Faculty of Medicine
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Item type:Publication, IMPACT OF TIME-TO-TREATMENT AND THROMBECTOMY TECHNIQUE ON OUTCOMESINACUTEISCHEMICSTROKE:ASINGLE-CENTERCOHORTANALYSIS(Macedonian Association of Anatomists and Morphologists, 2025-06); ; ; ; Introduction:Mechanical thrombectomy (MT) is the standard of care for acute ischemic stroke (AIS) secondary to large vessel occlusion (LVO). Time-to-reperfusion is the most critical determinant of patient outcome. This study aimed to conduct a comprehensive analysis of key time metrics and the efficacy of MT at our institution, evaluating their impact on both angiographic and clinical results to identify areas for process optimization.Methods:We conducted a retrospective analysis of a cohort of 17 consecutive patients treated with MT for LVO stroke. We analyzed demographics, baseline clinical status (mRS), occlusion location, detailed time-to-treatment intervals, procedural techniques, and outcomes. The primary angiographic endpoint was successful reperfusion, defined as an extended Thrombolysis in Cerebral Infarction (eTICI) score of ≥2b. Clinical endpoints included functional outcome at 3 months, measured by the mRS, and the rate of symptomatic intracranial hemorrhage (sICH).Results:The mean patient age was 60.9 years, with a significant male predominance (70.6%). All patients presented with severe stroke (initial mRS 4-5), indicating a high-acuity cohort. The mean time from symptom onset to final reperfusion was prolonged at 505 minutes (8 hours 25 minutes). Despite this, a high rate of successful reperfusion (eTICI ≥2b) was achieved in 85.7% of patients, with complete reperfusion (eTICI ≥2c/3) in 57.1%. However, this technical success did not fully translate to clinical recovery, as a good functional outcome (mRS 0-2) at 3 months was achieved in only 30.8% of patients. The rate of sICH was 15.4%.Conclusion:Our center achieves high rates of technical success in reperfusion (85.7% eTICI ≥2b), comparable to international benchmarks. However, prolonged treatment delays are significantly attenuating clinical outcomes, with only 30.8% of patients achieving functional independence. This analysis underscores that procedural excellence alone is insufficient; optimizing system-wide time-to-treatment protocols isthe critical next step to improve patient recovery. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Gender difference in the treatment outcome of patients served in the mixed-gender program(Comenius University, Faculty of Medicine, Bratislava, Slovakia, 2009); Raleva, M.The aim of the study was to determine whether the treatment outcome differs for males and females in the mixed-gender methadone maintenance program. A prospective non-randomized study was performed to evaluate the efficiency of the treatment over a period of 6 months. In this study, 91 patients (60 male and 31 female) were included and the groups were compared by the variables such as relapses, frequency of relapses, type of substance used and the manner of drug use. The results showed that 16 (51.6%) female addicts had 147 relapses and 23 (38.3%) male addicts had 118 relapses, but these differences were statistically not significant. Women made a significant relapse 43.7% more than men 21.7%, with heroine alone. The injectable drug abuse dominates in both genders, i.e. 56.2% of female examinees and 69.6% of male examinees injected the drugs, but this difference was not statistically proven. Conclusion: Gender has an influence on the response to the treatment. The outcome of the treatment measured through the drug use differs in the substance used. Women use more heroine than men, who in turn use more combinations of different drugs and legal psychoactive substances during the treatment