Faculty of Medicine
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Item type:Publication, The Incidence of Lymphovascular and Perineural Invasion and their Impact on Survival in Patients with Rectal Cancer(Walter de Gruyter GmbH, 2023-12); Ulusoy, CemalAim: Lymphovascular Invasion (LVI) and Perineural Invasion (PNI) represent undesirable but still realistic pathological features of rectal cancer, associated with poor prognosis and worse survival. The aim of this study is to assess the incidence of LVI and PNI in patients treated for rectal cancer and the impact of LVI and PNI on patient survival. Material and Methods: This retrospective single center observational study, conducted in the period of 2016-2019, includes patients with rectal cancer treated with/without long-course neoadjuvant chemoradiotherapy (nCRT). Data collection encompassed demographics, tumor characteristics, type of surgery (abdominal perineal rectal resection - APR and low anterior rectal resection - LAR), and LVI/PNI presence. Survival during follow-up was estimated and compared for patients with/without LVI and PNI involvement. Results: A total number of 234 patients (77 females and 157 males) with mean age of 61.3 enrolled in the study. Neoadjuvant CRT was conducted in 170 patients. APR procedure was performed in 67 of them and LAR in 167. LVI presence was noted in 55 (24.4%) and PNI in 77 (34.2%) patients. Mean survival during follow-up was 42.07 months. The use of nCRT influenced on survival (p < 0.033). Patients treated with LAR had better survival outcomes (p = 0.001). Presence of LVI and PNI was associated with a worse prognosis (p < 0.001). Conclusion: PNI was more frequent than the LVI in this study. Patients with nCRT conduction had better overall survival. LVI and PNI presence was associated with poor prognosis in terms of overall survival in patients with rectal cancer. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Protective ileostomy in rectal cancer surgery - is it really temporary?(2023-03-27) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Determining the Efficiency of a Commercial Belly Board Device in Reducing Small Bowel Volume in Rectal Cancer Patients(Association for Medical Physics and Biomedical Engineering, 2010-11-06); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, THE VALIDITY OF MAGNETIC RESONANCE IMAGING IN DETERMINING PREOPERATIVE NODAL STAGING IN RECTAL CANCER(Македонско лекарско друштво = Macedonian Medical Association, 2020); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, THE VALIDITY OF MAGNETIC RESONANCE IMAGING IN DETERMINING PREOPERATIVE T STAGE OF RECTAL CANCER(Department of Anaesthesia and Reanimation, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, R. Macedonia, 2020-06); Valjon SaliuIntroduction: The significance of preoperative staging of rectal cancer with magnetic resonance imaging is initial for the decision on further treatment of the disease, simple surgical or multimodal treatment at an advanced stage of rectal cancer. Aim of the Study: This paper demonstrates the validity of magnetic resonance imaging in determining the T stage of rectal cancer preoperatively, in correlation to the findings from the operative pathohistological material. Material and Methods: 82 patients aged from 43 to 87 years, with previously colonoscopy proven rectal cancer were treated in magnetic resonance imaging (MRI) – 1.5 T, standard pulls sequences were made: SAG T2, AX T1, AX T2, AX DWI and T stages were determinated. Results: The results obtained for the T stage with magnetic resonance are correlated to the pathohistological finding taken postoperatively as the gold standard in determining the sensitivity and specificity of magnetic resonance imaging. The sensitivity of MRI in determining the rectal cancer at T1 and T2 stage carcinomas was 86.7% and the specificity was 98.5%. The sensitivity of MR in determining T3 stage rectal cancers was 89.1% and the specificity was 88.9%. The sensitivity of MR in determining the T4 stage rectal cancers was 91.7% and the specificity was 92.9%. Conclusion: Magnetic resonance imaging is the gold standard in preoperative staging of rectal cancer. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, IMPORTANCE OF EXTRAMURAL VASCULAR INVASION IN PREOPERATIVE STAGING OF RECTAL CANCER WITH MRI(Македонско лекарско друштво = Macedonian medical association, 2018-03-03); Introduction. Rectal cancer is the third most common malignant disease worldwide with a high mortality rate in developed countries. The prognosis of rectal cancer has been significantly improved over the past decade, and this is mainly due to progress in preoperative staging, which has been reflected in the therapeutic approach, where a significant change was made from simple surgical treatment to multimodal treatment. Although extramural vascular invasion (EMVI) is not included in the classical protocol for preoperative staging, itis a significant prognostic indicator of the recurrence rate. Methods. The study is a prospective one, and it included 61 hospital patients with previously proven rectal cancer, who had been operated on at the Department of Abdominal Surgery ofthe University Clinic for Surgical Diseases “St. Naum Ohridski” in Skopje, and who underwent a magnetic resonance staging preoperatively. Results. Comparison of extramural vascular invasion determined with MR preoperatively with pathohistological postoperatively obtained result. Conclusion. MR as an ideal imaging method in preoperative staging of rectal carcinoma. It is a tool that determines with high accuracy the extramural vascular invasion in patients with rectal cancer.