Stankov, Aleksandar

Preferred name

Stankov, Aleksandar

Official Name

Stankov, Aleksandar

Main Affiliation

astankov@medf.ukim.edu.mk

Now showing 1 - 10 of 50

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Reliable and durable Golgi staining of brain tissue from human autopsies and experimental animals
(Elsevier BV, 2014-06-15)
Rosoklija, Gorazd B
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Petrushevski, Vladimir M
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Dika, Ani
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Golgi stains are notoriously capricious, particularly when applied to human brain. The well-known difficulties, which include complete failure of impregnation, patchy staining, unstable staining, and extensive crystalline deposits in superficial sections, have discouraged many from attempting to use these techniques. A reliable method that produces uniform impregnation in tissue from human autopsies and experimental animals is needed.
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Comparative study of two dna extraction methods in different tissues and conditions of degradation
(Elsevier BV, 2015-12)
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Air gun injury with deadly aftermath – Case report
(Elsevier BV, 2013-01)
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Muric, Nedzat
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Dwork, Andrew J.
In Republic of Macedonia the use of air guns is quite widespread. They are used mainly for target practice. They are regulated by the Law of Arms, where they are defined as pneumatic weapons. There is no legal limit on type or quantity of ammunition that one may possess. Our Institute performs at least 90% of the forensic autopsies in Macedonia. In this report we describe the only fatality by pneumatic weapon to come to our attention over the past 10 years. A 6-year-old girl was accidentally wounded by her brother when he and his father were trying a new air gun, a 4.5 mm single shot, break barrel, spring piston air rifle manufactured in China under the brand ‘‘Westlake’’. She died within minutes. Autopsy showed cardiac tamponade due to penetration of the aorta. A 0.5 g metal projectile, 4.5 mm in diameter, with a pointed, conical shape, was recovered from the pericardial sac.
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Blood Vessels and Perivascular Phagocytes of Prefrontal White and Gray Matter in Suicide
(Oxford University Press (OUP), 2019-01-01)
Schnieder, Tatiana P
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Zhou Qin, Isaiah D
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Trencevska-Ivanovska, Iskra
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Rosoklija, Gorazd
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Inflammatory processes may contribute to psychiatric disorders and suicide. Earlier, we reported greater densities of perivascular phagocytes in dorsal prefrontal white matter (DPFWM) in suicide than in non-suicide deaths. To distinguish between greater vascularity and greater coverage of vessels by perivascular phagocytes, and to determine whether the excess of perivascular phagocytes is derived from microglia or from non-parenchymal immune cells, we made stereological estimates of vascular surface area density (AVTOTAL) by staining for glucose transporter Glut-1, and the fraction of vascular surface area (AF) immunoreactive (IR) for CD163 (CD163 AF) in dorsal and ventral prefrontal white and gray matter. Manner of death or psychiatric diagnosis showed no association with CD163 AF in any region. Suicide was associated with a lower AVTOTAL compared with non-suicides in DPFWM (p = 0.018) but not with AVTOTAL in the 3 other regions of interest. Thus, the earlier observation of increased density of perivascular phagocytes in DPFWM after suicide cannot be attributed to infiltration by peripheral monocytes or to increased vascularity. Greater AVTOTAL ventrally than dorsally (p = 0.002) was unique to suicide and white matter.
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Incidence and Prevalence of Vaginal Infections in Women of Reproductive Age in North Macedonia
(Macedonian Academy of Sciences and Arts/Walter de Gruyter GmbH, 2023-07-01)
Albig, Jovana
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Micevska, Megi
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Jovchevski, Sasha
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In the available literature on this subject there are many studies which describe the effects of sexually transmitted infections on pregnancy and fertility of women. Because of the frequency of the infections with the atypical bacteria of the Ureaplasma Spp., Mycoplasma Spp., Chlamydia Trachomatis, as well as HPV infections in women of reproductive age, it is easy to underestimate their importance when establishing the basis of the genital health of women of reproductive age. In this prospective analysis, conducted from 2014 to 2018 in the laboratory for HPV and Molecular diagnostics at the University Clinic of Gynaecology and Obstetrics in Skopje, North Macedonia, we analysed the results of 10,387 patients of all ages, of which 973 patients were of reproductive age. A Panel analysis was also conducted (including the above-mentioned pathogens). An HPV analysis was also conducted on 643 patients in this group. Within the group of 643 patients, there was a positive result for HPV in 26.7% of them, while in 40.9% there was a positive result for one or more pathogens on the Panel analysis of bacterial pathogens. The statistical analysis of the results showed that the most frequent of all bacterial pathogens within the Macedonian population of women of reproductive age is Ureaplasma Spp, with an incidence of 33%, followed by Mycoplasma Spp., with 7.8%, while Chlamydia Trachomatis was present in 6.4% of the cases. We should highlight that a co-infection with HPV was present in 18.5% of all the patients where there was analysis of both diagnostic procedures. The analysis of the results in the patients co-infected with HPV and at least one bacterial pathogen on the Panel Analysis, showed a very high statistical correlation (p<001).
