Dohcheva Karajovanov, Ivana
Preferred name
Dohcheva Karajovanov, Ivana
Official Name
Dohcheva Karajovanov, Ivana
Main Affiliation
18 results
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Item type:Publication, Hydroxyurea Associated Cutaneous Lesions: A Case Report(Scientific Foundation SPIROSKI, 2018-08-20); ; ; ; Hydroxyurea (HU) is an antimetabolite agent that interferes with the S-phase of cellular replication and inhibits DNA synthesis, with little or no effect on RNA or protein synthesis. It is used in the treatment of many myeloproliferative disorders (MD) and is particularly a first line treatment drug for intermediate to high-risk essential thrombocythemia. Although safe and very well tolerated by the patients suffering from MD, there have been numerous reports of a broad palette of cutaneous side effects associated with prolonged intake of the medication. These may include classical symptoms such as xerosis, diffuse hyperpigmentation, brown-nail discolouration, stomatitis and scaling of the face, hands, and feet or more serious side effects such as actinic keratosis lesions, leg ulcers and multiple skin carcinomas. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Pediatric case of lichen planus pigmentosus inversus successfully treated with narrow band ultraviolet B phototherapy(Hindawi Limited/Wiley, 2020-11); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Pediatric case of lichen planus pigmentosus inversus successfully treated with narrow band ultraviolet B phototherapy(Wiley Online Library, 2020); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, CHRONIC WOUNDS - MICROBIOLOGY AND BIOFILM FORMATION(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2024); ; ; ; Ahtarova, BiljanaIntroduction: Chronic wounds are wounds that do not heal for more than 4 weeks. Among the most important causes of wound chronicity are wound infection, biofilm formation with microbial agents that are resistant to antimicrobial agents. Aim: To investigate microbial agents in chronic wounds, their potential to form biofilm. Material and methods: This was a prospective study involving 24 patients from the University Clinic for in Skopje. Microbiological swabs were taken from patients with chronic wounds on the lower extremities,and were analyzed at the Institute of Microbiology and Parasitology, Faculty of Medicine in Skopje. The biofilm formation potential in isolates was determined using the tissue culture plate (TCP) biofilm detection method. Results: In 17 patients, at least one microorganism was isolated from 23 wounds, a total of 36, and in 7 patients there was no positive isolate from 7 wounds. Eighteen wounds (60%) had an isolate with the potential to form a biofilm. The following microorganisms from the wound samples were recorded: 17 (47%) isolates of the genus Staphylococcus, 4 (11%) isolates each from the genera Proteusand Pseudomonas, 3 (8%) isolates each from Enterococcusand Escherichia, 2 (6%) isolates from Streptococcus, 1 (3%) each isolate from the genera Acinetobacter, Enterobacterand Candida albicans. Conclusion: In 60% of the isolates, a biofilm formation with different degrees was confirmed. A statistically significant association was found between the degree of wound healing and isolates with low potential for biofilm formation, as well as the type of isolate. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Toxic Epidermal Necrolysis: Case Report and Review(Scientific Foundation SPIROSKI, Skopje, Republic of Macedonia, 2024-03-12); ; ; ; Stevens–Johnson syndrome and toxic epidermal necrolysis (TEN) are severe mucocutaneous adverse drug reactions primarily caused by drugs. Characterized by fever, prodromal symptoms, and extensive epidermal sloughing with mucous membrane involvement (>90%), they are collectively termed epidermal necrolysis and are considered a disease continuum.CASE PRESENTATION: A65-year-old man presented with widespread erythema and distinctive target-like lesions, accompanied by ruptured flaccid vesicles on the extremities. Following a 4-week carbamazepine treatment for a previous cerebrovascular insult, hematological analysis revealed abnormalities. Amultidisciplinary team, including a neurologist, endocrinologist, and ophthalmologist, prescribed a 3-day course of intravenous immunoglobulin at 0.5g/kg and an initial dose of 300mg prednisolone for 3days, supported by additional therapy. Discharged after 3weeks, the rash completely resolved within 2months. CONCLUSION: TEN, a severe mucocutaneous condition with a 30% mortality rate, often results from drug exposure. Swift identification of the causative drug is crucial for optimal outcomes. Treatment primarily includes discontinuing the offending drug and offering supportive care for mucocutaneous lesions. Amultidisciplinary approach is vital based on organ system involvement. The effectiveness of pharmacological treatments, such as intravenous immunoglobulin and corticosteroids, is continually under evaluation. