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EUTROPHICATION – A NEED FOR UNDERSTANDING THE DANGERS FROM AN OLD NEMESIS
(Macedonian Academy of Sciences and Arts, 2026-02-11)
S. Krstić, Svetislav
;
Aleksovski, Boris
Nutrient enrichment of aquatic environments, or eutrophication in modern terms, is a fundamental primordial planetary process that enables the proliferation of life in otherwise "sterile" ecosystems. It strongly supports the rapid expansion of primary producers, most of all – the algae, which initiates the formation of sequenced food chains, leading to life boosts in specific areas. This so-called ‘natural’ eutrophication has been a driving force for living forms throughout the history of our planet, and may even have been depicted in the Bible. However, the development of human society, including agriculture, industrial and technological expansion, and waste generation, has been the starting point of socalled ‘cultural’ or accelerated eutrophication that poses numerous problems for both the environment and humans. Based on selected natural and manmade ecosystems in North Macedonia, this paper points out the necessity of understanding and combating the deleterious effect of accelerated eutrophication in all water bodies.
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Expanding species diversity in the monotypic genera Thalassoporum and Tumidithrix (Pseudanabaenales, Cyanobacteriota) with the description of Thalassoporum mexicanum sp. nov. and Tumidithrix helvetica sp. nov.
(Microbiology Society, 2025-08-19)
Saraf, Aniket
;
Aleksovski, Boris
;
Blondet, Eddy
;
Krstić, Svetislav
;
Criscuolo, Alexis
The taxonomic identity of two well-documented pseudanabaenalean strains, Pseudanabaena sp. PCC 7367T and Pseudanabaena sp. PCC 7403T, isolated from the samples collected from the surface of a snail shell in an intertidal zone and sphagnum bog, respectively, was reassessed using a polyphasic approach. The results from the morphological, phylogenetic, ITS rRNA and genomic analyses confirmed that PCC 7367T (=BACA0810T) and PCC 7403T (=BACA0811T) represent novel species of the monotypic pseudanabaenalean genera Thalassoporum and Tumidithrix, respectively, for which we propose the names Thalassoporum mexicanum sp. nov. and Tumidithrix helvetica sp. nov. in accordance with the International Code of Nomenclature of Prokaryotes. The analysis of the 16S-23S ITS rRNA region, a widely used genetic marker for the delineation of closely related species, effectively distinguished the Thalassoporum species. However, the closely related species within Tumidithrix could not be demarcated using the currently accepted nucleotide dissimilarity cutoff for species delineation but were clearly distinguished through genomic analyses. Accordingly, a revised ITS rRNA nucleotide dissimilarity cutoff is proposed for species delineation within the genus Tumidithrix. Furthermore, genomic investigations revealed that the predicted biosynthetic gene clusters in the genome assemblies of PCC 7367T and PCC 7403T were not associated with any known natural products.
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Inflammatory and oxidative stress markers in intracerebral hemorrhage: Relevance as prognostic markers for quantification of the edema volume
(2023-03)
Rendevski, Vladimir
;
Aleksovski, Boris
;
Mihajlovska Rendevska, Ana
;
Hadzi-Petrushev, Nikola
;
We aimed to analyze the inflammatory and oxidative stress (OS) markers after intracerebral hemorrhage (ICH) and their temporal changes, interaction effects, and prognostic values as biomarkers for the prediction of the edema volume. Our prospective, longitudinal study included a cohort group of 73 conservatively treated patients with ICH, without hematoma expansion or intraventricular bleeding, which were initialized with the same treatment and provided with the same in-hospital care during the disease course. Study procedures included multilevel comprehensive analyses of clinical and neuroimaging data, aligned with the exploration of 19 inflammatory and five OS markers. White blood cells (WBC), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), neutrophilia, and lymphopenia peaked 3 days post-ICH, and they showed much stronger correlations with clinical and neuroimaging variables, when compared to the admission values. An intricate interplay among inflammatory (WBC, CRP, neutrophils, neutrophil-to-lymphocyte ratio [NLR], interleukin (IL)-6, and IL-10) and OS mechanisms (catalase activity and advanced oxidation protein products [AOPP]) was detected operating 3-days post-ICH, being assessed as relevant for prediction of the edema. The overall results suggested complex pathology of formation of post-ICH edema, via: (A) Not additive, but statistically significant synergistic interactions between CRP-ESR, neutrophils-CRP, and neutrophils-IL-6 as drivers for the edema formation; (B) Significant antagonistic effect of high protein oxidation on the CRP-edema dependence, suggesting a mechanism of potential OS-CRP negative feedback loop and redox inactivation of CRP. The final multiple regression model separated the third-day variables NLR, CRP × AOPP, and WBC, as significant prognostic biomarkers for the prediction of the edema volume, with NLR being associated with the highest effect size. Our developed mathematical equation with 3D modeling for prediction and quantification of the edema volume might be beneficial for taking timely adequate strategies for prevention of delayed neurological deteriorations.

Institute of Biology

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