Faculty of Natural Sciences and Mathematics

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Evaluation of immunoconjugates of non-radioactive lutetium- and yttrium-rituximab – a vibrational spectroscopy study
(Society of Chemists and Technologists of Macedonia, 2015-11-12)
Gjorgieva Ackova, Darinka
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Smilkov, Katarina
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Janevik-Ivanovska, Emilija
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Stafilov, Trajče
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Arsova-Sarafinovska, Zorica
<jats:p>Fourier Transform Infrared (FT-IR) and Raman spectroscopy were used to study the molecular structure of the recombinant monoclonal antibody and anti-CD20-conjugates which are intended to be used as anti-cancer therapeutic agents. We characterized the secondary structure of a therapeutic immunoconjugates, formulated with different bifunctional chelating agents and labeled with non-radioactive lutetium and yttrium. The secondary structure content of all three immunoconjugates was assessed to be similar to that of unlabeled antibody. In addition, no significant changes upon lyophilizing procedures were observed. The results demonstrate that amide bands could be taken as analytical peak which enables quick and reliable way for screening of protein pharmaceuticals during development of lyophilized formulations.</jats:p>
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Multi-element analysis of Macedonian wines by inductively coupled plasma–mass spectrometry (ICP–MS) and inductively coupled plasma–optical emission spectrometry (IP–OES) for regional classification
(Society of Chemists and Technologists of Macedonia, 2013-12-01)
Ivanova-Petropulos, Violeta
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Wiltsche, Helmar
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Stafilov, Trajče
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Motter, Herber
<jats:p>Major, minor, and trace elements in wines from the Republic of Macedonia were determined in this study. Both inductively coupled plasma–mass spectrometry (ICP-MS) and inductively coupled plasma– optical emission spectrometry (ICP-OES) were used for accurate determination of the concentration of 42 elements (Ag, Al, Au, B, Ba, Be, Bi, Ca, Cd, Ce, Co, Cu, Dy, Er, Eu, Fe, Ga, Gd, Ge, Ho, La, Lu, Mg, Mn, Mo, Na, Nd, Ni, P, Pb, Pr, S, Sm, Tb, Ti, Tl, Tm, U, V, Yb, Zn, Zr) in 25 Macedonian white, rose, and red wines from different wine regions. By means of factor and cluster analyses, the wines were discriminated according to wine type (white vs. red) and geographical origin. The main discriminant elements were B, Ba, Ca, Fe, Mg, Mn, P, and S. </jats:p>
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Microencapsulation of Lactobacillus casei in chitosan-Ca-alginate microparticles using spray-drying method
(Society of Chemists and Technologists of Macedonia, 2012-06-15)
Petreska Ivanovska, Tanja
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Petruševska-Tozi, Lidija
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Dabevska Kostoska, Margita
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Geškovski, Nikola
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<jats:p>In this study, the probiotic Lactobacillus casei was microencapsulated using the method of spray-drying combined with polyelectrolyte complexation of alginate, fructooligosaccharide and chitosan, and cross-linking with calcium chloride, followed by freeze-drying. Survival rate and physicochemical properties of the prepared microparticles were evaluated. In addition, viability of Lactobacillus casei in simulated gastric and intestinal juices was investigated. Positively charged microparticles with average size of 11.08±1.1 μm and high cell viability of 10.98±0.11 log cfu/g were prepared. The synbiotic microparticles were stable during exposure to simulated gastric and intestinal juices, while release of viable cells above the therapeutic value (8.31±0.14 log cfu/g) in the simulated colonic pH was observed.The presented method for microencapsulation of synbiotics shows potential for effective protection of viable probiotic cells during exposure to harsh environmental conditions.</jats:p>
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Microencapsulation of Lactobacillus casei in chitosan-Ca-alginate microparticles using spray-drying method
(Society of Chemists and Technologists of Macedonia, 2012-06-15)
Petreska Ivanovska, Tanja
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Petruševska-Tozi, Lidija
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Dabevska Kostoska, Margita