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Lindsay's Nails and Terry's Nails in End Stage Renal Disease - Case Series(Balkan Cities Association of Nephrology, Dialysis, Transplantation and Artificial Organs, 2021-02); ; ; ; Introduction. Nail changes occur as part of a single organ disease, multisystemic diseases or because of the intake of some medications. Chronic kidney disease (CKD) is associated with various nail abnormalities. Тo identify Lindsay’s nails and Terry’s nails in patients with end stage renal disease (ESRD) on maintenance he-modialysis (HD) and to determine the common anam-nestic, clinical and/or laboratory parameters that would help elucidate the etiopathogenesis of these nail pathology. Methods. Twenty patients with ESRD on hemodialysis were included into the study. Dermatological examina-tion took place during the dialysis session. Lindsay’s nails were identified when the distal part of the nail bed is red/rose-brown, clearly separated from the proxi-mal part of the nail bed, occupying 20-60% of the entire length of the nail bed. The proximal part of the nail bed is whitish, resembling grounded glass. When pressing the nail, the discoloration of the distal part of the nail bad does not fade completely. Terry’s nails were identified by a 0.5-3.0 mm wide distal band, pink-brown in color, with a proximal part of the nail bed that is white and occupies 80% of the entire nail bed. Data on demographic characteristics, history of the disease and the laboratory values were noted for each patient. Results. Out of 20 patients, all males, we diagnosed Half-and-Half nails, also called Lindsay’s nails, and Terry’s nails in 6(30%) patients [5 Half-and-Half nails (25%), and 1 with Terry’s nails (5%)]. All patients had sideropenic-free anemia, elevated urea and creatinine values and elevated parathyroid hormone (PTH) values (>190 pg/L, range 190.3-387.5 pg/L). Conclusion. After searching the relevant literature (MEDLINE, PubMed), we found this is the first study to link elevated PTH values and Half-and-Half nails (also called Lindsay’s nails), and Terry's nails in patients with ESRD on HD. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, MICROBIOME AND MYCOBIOME IN CHRONIC WOUNDS(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2023); ; Skin as the biggest organ with protective function in the human body, makes an equilibrium between microbial communities and immune system. Skin microbiome is defined as the genome of microorganisms found on the skin with which microorganisms have a complex relationship. Microbiota of healthy skin consists of resident and transient microorganisms. Two most common factors for delayed healing process in chronic wounds are infection and biofilm formation. Thus, it is important to analyze microbiome and mycobiome of chronic wounds. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, НОКТИТЕ НА LINDSAY И НОКТИТЕ НА TERRY КАЈ ПАЦИЕНТИ СО ХРОНИЧНА БУБРЕЖНА БОЛЕСТ СТАДИУМ 5 НА ХЕМОДИЈАЛИЗА – СЕРИЈА НА СЛУЧАИ(2022); ; ; Филиповиќ, ДејанЦел: Да се идентификуваат половина-и-половина но- ктите или уште наречени ноктите на Lindsay и ноктите на Terry кај пациентите со хронична бубрежна болест (ХББ) на хемодијализа (ХД) и да се утврдат заедничките анам- нестички, клинички и/или лабораториски параметри кои би помогнале во расветлување на етиопатогенезата на оваа ноктена патологија. Материјали и методи: 20 пациенти со ХББ стадиум 5 на хроничен хемодијализен програм беа вклучени во студијата. Дерматолошкиот преглед се одвиваше за време на дијализната сесија. Критериуми за дијагноза на поло- вина-и-половина нокти беа присуство на јасна граница помеѓу проксималниот и дисталниот дел од ноктеното лежиште, дисколорација на дисталниот дел со црвено/ розеникавo-кафеава пребоеност со афекција на 20-60% од целата должина на ноктеното лежиште и проксимален дел со белузлава пребоеност, налик на заматено стакло. При притисок на ноктот, дисколорацијата на дисталниот дел од ноктеното лежиште не бледее во целост. Ноктите на Terry се идентификуваа со наод на 0.5-3.0 мм широка дистална трака/лента, розево-кафеавкасто пребоена, со проксимален дел на ноктеното лежиште кој е белузлав и зафаќа 80% од целото ноктено лежиште. За секој пациент се нотираа податоците за демографските карактеристики (возраст