ECG in 21,4%, while abnormal in 7,7%. Due to the possibility of timely identification and detection of heart changes due to physical activity or congenital, and could cause sudden cardiac death, the use of 12-channel electrocardiography is necessary in the evaluation of athletes. Key words: electrocardiography, sudden cardiac death, screening for cardiovascular disease, athletes
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    Red blood cell variables, their inter-correlations and correlations with body mass components in boys aged 10-17 years
    (Turkish National Pediatric Society, 2020-01)
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    Serjoza Gontarev
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    Daniela Shukova Stojmanovska
    Objective of this study was to analyze the hematological parameters, their inter-correlation and their correlation with body composition components in young male adolescent subjects.One hundred and ninety (190) physically active male subjects, aged 10 to 17 years, mean age 13.37 4.5 years, were included in the study. Capillary blood was taken from all subjects and the following hematological parameters were measured: red blood cell count (RBC); hematocrit (Ht); hemoglobin mass (Hb) and hematological indices (MCV,MCH, MCHC).The body components derived from Matiegka anthropometric method were assessed: muscular mass (MM%), bone mass (BM%), body fat mass (BF%). The mean values (SD) for hematological parameters were RBC= 5.070.41 x 1012/l,Hb=14.241.24 g/dl, Hct=43.833.8%. Anthropometric characteristics were as follows: BMI was 20.26 3.27 kg /m2, relative muscular mass (MM%) was 53.18 3.19 %, bone mass (BM%) was 18.83 2.4% and body fat percent (BF%) was 15.19 2.64 %. Correlation’s analysis between hematological parameters and body composition showed moderate to strong correlation between RBC, Hb and Hctand all body components. The strongest correlations were found between Hb and Hct and the muscular mass (r= 0.60; r= 0.61) and the lean body mass (r= 0.59).The hematological parameters are positively associated with all body mass components, while the strongest correlations were found between hemoglobin levels and hematocrit and skeletal muscle mass and lean body mass. The knowing and understanding of the relationship between RBC variables and body composition parameters could be important in healthcare planning for children.
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    Correlation of electrographic changes with sport activity characteristics and certain anthropometric characteristics in athletes.
    (Faculty of Medicine, University, Ss. Cyril and Methodius in Skopje, 2019)
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    ANTHROPOMETRICAL PARAMETERS OF OBESITY IN MACEDONIAN URBAN CHILDREN AGED 13-15 YEARS OLD
    (Medical faculty, Ss Cyril and Methodius University in Skopje, 2015)
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    The changes of ACTH, cortisol, testosterone and testosterone/cortisol ratio in professional soccer players during a competition half-season
    (Comenius University, School of Medicine - AEPRESS SRO, 2006-02)
    Handjiski, Zoran
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    Mickoska, E
    The following up of some hormonal parameters during the professional soccer training process could be one of the indicators of the training effects. On the other hand, overreaching and overtraining as an opposite adaptation of supercompensation could be detected by following up some hormonal changes. The aim of this study is to evaluate the changes in some hormonal parameters in professional soccer players during a half-season competition. We included 30 professional soccer players from a soccer club of our National Soccer League in this study. All sport medical examinations were conducted tree times: before the preparation phase, before the competition phase (after previous phase) and after finishing the competition phase. There were significant differences in all evaluated hormones between three phases of soccer training process, including significant decrease in T/C of more than 30% at the end of the competition phase (phase III). The decrease in muscle mass after the preparation phase and the increase in fat mass at the end of competition phase were insignificant. The hormonal changes indicated that some indices could indicate overreaching and overtraining at the end of professional soccer competition season. Although insignificant, the decrease in muscle mass after the preparation phase and the increase in fat mass at the end of competition phase were undesirable effects for us (Tab. 4, Fig. 2, Ref. 19).
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    Dual inhibition of angiotensin converting enzyme and neutral endopeptidase produces effective blood pressure control in spontaneously hypertensive rats
    (AEPress Bratislava, 2005)
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    Background: The synergistic effects of the combined ACE and NEP inhibition is based both on the blockade of angiotensin II synthesis and degradation of vasoactive peptides and NEP substrates (ANP, arginine, endothelial cells, guanylat cyclase etc.), including bradykinine and the natriuretic peptides, which contribute to vasodilatation, diuresis and improvement of myocardial function. Objectives: This study was undertaken to asses the hypotensive effect of a dual ACE/NEP inhibitor (omapatrilat) in comparison to a NEP inhibitor (candoxatril) and ACE inhibitor (enalapril) in SHRS. Methods: The study was performed in 130 male spontaneously hypertensive rats (SHRS) that were divided into 4 groups and treated orally by a gastric tube for 14 days according to the following dosage regimen: omapatrilat (40 mg/kg b.w./24 h); candoxatril (30 mg/kg b.w./24 h); enalapril (20 mg/kg b.w./ 24 h) and control (water). Systolic blood pressure values were determined at the beginning of the study by the tail-cuff pletysmographic method, at the 7th and 14th day of the treatment, as well as 14 days after the end of the drug administration. For evaluation of the effect of omapatrilat, candoxatril and enalapril on the investigated parameters (plasma atrial natriuretic peptide and serum ACE), 10 ani- mals from the control group were sacrificed at the beginning of the study, and afterwards 10 animals from each group were also sacrificed on the 7th and 14th day of the treatment, as well as 14 days after the end of the drug administration (28th day). Results: The dual ACE/NEP inhibitor, omapatrilat and the ACE inhibitor, enalapril lowered SBP more effectively than the NEP inhibitor, candoxatril at all time points of the experiment (p<0.01). Omapatrilat was slightly more effective than the enalapril treatment. Conclusions: Two-week treatment with the dual ACE/NEP inhibitor omapatrilat caused a significant decrease of the SBP, inhibition of the serum ACE activity and increase of the plasma ANP values, and therefore it should be considered as a new potential therapeutic agent in blood pressure management.
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    BIA analysis in sports anthropometry: segmental analysis in elite karate athletes
    (Anthropological Society of Serbia, 2018-05)
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    The aim of the study was to analyze the active components of the body composition in Macedonian karate athletes with bioelectrical impedance body analyzer. The sample was composed of twenty two (22) male karate athletes with the following characteristics (mean  SD): age=21.5  3.45 years; height= 178 cm  5.42; weight= 76.8  6.12 kg. Method: The analysis of the body components was made by the bioelectrical impedance analyzer (InBody 720). Results: Segmental analysis obtained by BIA measurement showed lean mass distribution in five body segments. The mean value of soft lean mass (SLM) was 63.91  7.32 kg. It was distributed as follows: right arm vs. left arm was 3.91 kg vs. 3.9 kg; right leg vs. left leg was 11.01  1.25 vs. 10.47  1.19 and trunk was 28.43  6.86 kg. Conclusions: Karate athletes check up their body composition continuously, especially before competitive events. The segmental distribution of the lean body mass is important for karatekas. Our results showed the mean values of lower limbs showed insignificantly higher values for right leg and the mean values of right and left arm were slightly different