Kirijas, Meri
Preferred name
Kirijas, Meri
Official Name
Kirijas, Meri
Main Affiliation
Email
meri.kirijas@medf.ukim.edu.mk
23 results
Now showing 1 - 10 of 23
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Item type:Publication, The most frequent HLA alleles around the world: A fundamental synopsis(Elsevier BV, 2024-06) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Association between 22 cytokine gene polymorphisms and dilated cardiomyopathy in Macedonian patients(2009-11); ; Inflammation is an important component in the pathogenesis of many cardiovascular diseases and one of the commonest mechanisms in cardiomyopathy. There have been several studies on the cytokine polymorphism and dilated cardiomyopathy (DCM), but the results obtained were contradictory. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, COMPARISON OF TWO METHODS FOR SARS-COV-2 ANTIBODY TESTING(University Ss. Cyril and Methodius in Skopje, 2022); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, PREVALENCE OF ANTI-SARS-COV-2 IGG ANTIBODIES IN SKOPJE, NORTH MACEDONIA: TWO-TIME POINTS POPULATION-BASED CROSS-SECTIONAL STUDY(University Ss. Cyril and Methodius in Skopje, 2023); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, HLA profile of the donors in the Macedonian Bone Marrow Donor Registry(Wiley Online Library, 2018-12); ; ; ; Aleksandar SenevThe importance of HLA alleles in the process of haematopoietic stem cell transplantation, especially the process of unrelated donor search, is enormous. Macedonian Bone Marrow Donor Registry was established in 2010 and has registered volunteer donors from different nationalities that live in the Republic of Macedonia. The aim of this study was to determine the HLA allele and haplotype frequencies of the volunteer donors from the Macedonian Bone Marrow Donor Registry and to compare this results with the Macedonians from a family study. We analyzed 1,541 donors, with different nationalities, Macedonian, Albanian and Macedonian Muslims that were most numerous in MBMDR, and typed them for HLA-A, -B, -C, -DRB1, whereas Macedonian also for HLA-DQA1 and HLA-DQB1 by SSO method (One Lambda, CA, USA). The most frequent alleles in Macedonians were HLA-A*02, 01, 24; HLA-B*35, 18, 51; HLA-C*07, 04, 12; HLA-DRB1*11, 16, 13; HLA-DQA1*01, 05 and HLA-DQB1*05, 03, 06; in Albanians they were HLA-A*02, 24,01; HLA-B*51, 18, 35; HLA-C*07, 04, 12, HLA-DRB1*11, 13,16; and in Macedonian Muslims they were HLA-A*02, 01, 24; HLA-B*18, 51, 35, HLA-C*07, 04, 02 and HLA-DRB1*11, 16, 14. The most common haplotype in Macedonian was HLA-A*01-B*08-C*07-DRB1*03, whilst in Albanian and Macedonian Muslims HLA-A*02-B*18-C*07-DRB1*11. The comparison of the HLA allele groups between Macedonian from MBMDR and family study showed similar distribution. This study confirmed the close relationship between the populations that live in the Balkan Peninsula. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Systemic inflammatory profile in patients with chronic obstructive pulmonary disease(Macedonian Association of Anatomists and Morphologists, 2024-05-01); ; ; Chronic obstructive pulmonary disease(COPD)is heterogeneous condition with various phenotypes that have their own pathogenetic mechanisms and certain inflammatory mediators, as C-reactive protein, interleukins, circulating leukocytes. Uncovering the inflammatory profile may identify disease biomarkers. We aimedto compare the values of systemic inflammatory parameters in patients with different clinical phenotypes and determine their correlation with clinical parameters.In 30 COPD patients weanalyzeddemographic and clinical data, history of allergies, cigarette smoking and history of exacerbations. We phenotyped them intonon-exacerbator, exacerbator and COPD with asthma phenotype. COPD assessment test, modified dyspnea scale and the BODE (Body mass index, Obstruction, Dyspnea, Exercise capacity) index werecalculated. Spirometry and lung X-ray were performed. Peripheral blood was taken for analysis of inflammatory parameters.There were 16 patients(53.33%) with phenotype of non-exacerbator, and 7 (23.33%) with exacerbatorand COPD with asthma phenotype each. COPD assessment testhadsignificantly lowestvalue in non-exacerbator and modified dyspnea scalesignificantly highest value in exacerbatorphenotype. Therewere no mild gradepatientsin exacerbator,andno very severe grade in nonexacerbatorphenotype. C-reactive proteinand interleukin 8 had significantly lowest value in non-exacerbator; leucocytes significantly highest value in exacerbator; eosinophyls and interleukin 4 significantly highest value in COPD with asthma phenotype. There was no significant difference among the three phenotypes in neutrophyls andinterleukin 18. The three clinical phenotypes: non-exacerbator, exacerbator and COPDwith asthma have their own specific clinical and inflammatory features that have clinical, prognostic and therapeutic implications - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Comparison