и пол), за историјата на болеста (дијагноза на бубрежното заболување, стандардната терапија, време- траење на ХД) и за лабораториските вредности од меди- цинските истории [хемоглобин, феритин, калциум, фос- фор, албумини, креатинин, уреа и паратхормонот (PTH)]. Резултати: Кај 6/20 пациенти (30%), сите од машки пол, се дијагностицираа промени на ноктите од типот половина-и-половина нокти и ноктите на Terry. Кај 5 па- циенти се дијагностицираа половина-и-половина нокти (25%), а само кај 1 пациент се дијагностицираа ноктитена Terry (5%). Сите пациенти имаа анемија без сидеропе- нија, покачени вредности на уреа и креатинин и покачени вредности на паратхормонот (PHT) ( >190 pg/L, ранг 190.3 pg/L -387.5 pg/L). Заклучок: По пребарување на релевантната литера- тура (MEDLINE, PubMed), утврдивме дека ова е прва сту- дија во која се доведуваат во врска покачените вредности на РТН и промени на ноктите од типот половина-и-по- ловина нокти и нокти на Terry кај пациентите со ХББ на ХД. Секундарниот хиперпаратироидизам е основа да се постави хипотезата дека РТН со своето вазорелаксирачко и вазодилататорно дејство е одговорен за присуство на дилатиран венски плексус во ноктеното лежиште и црве- но-кафеавото пребојување на дисталниот дел од ноктот, додека белата боја на проксималниот дел од ноктите се должи на анемијата и депозитите на калциум во зидот на крвните садови. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Контактен дерматит на рацете кај здравствените работници во Македонија во тек на ковид-19 пандемијата(Лекарска комора на Република Северна Македонија, 2020-10); ; ; ; Neloska, LencheПандемијата со ковид-19 резултираше со потребата и препораките зазасилена хигиена и носење на заштитни ракавици. Тоа резултира со зачестена појава на контактен дерматит (КД)на рацете кај здравствените работници (ЗР), особено кај ониекои се директно вклучени во грижата за пациенти заболени со корона вирусот. Цел Да се истражи појавата на контактен дерматит нарацете кај здравствените работници кои не се директно вклучени во лекувањето на пациенти со ковид-19. Метод Беше спроведена интернет анкета кај 272 здравствени работницикои не се директно вклучени во грижата за пациенти со ковид-19, на територијата на цела Македонија. Анкетата содржеше прашања за појава на промени на кожата на рацете и фактори кои влијаат на тоа. Резултати Во тек на епидемијата соковид-19, контактен дерматит на рацете забележале 132 (49%) од испитаниците, од нив 110 (53.9%) се лекари. Оваа појава е почеста кај здравствените работницивработени во секундарназдравствена заштита (56 или 47%) и нехируршките гранки (92 или 52.5%). Заклучок Зголемената хигиена на рацете, употребата на алкохолни дезинфициенси, како и ретката примена на емолиенти, се поврзани со појава наконтактен дерматиткај здравствените работници. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, LONGSTANDING, REPETITIVELY MISDIAGNOSED KYRLE’S DISEASE IN A PATIENT WITH END-STAGE RENAL DISEASE: A CASE REPORT(University Ss. Cyril and Methodius in Skopje, 2023); ; ; Kyrle’s disease (KD) is a rare variant of acquired perforating dermatosis (APD), associated with systemic diseases in adults, particularly chronic kidney disease (CKD) and diabetes mellitus (DM). Hyperkeratotic papules of KD are clinically important as a sign of a systemic disorder that are often misdiagnosed, so clinicopathological correlation is needed to establish the diagnosis. We report a rare case with longstanding KD, associated with end-stage renal disease (ESRD) on hemodialysis for 25 years that was repetitively misdiagnosed as folliculitis, excoriations and prurigo nodularis. The KD skin changes started to develop during earlier stages of CKD, before the kidney disease was suspected, and continued to appear in flares with extensive lesions when the systemic disease in the background was not under control. Dermoscopy revealed a 3-zonal concentric pattern, characterized by bright whitish scales in the centre, a structureless whitish-grey area surrounding the central crusts, and a peripheral, rose/brown pigmentation. Histopathological examination revealed moderately acantathotic epidermal invagination filled with a keratotic plug admixed with cellular debris and neutrophils, and a modest parakeratosis. Our goal is to emphasize that the accurate and timely diagnosis is vital to be able to monitor patients for a life threating, systemic disease such as kidney failure, and attaining better management of the dermatological status which can become longstanding and hindering, as well as to outline the importance of the multidisciplinary approach to improve outcomes in patients affected by KD.