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The role of alcohol and patterns of alcohol-related deaths in Republic of North Macedonia within the period 2007-2020
(Springer Link, 2023-11-10)
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Zhivikj, Zoran
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Excessive alcohol consumption is one of the most important factors in a substantial number of violent deaths. The aim of our study was to investigate alcohol-related deaths in the Republic of North Macedonia in the period from 2007 to 2020, in order to study the influence of elevated blood alcohol levels in violent deaths. Five hundred sixty-four post-mortem blood samples from alcohol-related death cases-natural deaths and violent deaths (suicides, accidents, and homicides)-were analyzed, and the results were evaluated according to sex, age, and cause of death. Among 564 cases, traffic accidents were the leading cause of violent death (54.3% of the cases) followed by suicides (19.9% of the cases). In the examined post-mortem samples, BAC values ranged from 0.15-6.20 g/L. The average age was 45 ± 16 years for the male and 49 ± 19 years for the female group. The biggest proportion of high BAC values was found in the group of accidents specifically road traffic accidents and accidental intoxication as well as in the group of bolus deaths. The analysis of BAC in the cases of violent deaths in the Republic of North Macedonia confirmed that consumption of alcohol is strongly related to violent deaths. The data obtained from this study could raise caution and give aid in a national strategy for the prevention of alcohol-related violent deaths.
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INFORMED CONSENT IN GENETIC REASEARCH
(Macedonian Association of Anatomists and Morphologists, 2023)
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Recognizing the ethical, legal, and social implications (ELSI) of genetic testing becomes crucial for physicians in the face of complex medical issues, as they are increasingly expected to counsel their patients regarding the medical, psychological, and social responses arising from genetic information. Genetic medicine, with its extreme complexity and the potential repercussions on an individual's life, raises important questions in the ethical, deontological, and legal realms of medicine, playing a primary role in personalized medicine. The aim of this paper is to underscore the significance of informed consent and to provide insights into the ethical procedures associated with genetic testing.
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Consent form, the highest ethical standard in creating DNA databases for criminal investigation
(Elsevier BV, 2022-12)
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Donevska-Stefanov, Pavlinka
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Janevski, Robert
Preparation of DNA databases for the purpose of criminal investigation opens discussions about ethical-legal issues concerning violation of human rights. The practice shows that one of the human rights that can be misused while creating such a database is the right to freedom, the freedom to make a decision. When preparing DNA databases, the right to freedom refers to free decision of the person to be sampled for carrying out the test. The right to freedom and respect to self-determination of the person implies the necessity of prior consent of the subject when preparing a database on general population level. This is not a case when databases are created from persons under investigation for committing a crime, who are compulsory subjected for obtaining samples for DNA analysis. Legal regulations approve the duty of the police and its authorization in collecting samples for personal or criminalistic identification, analyzing, keeping and eliminating collected personal information when criminal prosecution is concerned. In these cases, consent form from the subject is not necessary. However, we should be aware that the process of taking and collecting of personal information by the national institutions can have direct impact of privacy of the subject, no matter if this information is going to be used or not. In purpose of fair balance between public and private interest, consent form can be redefined and the person from whom the biological material is provided will be unequivocally made aware of the purposes for which his genetic data will be used, how long his DNA will undergo further automated processing, and about the procedure and under what conditions his DNA profile can be removed from the national DNA databases.
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TIME-DEPENDENT EXPRESSION OF IL-1β mRNA - A PRELIMINARY STUDY FOR POSSIBLE WOUND AGE MARKER
(Macedonian Association of Anatomists and Morphologists, 2023)
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Siamkouri, Rosica
Accurate estimation of wound age is a very important task in forensic medicine field, because it can helps in reconstruction of crime scene. IL-1β is proinflamatory cytokine and plays a major role in wound healing process. The aim of the study is to develop a method for the reliable estimation of dermal injury age. In this study the expression of IL-1β mRNA was evaluated by real-time PCR at skin human wounds with different post-injuried period. We collected 27 human skin wound samples from forensic autopsy cases at our Institute. In our study were include samples from lacerations, incised wounds and stab wounds, with a known time of injury and death. Wound samples were divided into five groups: control group (n=5); first group consisted of cases with immediate death (n=7); second group consisted of cases with survival from 1 hour to 6 hours (n=5); the third group comprised cases with survival from 6 hours to 72 hours (n=3); the fourth group comprised cases with survival from 72 hours to 168 hours (n=7). In this study we detected increased expression levels of IL-1 β mRNA in the second group with survival time from 1 to 6 hours.
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Објективноста на вештачењето - основно начело на лекарот-вештак
(Македонско Лекарско Друштво, 1999-10)
Duma, Aleksej
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Gutevska, A.

Stankov, Aleksandar

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