Faculty of Natural Sciences and Mathematics

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Elicitation of Hypericum perforatum L. hairy root cultures with salicylic acid and jasmonic acid enhances the production of phenolic compounds and naphthodianthrones with biological activities
(Springer Science and Business Media LLC, 2025-02-17)
Gjureci, Bedri
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Simic, Sonja Gadzovska
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Lipoxygenase Inhibitory Activity and Prostate Cancer Cytotoxicity of In Situ- and In Vitro-Cultivated Balkan Endemic Sideritis scardica Griseb
(MDPI AG, 2025-10-25)
Danova, Kalina
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Stoyanova, Elena
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Alipieva, Kalina
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Sideritis scardica Griseb., a Balkan endemic species traditionally used for respiratory conditions and wound-healing, was investigated for its 15-lipoxygenase (15-LOX) inhibitory and cytotoxic activities in relation to its phenolic composition. Aerial parts from the wild-collected and in vitro-cultivated plant were successively extracted with hexane, chloroform, and methanol and the methanol extract was further fractionated into ethyl acetate, butanol, and water fractions. This study presents the first combined evaluation of LOX inhibition and cytotoxicity against prostate cell lines WPMY-1 (normal epithelial fibroblast/myofibroblast), PC-3 (epithelial adenocarcinoma, Grade IV), and LNCaP (epithelial carcinoma) and detailed phytochemical profiles of wild-collected and in vitro-cultivated S. scardica. The phytochemical analysis revealed distinct profiles: increased LOX-inhibition activity was related to a higher phenylethanoid/flavone glycoside ratio, while PC cytotoxicity was rather related to flavone glycoside domination in the plant preparations. The cytotoxic effect of the in vitro-obtained preparations was characterized by a marked selectivity when comparing their effects on WPMY-1, PC-3 and LNCaP cells. To our knowledge, this is the first report linking phenylethanoid/flavone glycoside profiles of in situ and in vitro S. scardica plants with dual LOX-inhibitory and anti-prostate cancer activities, supporting the plant’s potential as a sustainable source of bioactive compounds.
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Exploring natural indicators: aronia berries and turmeric as eco-friendly and cost-effective alternatives for acid–base titrations
(Springer Science and Business Media LLC, 2025-04-25)
Sofronievska, Ivona
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Semi-Quantitative Characterization of Volatile Organic Compounds in Indoor and Outdoor Air Using Passive Samplers: A Case Study of Milan, Italy
(MDPI AG, 2025-09-16)
Mula, Vllaznim
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Zeneli, Lulzim
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Mehmeti, Valbonë
This study presents a semi-quantitative characterization of volatile organic compound (VOC) concentrations and their emission sources in indoor and outdoor environments across four residential and laboratory sites in Milan, Italy, during the summer of 2024. Radiello® passive samplers (Fondazione Salvatore Maugeri in Padova, Italy) were employed for VOC collection, followed by gas chromatography–mass spectrometry analysis. The semi-quantitative mean total VOC (TVOC) concentration was 220.8 ± 195.4 µg/m3 for the outdoor air and slightly higher at 243.6 ± 134.3 µg/m3 for the indoor air, resulting in an indoor-to-outdoor relative ratio of 1.10. The outdoor VOC profile was dominated by hydrocarbons, accounting for 80.3% ± 4.6% (173.2 ± 143.8 µg/m3) of TVOCs, followed by aromatic hydrocarbons at 13.3% ± 5.5% (37.2 ± 49.7 µg/m3). Indoors, hydrocarbons also predominated, representing 34.1% ± 15.2% (95.2 ± 80.1 µg/m3) of the TVOCs, followed by terpenes at 20.7% ± 15.5% (49.0 ± 46.4 µg/m3). Other VOC groups contributed smaller fractions in both environments. The emission profiles from cleaning and personal care products were assessed semi-quantitatively to determine their relative percentage contributions to the indoor VOCs. Source attribution was further supported by diagnostic relative ratios—benzene/toluene, toluene/benzene, and (m + p)-xylene/ethylbenzene—which provided insight into dominant emission sources and photochemical aging.
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Effect of Jasmonic Acid on the Elicitation of Phenolic Compounds and Naphthodianthrones in Hypericum perforatum L. Callus and Shoot Cultures
(MDPI AG, 2025-10-08)
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Bozhinovska, Ana
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Dzambazovska, Stefana
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Gadzovska Simic, Sonja
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Passive sampling-based characterization of volatile organic compounds in Skopje: seasonal trends and source identification
(Springer Science and Business Media LLC, 2025-10-27)
Sofronievska, Ivona
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Sofronievski, Bojan
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Establishment, evaluation, and application of a gas chromatography–mass spectrometry method for quantification of volatile organic compounds in ambient air using anisole as an internal standard
(SHTM, UKIM, 2024)
Sofronievska, Ivona
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State of antioxidant systems and phenolic compounds’ production in Hypericum perforatum L. hairy roots
(Springer Science and Business Media LLC, 2019-07-09)
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Spasenoski, Mirko
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Gadzovska Simic, Sonja
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Determination of phenolic compounds in methanolic extracts of flowering stems and rosette leaves of Sideritis raeseri
(Macedonian Pharmaceutical Association, 2022)
Qazimi, Bujar
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Dragusha, Shpend
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Ejupi, Valon
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Comparison between Bulgarian and Macedonian propolis: chemical composition and plant origin
(Macedonian Pharmaceutical Association, 2020)
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Trusheva, Boryana
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Popova, Milena
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Antonova, Daniela
Propolis is used as a constituent in over-the-counter preparations, food additives, cosmetics, etc. Bulgarian and Macedonian propolis samples were analyzed by gas chromatography – mass spectrometry (GC-MS) of ethanol extracts after silylation, in order to determine the presence of bioactive substances with antimicrobial and antioxidant activity and their chemical profiles were compared. Bulgarian and Macedonian propolis demonstrate very similar chemical profiles and belong to the Poplar type propolis, which has well-characterized qualitative composition and high content of bioactive substances. These results allow the standardization of Macedonian propolis to be approached on the basis of the recommendations by the International Honey Commission for poplar propolis. Keywords: Bulgarian propolis, Macedonian propolis, GC-MS, chemical profiling</jats:p>

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