Ilievski, Boro

Preferred name

Ilievski, Boro

Official Name

Ilievski, Boro

Main Affiliation

boro.ilievski@medf.ukim.edu.mk

Now showing 1 - 10 of 36

Some of the metrics are blocked by your
consent settings
Pigmented papillary carcinoma of male nipple mimicking melanoma
(Springer, 2021-08-31)
;
;
;
;
Background and objective: Primary melanomas of breast and carcinomas with pigment rich melanocytes are well known entities. Melanoma in nipple-areola complex is extremely rare and in differential diagnosis must be distinguished between Paget disease, melanoma from extramammary sites and other invasive carcinomas. We present a case of invasive papillary carcinoma of male nipple with melanin laden tumor cells. Methods: A 71-year old male patient presents with lobulated grayish tumor of the right nipple measuring 2x1, 3 cm elevated above the skin surface 1cm. The lesion was surgically removed with skin excision 0,7x 0,5x 0,5cm. The specimen was formalin-fixed and paraffin-embedded, routinely stained with HE. Additional immunohistochemical analysis was performed with CK7, ER, SMA, S-100, and Melan A. Results: The gross specimen on cut sections revealed solid white to brown tumor, well demarcated at the base and ulceration of overlying epidermis. Histomorphology of the sections showed papillary structures with tall columnar cells overlying fibrovascular cores, as well as micropapillary formations. There were areas of solid and cribriform growth pattern. Microcalcifications were diffusely present. There were accumulated melanophages in subepithelial tissue and melanin granules were also found in tumor cells. Immunohistochemical analysis showed that tumor cells were positive for CK7, with strong and diffuse nuclear stain for ER, with complete absence of myoepithelial cell on SMA stain. Melan A and S-100 were negative. Although rare, a diagnosis of pigmented papillary carcinoma was made. Conclusion: Pigmented carcinomas of breast are rare. When they are localized in areolar region the diagnosis should be carefully made to exclude lesions with melanocytic differentiation. The pigmentation should be considered also as a result by proximity to epidermis. The distinction between benign and malignant papillary lesions is quite difficult in most cases. The prognosis of patients with papillary carcinoma is relatively favorable.
Some of the metrics are blocked by your
consent settings
Platelet-rich plasma as a promising bioscaffold for enhancing peripheral nerve regeneration: An experimental study in a rat sciatic nerve model
(Journal of Biological Methods, 2025)
;
;
;
Aleksovski, Boris
;
Tusheva, Sofija
Despite advancements in surgical treatments, impairments persist after peripheral nerve injuries, prompting a shift in research toward the microenvironment of injured axons. Platelet-rich plasma (PRP), rich in growth factors and derived from autologous blood, emerges as a potential candidate to accelerate nerve healing.
Some of the metrics are blocked by your
consent settings
Low-Grade Malignancy Glomus Tumor in a Setting of Multiple Glomus Tumors - Case Report
(2019-12-15)
;
;
;
;
Glomus tumors are rare neoplasms accounting for less than 2% of all soft tissue tumors but multiple lesions may be seen in up to 10% of the patients. Solitary glomus tumor (GT) most frequently appears as small nodule in specific locations such as subungual region or deep dermis. However, rarely these entities have been observed in extracutaneous locations such as the gastrointestinal, cardiovascular, respiratory tracts, and other visceral organs. A small fraction of the GTs may present as tumors of uncertain malignant potential or as malignant glomus tumors.
Some of the metrics are blocked by your
consent settings
Role of the radiological variables, clinical picture and values of C-reactive protein (CRP) and leukocytes in the brain edema development and eary intrahospital mortality in patients with hemorrhagic cerebrovascular insult
(Macedonian Association of Physiologists and Antropologists, 2020)
Mihajlovska Rendevska, A
;
Aleksovski, B
;
;
Aleksovski, V
;
Stojanov, D
Introduction: The development of brain edema is one of the key factors that cause early neurological deterioration in patients with hemorrhagic cerebrovascular insult (H-CVI). In this study we analyzed the impact of: radiological variables (initial volume and volume of the 5th day of the intracerebral hematoma (IH), clinical state at admission (scored on appropriate scale), as well as nonspecific inflammatory markers (leukocyte count and C-reactive protein - CRP). on the development of brain edema and early in-hospital mortality, in patients with H-CVI. Material and methods: 26 conservatively treated patients with acute spontaneous intracerebral haemorrhage treated at the University Clinics of Neurosurgery and Neurology in Skopje. Computed tomography (CT) was used to evaluate radiological variables, the Canadian Stroke Scale (CSS) for neurological status scoring, as well as biochemical analysis of blood taken in the first 24 hours, to measure leukocyte counts and CRP level. Results: 8 of 26 patients (30.8%) were with lethal outcome. Initial volume of IH had the strongest effect on the development of perifocal edema, with less impact but statistically significant were: clinical status on admission and age of the patients. The strongest effect on early in-hospital mortality had all radiological variables (hematoma volume at admission and after 5 days, as well as volume of perifocal edema measured after 5 days).
