Faculty of Pharmacy
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Item type:Publication, Critical development by design of a rugged HPLC-MS/MS method for direct determination of ibuprofen enantiomers in human plasma(Elsevier BV, 2015-06); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, CHEMOMETRIC APPROACH FOR OPTIMIZATION OF HILIC METHOD FOR SIMULTANEOUS DETERMINATION OF IMIPENEM AND CILASTATIN SODIUM IN POWDER FOR INJECTION(Informa UK Limited, 2013-12-11); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, High-Throughput HPLC-MS/MS Method for Quantification of Ibuprofen Enantiomers in Human Plasma: Focus on Investigation of Metabolite Interference(Oxford University Press (OUP), 2016-10-12); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Transformation model to green HPLC methods for lipophilic acidic compounds based on isoeluotropic series of elution solvents(Elsevier BV, 2025-06) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Characterization of physicochemical properties of substances using chromatographic separation methods(Macedonian Pharmaceutical Association, 2020-10-29); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Green RP-HPLC methods for assay and related substances in rivaroxaban tablets(Akademiai Kiado Zrt., 2023-11-29); ; ; <jats:title>Abstract</jats:title><jats:p>In this study, two different ethanol-based RP-HPLC methods for assay and quantification of rivaroxaban related substances in tablets were developed, based on green analytical chemistry (GAC) principles, using the design of experiments approach. The chromatographic separation was performed on X-Bridge C18 column (250 × 4.6 mm, 5 µm particle size), using isocratic elution with ethanol : water (35:65, % <jats:italic>v/v</jats:italic>) for the assay and gradient elution with ethanol/water mobile phase, for related substances, with a flow rate of 1.0 mL min<jats:sup>−1</jats:sup>. The gradient method was optimized for the separation of three specified impurities (impurity G, impurity H, and impurity 14) and the selectivity was further confirmed using forced degradation studies. Both methods were validated in accordance with ICH guidelines. The robustness of the methods was confirmed with the Central Composite Face Design of Experiments. Analytical Eco-scale approach and AGREE metrics confirmed that both methods are in accordance with the GAC principles. The proposed ethanol-based RP-HPLC methods were applied for assay and determination of related substances in rivaroxaban 10 mg tablets obtained from three different manufacturers available on the Macedonian market.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Design of experiments (DoE) to model phenolic compounds recovery from grape pomace using ultrasounds(Springer Science and Business Media LLC, 2021-11-22) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Headspace screening: A novel approach for fast quality assessment of the essential oil from culinary sage(Elsevier BV, 2016-07); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Optimization of ion-suppression reverse phase-separation of basic compounds using different mobile phases(Macedonian Pharmaceutical Association, 2022-12-31); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Possibilities and challenges of "green" chromatographic solutions(Macedonian Pharmaceutical Association, 2022-12-31); ; ; ;