Faculty of Medicine

Permanent URI for this communityhttps://repository.ukim.mk/handle/20.500.12188/14

Browse

Settings

Subject: search.filters.subject.hypertensive disorders of pregnancy

Search Results

Now showing 1 - 2 of 2
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Placental abruption as the first manifestation of severe preeclampsia: A case report
    (APROFEMA, 2025-09-26)
    Kostovska, Irena
    ;
    Placental abruption is a potentially life-threatening obstetric complication, often associated with hypertensive disorders of pregnancy. While its occurrence in the context of preeclampsia is well-documented, it is uncommon for placental abruption to serve as the initial clinical manifestation. We report the case of a 23-year-old primigravida at 30 weeks of gestation who presented with abruptio placentae and was subsequently diagnosed with severe preeclampsia. Intraoperative findings revealed a Couvelaire uterus, a rare consequence of placental abruption characterized by extravasation of blood into the myometrium. Prompt cesarean delivery and conservative management resulted in favorable maternal and neonatal outcomes. This case underscores the importance of recognizing atypical presentations of hypertensive disorders during pregnancy and the critical role of timely intervention.
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    The Role of Endothelial Dysfunction in the Pathogenesis of Pregnancy-Related Pathological Conditions: A Review
    (Walter de Gruyter GmbH, 2023-07)
    ;
    ;
    ;
    Milivojevic, Vladimir
    ;
    Rankovic, Ivan
    In the recent decades, endothelial dysfunction (ED) has been recognized as a significant contributing factor in the pathogenesis of many pathological conditions. In interaction with atherosclerosis, hypercholesterolemia, and hypertension, ED plays a crucial role in the pathogenesis of coronary artery disease, chronic renal disease, and microvascular complications in diabetes mellitus. Although ED plays a significant role in the pathogenesis of several pregnancy-related disorders such as preeclampsia, HELLP syndrome, fetal growth restriction, and gestational diabetes mellitus, the exact pathogenetic mechanisms are still a matter of debate. The increased prevalence of these entities in patients with preexisting vascular diseases highlights the essential pathological role of the preexisting ED in these patients. The abnormal uteroplacental circulation and the release of soluble factors from the ischemic placenta into the maternal bloodstream are the main causes of the maternal ED underlying the characteristic preeclamptic phenotype. Besides the increased risk for maternal and fetal poor outcomes, the preexisting ED also increases the risk of development of future cardiovascular diseases in these patients. This study aimed to look deeper into the role of ED in the pathogenesis of several pregnancy-related hypertensive and liver diseases. Hopefully, it could contribute to improvement of the awareness, knowledge, and management of these conditions and also to the reduction of the adverse outcomes and additional long-term cardiovascular complications.