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    Early onset of dementia in stroke patients
    (2021)
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    Taravari, A
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    Ademi, B
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    Pharmacotherapy of agitation in dementia
    (Macedonian Psychiatric Association, 2019)
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    Snezana Pejkovska-Dimovska
    Although we tend to focus on the cognitive issues ,the behavior of individuals with dementia is often the main problem that leads to institutionalization. Clinical guidelines recommend nonpharmacological approaches as the first choice in the treatment of behavioral and psychological symptoms [1]. Acetylcholinesterase inhibitors (AChEI) are the first-line pharmacological option ,but challenging risky behaviors may persist despite their use. Antipsychotics are indicated in such cases, but there is very limited evidence to support the efficacy and safety of these medications for managing agitation in dementia[2]. Antipsychotics are prescribed most often for this indication and, at the same time, are related to the highest risk of adverse effects and increased mortality. Compared with the common population, lower doses should be used and titrated gradually. When choosing the medication, pharmacokinetic and pharmacodynamic interaction with AChEI and memantine used by majority of patients with dementia should be considered [3][4].
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    Our preliminary experience with SPECT 99m Tc-HMPAO brain perfusion scans in diagnosis of dementia
    (2015)
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    Crcareva, Biljana
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    Zdraveska-Kocova, Marina
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    Krsteska, Roza
    ABSTRACT Introduction: Dementia is a clinical syndrome caused by a spectrum of different etiopathogenetic disorders, such as neurodegenerative, infective, expansive or other morphological processes in the brain tissue. Several studies indicate the possibility of differential diagnosis of dementia according to the findings of brain SPECT study. Aim: The objective of the paper is to present our preliminary experiences with SPECT 99mTc-HMPAO brain perfusion scintigraphy in the diagnosis of dementia. Materials and methods: 99mTc-HMPAO SPECT brain perfusion was performed on 9 patients selected after detailed neuropsychiatric investigations conducted by specialist psychiatrist. Obtained images were reconstructed with commercial software Mediso Brain SP128 and the qualitative and semiquantitative analysis of the data was carried out. Results: We found hypoperfusion defects in all evaluated patients, in most cases unilateral hypoperfusion in the left hemisphere, respectively in 56% of evaluated patients and in six out of nine, respectively in 67%, hypoperfusion of the left temporal lobe. Most common finding was parietal hypoperfusion, found in 8 patients (89%) and left mesial temporal lobe hypoperfusion, detected in 6 patients (67%). Conclusion: Findings of all the evaluated patients showed indisputable defects in perfusion which in correlation with clinical criteria give useful guidance in diagnosis of dementia. We concluded that it is necessary to continue with the prospective study of larger number of patients and with multidisciplinary approach in order to obtain relevant conclusions with statistical significance.
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    Stroke and dementia
    (League against Epilepsy of Macedonia, 2016)
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    Chepreganovska-Changova, Tatjana
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    Taravari, Arben