of ELISA and chemiluminescence immunoassay methods for quantification of human Placental growth factor in serum(Croatian Society of Biologists in Health Care, 2020-06-01); ; ; Placental growth factor (PlGF) is crucial during placental development in early pregnancy. Several studies in pregnancies with complications such as preeclampsia or small for gestational age neonates find that PlGF levels are significantly lower in the first trimester, which implies that the concentration of PlGF could be used as an early screening biomarker for these conditions. This study aimed to compare the performance of chemiluminescence immunoassay (CLIA) and enzyme-linked immunosorbent assay (ELISA) for the quantification of human PlGF in serum. This is a comparative study on 88 pregnant women in the first trimester subjected to measurement of PlGF in serum using two commercially available kits: Human PlGF Quantikine HS ELISA (R&D Systems) and PlGF CLIA (Snibe). The overall coefficient of correlation between the tests was 0.93. When the cut-off value of 40 pg/mL was applied, it dropped significantly to 0.50 towards the lower values, while remaining an excellent 0.91 in the group with higher concentrations of PlGF. While R&D Systems’s ELISA seems to have better sensitivity, it is not very convenient to use for a small number of samples. Snibe’s CLIA automated method is user-friendly, fast and powerful. Both tests show excellent performance when indicating risk-free pregnancies. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, EFFECT OF SUPPLEMENTAL ANTIOXIDANT-BASED THERAPY ON THE OXIDATIVE STRESS LEVEL IN COVID-19 PATIENTS(Македонска академија на науките и уметностите, Одделение за медицински науки = Macedonian Academy of Sciences and Arts, Section of Medical Sciences, 2023-03-15); ; ; ; Background: COVID-19 is a disease in several stages starting with virus replication to dysregulation in immune system response, organ failure and recovery/death. Our aim was to determine the effect of Ganoderma lucidum, lycopene, sulforaphane, royal jelly and resveratrol extract on markers of oxidative stress, inflammation, routine laboratory analyses and duration of symptoms in COVID-19 patients. Methods: The oxidative stress parameters and interleukines 6 and 8 (IL-6, IL-8), tumor necrosis factor alpha (TNF-α) were determined in order to estimate the antioxidant and the anti-inflammatory effect of the product using a spectrophotometric and a magnetic bead-based multiplex assay in serum of 30 patients with mild form of COVID-19. Results: Statistically significant differences were obtained for all investigated parameters between the treated patients and the control group. Moreover, significant differences were observed for leukocytes, neutrophil to leukocyte ratio and iron. The average duration of the symptoms was 9.4±0.487 days versus 13.1±0.483 days in the treatment and the control group, respectively (p=0.0003). Conclusion: Our results demonstrated the promising effect of Ge132+NaturalTM on reducing the oxidative stress and the IL-6, IL-8 and TNF-α levels, and symptoms duration in COVID-19 patients. The evidence presented herein suggest that the combination of Ganoderma lucidum extract, lycopene, sulforaphane, royal jelly and resveratrol could be used as a potent an adjuvant therapy in diseases accompanied by increased oxidative stress and inflammation. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Comparative analysis of global practices in the management of colchicine-resistant familial Mediterranean fever: a CliPS network analysis(BMJ Publishing Group Ltd, 2025-09-26) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Distribution of killer cell immunoglobulin-like receptor genes in Roma from Republic of Macedonia(Wiley Online Library, 2011-12); ; ; S. HristomanovaThe aim of this study was to analyze Killer Ig-Like Receptor (KIR) gene polymorphisms in Roma people from Republic of Macedonia. The studied sample consists of 103 healthy unrelated individuals, aged 20-45 years. All individuals are of Roma origin, residents of different geographical regions (Gostivar, Skopje, and Kochani). The population genetics analysis package, Arlequin, was used for analysis of the data. We found that all 16 KIR genes were observed in the Roma individuals and framework genes (KIR3DL3, KIR3DP1, KIR- 2DL4, and KIR3DL2) were present in all individuals. The frequencies of other KIR genes were: KIR2DP1 (1), KIR2DL1 (0.961), KIR2DL2 (0.544), KIR2DL3 (0.874), KIR2DL5 (0.311), KIR3DL1 (0.990), KIR- 2DS1 (0.330), KIR2DS2 (0.553), KIR2DS3 (0.359), KIR2DS4 (0.981), KIR2DS5 (0.291), and KIR3DS1 (0.379). The results of tested linkage disequilibrium (LD) among KIR genes demonstrated that KIR genes present a wide range of linkage disequilibrium. The obtained results for KIR genes and genotype frequencies in Macedonian Roma individuals can be used for anthropological comparisons.
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