Faculty of Medicine
Permanent URI for this communityhttps://repository.ukim.mk/handle/20.500.12188/14
Browse
3 results
Search Results
- Some of the metrics are blocked by yourconsent settings
Item type:Publication, Incidence and Prevalence of Vaginal Infections in Women of Reproductive Age in North Macedonia(Macedonian Academy of Sciences and Arts/Walter de Gruyter GmbH, 2023-07-01); In the available literature on this subject there are many studies which describe the effects of sexually transmitted infections on pregnancy and fertility of women. Because of the frequency of the infections with the atypical bacteria of the Ureaplasma Spp., Mycoplasma Spp., Chlamydia Trachomatis, as well as HPV infections in women of reproductive age, it is easy to underestimate their importance when establishing the basis of the genital health of women of reproductive age. In this prospective analysis, conducted from 2014 to 2018 in the laboratory for HPV and Molecular diagnostics at the University Clinic of Gynaecology and Obstetrics in Skopje, North Macedonia, we analysed the results of 10,387 patients of all ages, of which 973 patients were of reproductive age. A Panel analysis was also conducted (including the above-mentioned pathogens). An HPV analysis was also conducted on 643 patients in this group. Within the group of 643 patients, there was a positive result for HPV in 26.7% of them, while in 40.9% there was a positive result for one or more pathogens on the Panel analysis of bacterial pathogens. The statistical analysis of the results showed that the most frequent of all bacterial pathogens within the Macedonian population of women of reproductive age is Ureaplasma Spp, with an incidence of 33%, followed by Mycoplasma Spp., with 7.8%, while Chlamydia Trachomatis was present in 6.4% of the cases. We should highlight that a co-infection with HPV was present in 18.5% of all the patients where there was analysis of both diagnostic procedures. The analysis of the results in the patients co-infected with HPV and at least one bacterial pathogen on the Panel Analysis, showed a very high statistical correlation (p<001). - Some of the metrics are blocked by yourconsent settings
Item type:Publication, VAGINAL MICROBIOTA COMPOSITION PROFILES IN WOMEN AT DIFFERENT LIFE STAGES(Macedonian Association of Anatomists and Morphologists, 2024); ; ; The vaginal microbiome is a reproductive organ-specific association that harbors a unique collection of anaerobic and aerobic microorganisms. It plays a crucial role in woman`s reproductive wellbeing and prevention of urogenital diseases including bacterial vaginosis (BV), infections with opportunistic microorganisms, yeast infections, urinary tract infections and sexually transmitted diseases. The composition of the vaginal microbiota undergoes significant changes during different stages of women's life cycle and is influenced by variations in sex hormone levels, physiological factors (e.g. the menstrual cycle and pregnancy) and individual lifestyle choices. Evidence shows that these various factors can influence the vaginal microbiome, potentially leading to an imbalance in the microbial community and genital infections. The aim of the present study was to compare the composition of vaginal microbiota in women at different life stages. A total of 2032 vaginal and cervical swab samples from women at different age, submitted for routine testing at the Institute for microbiology and parasitology were analyzed. Vaginal microbiota was evaluated by means of quantitative PCR in real time (Femoflor Screen, DNA-Technology).The results showed a dominance of lactobacilli in majority of the samples from the first two groups young women and women in reproductive years (72% and 69%, respectively), whilst a decrease of normocenosis was noted in women over 45 years (47%). Moderate dysbiosis was detected in 18% of both 15-25 yrs and 25-45 yrs age groups compared to 21% of the women of the > 45 yrs group. Severe dysbiosis prevailed among women of the >45 yrs group (32%) compared to 13% and 10% in the 15-25 yrs and 25-45 yrs age groups, accordingly. The results from this study provide comprehensive picture of our current knowledge of the composition and abundance of the microbiota of the female reproductive tract during different life phases. The tremendous importance of the microbiome for the reproductive health imply a necessity of future studies focused on providing more detailed information its composition and susceptibility to external influences. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, SOCIOECONOMIC STATUS AND REPRODUCTIVE HEALTH OF MOTHERS FROM DIFFERENT ETHNIC GROUPS IN NORTH MACEDONIA(Институт за јавно здравје на Република Македонија = Institute of public health of Republic of Macedonia, Co-publisher Scientific foundation Spiroski, 2024-12-16)A reproductive health framework would provide a broader programmatic focus that could bring needed attention to such issues as sexually transmitted diseases, infertility, abortion and women‘s empowerment generally. In order to analyze the elements of the reproductive health of our population, a one-year study was conducted that included 400 women in labor. Material and methods: Age, parity, number of pregnancies and deliveries antepartal controls, supplements intake, place of residence, etc. were analyzed. A descriptive analysis and statistical significance were made providing women‘s ethnicity. The results showed that the highest average age of women giving birth was registered among Macedonian women and it was 31.5 ± 5.4 years, and the lowest among Roma women 22.9 ± 5.4 years. The highest average number of deliveries among women in labor was observed in Roma and Bosnian women and it was 2.4±1.2 deliveries, and the lowest rate in Serbian women 1.3±0.6. The difference was statistically significant. It can be concluded that the emancipation of women, the level of education and the employment of women among all ethnic groups are the most important factors in the urban region. The traditions of religion and ethnicity are fundamental in family planning and have the main influence on women‘s reproductive life.