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Geškovski, Nikola
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<jats:p>In this study, the probiotic Lactobacillus casei was microencapsulated using the method of spray-drying combined with polyelectrolyte complexation of alginate, fructooligosaccharide and chitosan, and cross-linking with calcium chloride, followed by freeze-drying. Survival rate and physicochemical properties of the prepared microparticles were evaluated. In addition, viability of Lactobacillus casei in simulated gastric and intestinal juices was investigated. Positively charged microparticles with average size of 11.08±1.1 μm and high cell viability of 10.98±0.11 log cfu/g were prepared. The synbiotic microparticles were stable during exposure to simulated gastric and intestinal juices, while release of viable cells above the therapeutic value (8.31±0.14 log cfu/g) in the simulated colonic pH was observed.The presented method for microencapsulation of synbiotics shows potential for effective protection of viable probiotic cells during exposure to harsh environmental conditions.</jats:p>
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Study of organochlorine pesticide residues in water, sediment and fish tissue in Lake Ohrid (Macedonia/Albania)
(Society of Chemists and Technologists of Macedonia, 2011-12-05)
Veljanoska-Sarafiloska, Elizabeta
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Jordanoski, Momčula
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Stafilov, Trajče
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<jats:p>A systematic study has been performed for determination of a range of organochlorine pesticides in the water, sediments and fish samples in the Macedonian part of the Lake Ohrid and its larger tributaries. The obtained results give an overview of the contamination levels of these problematic compounds (i) at their potential sources in the river mouths, (ii) in the potentially affected, species-rich littoral section of the lake, and (iii) in the muscle tissue of one selected fish species Barbus peloponnesius, Valenciennes, collected near the rivers’ deltas. The organochlorine pesticides measured in all three matrixes were: γ-HCH, ΣHCH (sum of α-isomer, β-isomer and δ-isomer), endosulfan (total of α and β endosulfan), DDT metabolites (p,p’-DDE, p,p’-DDD and p,p’-DDT). The range of the observed concentrations for p,p’-DDT was between 0.006 μg l–1 in the water samples from Daljan and St. Naum and 0.036 μg l–1 in the water from the Koselska River. The values for p,p’-DDT measured in dry sediment ranged from 0.121 μg kg–1 in the sample from St. Naum to 1.8 μg kg–1 in the dry sediment from the Velgoška River and between 0.553 μg kg–1 for total endosulfan and 5.982 μg kg–1 for p,p’-DDE of wet fish biomass. The most abundant of the detected organochlorine pesticides was the sum of DDT metabolic forms, i.e. p,p’-DDT, p,p’-DDE and p,p’-DDD. The detected concentrations are clearly below toxic thresholds and consequently severe effects on the endemic species of Lake Ohrid are not very likely.</jats:p>
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Dissolved inorganic antimony, selenium and tin species in water samples from various sampling sites of river vardar in Macedonia and Greece
(Society of Chemists and Technologists of Macedonia, 2011-12-05)
Serafimovska, Jožica Majda
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Arpadjan, Sonja
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Stafilov, Trajče
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Ilik Popov, Stanko
<jats:p>A highly effective liquid phase semi-microextraction procedure was applied for determination ofultra trace levels of dissolved inorganic species of antimony, tin and selenium in river Vardar (from the 2ndup to 420th km of the river) and its tributaries Crna Reka, Treska, Bregalnica, Pchinja and Lepenec usingelectrothermal atomic absorption spectrometry (ETAAS) for quantification. The concentrations for totaldissolved inorganic antimony were between 6 and 242 ng/l Sb, for Sn(II, IV) – in the range of 2.7–61 ng/lSn and for Se(IV, VI) – in the range of 15–75 ng/l Se. The higher oxidation states of antimony and seleniumwere found as the predominant form in the studied surface waters.</jats:p>
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Intriguing minerals: lorandite, TlAsS2, a geochemical detector of solar neutrinos
(Springer Science and Business Media LLC, 2019-06-19)
Jovanovski, Gligor
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Boev, Blažo
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Stafilov, Trajče
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Boev, Ivan

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