Some of the metrics are blocked by your
consent settings
GANGLIOMA ASSOCIATED WITH FOCAL EPILEPSY
(Македонско лекарско друштво = Macedonian medical association, 2020)
;
;
Lejla Muaremoska Kanzoska
;
Learta Adili Ademi
;
Matilda Stojanovska
Although rare, gangliomas represent the most common tumor entity in young patients suffering from focal epilepsy [1,2]. The current World Health Organization (WHO) classi- fication defines ganglioglioma (GG) as a neoplasm com- posed of neural (ganglion cells) and glial elements, with both components being neoplastic [3].Ganglioglioma accounts for 0.4% to 9% of primary brain tumors and has been described in all parts of the central nervous system, but most commonly comes to clinical attention when present in the cerebral hemispheres, particularly in the temporal lobe [4,5]. We present a 13-year-old boy with repetitive focal seizures. The implemented EEG revealed right focus ofspike-wave complexes. Contrast-enhancedmagnetic resonance showed findings of TU lesion in the right middle temporal lobe. The patient underwent tumor excision. Patohistological diagnosis of the resected tu- mor was ganglioglioma. Postoperatively, the patient wasseizure-free, but the control EEG wasthe same asthe first EEG. In patients with ganglioglioma the appropriate treatment strategy involves not only the complete surgical extir- pation of the tumor, but also relatively early surgical intervention, because such an approach provides maxi- mum chance of an epilepsy cure [6].
Some of the metrics are blocked by your
consent settings
Liver pathology findings in infant with Caroli's syndrome
(Edorium Journals, 2012-02-28)
;
;
Duganovska, Snezana
;
Chadikovski, Vladimir
;
Introduction: Caroli's syndrome (CS) is a rare congenital disorder characterized by intrahepatic bile duct dilatation and congenital hepatic fibrosis. The clinical features of this condition include signs of portal hypertension, cholangitis and lithiasis. Liver transplantation is the ultimate treatment in most patients with liver failure. Case Report: A three month old infant treated with the diagnosis of biliary atresia, after two liver biopsies presented with distended abdomen, hepatosplenomegaly and signs of portal hypertension. Liver transplantation was preformed after four months. We found ectatic hilar bile ducts and intrahepatic bile duct dilatation. The pathologic finding of congenital hepatic fibrosis and proliferated dilated bile ducts suggested the diagnosis of Caroli's syndrome. Conclusion: Caroli's disease and Caroli's syndrome may represent single disorder distinguished by congenital hepatic fibrosis. Fibrosis itself leads to portal hypertension appearing late in patients with Caroli's disease while it's dynamic and progressive in CS. Elevated white blood cell count is due to recurrent cholangitis, cholestasis and hepatolithiasis. Caroli's disease can be associated with extrahepatic bile duct dilatation, but the exact incidence is not known. CS often is associated with kidney lesions and cardiac disease. Liver transplantation should be preformed early. Symptoms are presented early in life due to congenital and progressive hepatic fibrosis. Caroli's syndrome must be considered in differential diagnosis in neonates with jaundice, ascites and hepatosplenomegaly. The first child with liver transplantation in Republic of Macedonia was diagnosed as Caroli's syndrome.
Some of the metrics are blocked by your
consent settings
A novel mechanism and treatment target for presynaptic abnormalities in specific striatal regions in schizophrenia
(Springer Science and Business Media LLC, 2010-04)
Barakauskas, Vilte E
;
Beasley, Clare L
;
Barr, Alasdair M
;
Ypsilanti, Athena R
;
Li, Hong-Ying
Abnormalities of amount and function of presynaptic terminals may have an important role in the mechanism of illness in schizophrenia. The SNARE proteins (SNAP-25, syntaxin, and VAMP) are enriched in presynaptic terminals, where they interact to form a functional complex to facilitate vesicle fusion. SNARE protein amounts are altered in the cortical regions in schizophrenia, but studies of protein-protein interactions are limited. We extended these investigations to the striatal regions (such as the nucleus accumbens, ventromedial caudate (VMC), and dorsal caudate) relevant to disease symptoms. In addition to measuring SNARE protein levels, we studied SNARE protein-protein interactions using a novel ELISA method. The possible effect of antipsychotic treatment was investigated in parallel in the striatum of rodents that were administered haloperidol and clozapine. In schizophrenia samples, compared with controls, SNAP-25 was 32% lower (P=0.015) and syntaxin was 26% lower (P=0.006) in the VMC. In contrast, in the same region, SNARE protein-protein interactions were higher in schizophrenia (P=0.008). Confocal microscopy of schizophrenia and control VMC showed qualitatively similar SNARE protein immunostaining. Haloperidol treatment of rats increased levels of SNAP-25 (mean 24%, P=0.003), syntaxin (mean 18%, P=0.010), and VAMP (mean 16%, P=0.001), whereas clozapine increased only the VAMP level (mean 13%, P=0.004). Neither drug altered SNARE protein-protein interactions. These results indicate abnormalities of amount and interactions of proteins directly related to presynaptic function in the VMC in schizophrenia. SNARE proteins and their interactions may be a novel target for the development of therapeutics.
Some of the metrics are blocked by your
consent settings
Dilemmas concerning the diffuse axonal injury as a clinicopathological entity in forensic medical practice
(Elsevier, 2012)
;
;
;
;
Popevska, Z
Dilemmas and discussions concerning the diffuse axonal injury (DAI) and still existing in forensic medical practice are as it follows: 1. Whether the occurrence of DAI can indicate the type of traumatic event that has caused the head trauma, 2. Whether the presence of axonal damage in cases of hypoxia, ischaemia and other pathological conditions casts a shadow on the post-mortem pathological diagnosis of DAI and totally negates it, or there are certain clues in the findings that can point to the aetiology of the axonal damage. This paper discusses our findings based on neuropathological examination of 60 forensic cases of closed head injury. The neuropathological examination included: a macroscopic examination of the coronal sections and a microscopic examination involving an immunohistochemical method with antibody against β-amyloid precursor protein. Our findings indicate that DAI, as a clinicopathological entity, is undoubtedly an acceleration–deceleration injury, predominant in road traffic accidents as it is classically outlined, and cases of falling from a considerable height. Our findings point to a certain difference between the features of traumatic and ischaemic axonal damage. In this paper we also investigate the correlation between pathological grades of DAI and the impairment of the brain function before death.
Some of the metrics are blocked by your
consent settings
Metastatic ductal breast carcinoma in meningioma: A case report
(Springer, 2017-09)
;
Noveska Petrovska, B
;
Kocmanovska Petreska, S
;
Stojkovski, V
;
Objective: Meningiomas and breast cancers statistically are very common tumours among women. However, metastasis from breast carcinoma into an intracranial meningioma is extremely rare. We present a case of 66-years-old female patient diagnosed with breast tumour on physical exam 2 years prior, but refusing further treatment at that time. Method: After incidental fall from height the patient was admitted with vertigo and headaches. CT and MRI was performed which revealed temporoparietal extra-axial brain tumour measuring 7,4x6,3x4,8 cm and small diffuse post-contrast lesions suspicious for sarcoidosis. Surgery with fragmented excision and brain biopsy was performed. Gross examination showed hard white tumour parts with uniform cut surface. Standard procedure for histology and immunohistochemistry was made. Results: Microscopically the tumour was composed of spindle-shaped fibroblastoid cells with small areas of edema. On one sample from totally fifteen taken and on the samples from the brain biopsy, micro-metastatic foci resembling ductal breast carcinoma were detected. Immunohistochemical positivity for CK7, E-cadherin, ER, PR and strong HER with high Ki-67, confirmed the diagnosis. Conclusion: Tissue sampling plays great role in macroscopically undetectable lesions and patients without desire for cooperation. It is important to avoid overlooking the diagnosis of metastatic disease, taking into consideration the requirements for specific treatment strategy.
Some of the metrics are blocked by your
consent settings
Craniopharyngiomas: A 20-Year-Period Evaluative Single Center Study
(Scholars.Direct, 2021-06-21)
;
;
;
;
Cvetkovski, Petar
Introduction: Craniopharyngioma is a rare histologically benign brain tumor with potential malignant clinical course because of the high propensity of recurrence, deriving from the remnants of Ratkhe’s pouch, presenting as solid mass and partly as fluid-filled cyst. There are two main histological subtypes: adamantinomatous and papillary. The aim of this study is to evaluate statistical features of this tumor in the Republic of North Macedonia. Materials and Methods: This is a 20-year-period retrospective, single center evaluative study (1998-2018) of 40 craniopharyngioma cases operated in the University Clinic of Neurosurgery, diagnosed at the Institute of Pathology, Medical Faculty, University ‘’Ss. Cyril and Methodius’’ in Skopje, Republic of North Macedonia on paraffin section slides routinely stained with H&E. Statistica for Windows 7 was used. Results: From total 4929 cases of benign and malignant brain tumors, craniopharyngioma comprise 40 cases (0.81%); 25 (62.5%) males (37.9 ± 17.8 years), 15 (37.5%) females (34.0 ± 25.4 years), age 3 to 68 years; Most prevalent localization: Sellar region - 11 (27.5%), cerebrum - 8 (20%). Adamantinomatous - 27 (67.5%) cases, papillary 13 (32.5%) cases. Age group distribution: the most cases - 7 (17.5%) in 0-9, 40-49, 60-69 years groups; least cases - 3 (7.5%) in 20-29 years group. Nine (22.5%) of 40 patients have had recurrent tumor (first 1-3 years). Adamantinomatous was diagnosed in 14 (51.85%) males and 13 (48.15%) females; Papillary in 11 (84.62%) males and 2 (15.38%) females. There is significant statistical difference between age groups and craniopharyngioma subtypes (Kruskal-Wallis ANOVA: H = 14.86; p = 0.0274). Conclusion: We found association/correlation between gender, age and histological subtype. Papillary craniopharyngioma appears more frequently in males and adamantinomatous was most prevalent in younger patients.

Ilievski, Boro

Filters

Settings

Sort By

Results per page