Faculty of Medicine

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    CORRELATION BETWEEN TONSIL HYPERTROPHY AND ALLERGIC RHINITIS IN CHILDREN
    (Macedonian Association of Anatomists, 2020-12-25)
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    Dukovska, Vesna
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    Nikoloska, Sofija
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    To show whether there is a correlation between the tonsils hypertrophy and adenoid hypertrophy (AH) with allergic rhinitis in children in R. Macedonia. A total of 120 children (5.3 ± 1.2 years old)with tonsil hypertrophy, adenoid hypertrophy, persistent upper respiratory infections and consecutive nasal obstruction were examined, after their parents gave a verbal consent for their participation. Inclusion criteria were: frequent upper respiratory infections, angina, nasal congestion due to nasal obstruction caused by adenoid hypertrophy, frequent serous otitis due to adenoid hypertrophy and sleep apnea due to tonsil hypertrophy.The prevalence of allergic rhinitis (AR) was as follows: AR had 70% of children with concha nasal hypertrophy, 39.2% of children with tonsillar hypertrophy, and 78.3% of children with adenoid hypertrophy. Although in the group of children with adenoid hypertrophy, a more severe degree of nasal concha hypertrophy was registered in children with AR compared to children without AR, itwasstatistically not significant.Regarding children with adenoid hypertrophy (AH), the results showed that children with AR presented significantly different results for Parikh's scale (p = 0.0076). Obstruction of torus tubarius was more common in children with AR (86.8% vs. 61.2%), while these children had a finding of soft palate obstruction (9.4% vs.26.8%), and vomer obstruction (3.8% vs.11.9%) less often than children without AR.Our study found that almost half of the children with tonsillitis/adenoid hypertrophy hadAR. Grade 3 and 4 TH was present in third of the children.
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    Correlation of cervical length, fetal fibronectin, phIGFBP-1, and cytokines in spontaneous preterm birth up to 14 days from sampling
    (De Gryter, 2014-12)
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    Stefanovic, Milan
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    Abstract Objective: The aim of this study was to determine the relationship between sonographic cervical length, fetal fibronectin (fFN), phIGFBP-1 (actim partus test), cytokines (IL-6, IL-2R, and TNF- α ), and spontaneous preterm birth (SPTB) up to 14 days from sampling. Methods: Fifty-eight patients were recruited in a period of 6 months from September 2013 until March 2014 with symptoms or complaints suggestive of preterm labor. Consenting women were treated according to usual hospital protocol, with addition of vaginal swabs taken for fetal fibronectin, phIGFBP-1 (actim partus test) and cervical IL6, IL2R, and TNF- α . The outcome variable was occurrence of preterm delivery within 14 days from the day of hospital admission. Results: Thirty-six patients (62.07%) were delivered within 14 days from admission. Our results indicated that the cervical length significantly inversely correlates with the concentration of IL-6 in the CVF (Spearman ’ s coefficient R = – 0.382, P < 0.05). Cervical length also correlated with a positive phIGFBP-1 test, i.e., patients with a positive test had an average cervical length of 18.5 ± 4.63 mm, which is significantly lower than patients with a negative test – 23.43 ± 7.39 mm (P = 0.003). Conclusions: The studied biochemical markers were only moderately successful in the prediction of preterm delivery.
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    Correlation of the system of cytokines in moderate and severe preeclampsia
    (IMR Press, 2016-01)
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    M. Hadži-Lega
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    M. Stefanovic
    Objective of the study: To study the production of pro-inflammatory (IL-1β, IL- 2, IL-6, IL-8) and anti-inflammatory (IL-4, IL-10) cytokines in pregnancy complicated by preeclampsia in the third trimester. Institution: University Clinic of Gynecology and Obstetrics, Skopje, Republic of Macedonia. Material and Methods: Fifty women with pregnancies complicated by preeclampsia in the third trimester and 50 women with physiological pregnancy. Levels of IL-1β, IL- 2, IL-6, IL- 8, IL- 4, and IL- 10 were measured by using a solid -phase enzyme immunoassay. Statistical data processing was done using the application program SPSS for Windows 13, 0. To describe the distribution of analyzed variables, descriptive methods (mean, median, minim and max) were used . Results: In pregnancies complicated by preeclampsia, there are increased levels of proinflammatory cytokines and a change in the behaviour of opposing pools. Most pronounced changes in the levels of proinflammatory cytokines were observed in mild preeclampsia. In severe preeclampsia there was reduction of the concentration of anti-inflammatory cytokines IL- 4 and IL-10. Conclusion: The use of assessment cytokine profile monitoring of health status of women with preeclampsia is expedient.
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    Correlation of the system of cytokines in moderate and severe preeclampsia
    (IMR Press, 2016-01)
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    Milan Stefanovic
    Objective of the study: To study the production of pro-inflammatory (IL-1β, IL- 2, IL-6, IL-8) and anti-inflammatory (IL-4, IL-10) cytokines in pregnancy complicated by preeclampsia in the third trimester. Institution: University Clinic of Gynecology and Obstetrics, Skopje, Republic of Macedonia. Material and Methods: Fifty women with pregnancies complicated by preeclampsia in the third trimester and 50 women with physiological pregnancy. Levels of IL-1β, IL- 2, IL-6, IL- 8, IL- 4, and IL- 10 were measured by using a solid -phase enzyme immunoassay. Statistical data processing was done using the application program SPSS for Windows 13, 0. To describe the distribution of analyzed variables, descriptive methods (mean, median, minim and max) were used . Results: In pregnancies complicated by preeclampsia, there are increased levels of proinflammatory cytokines and a change in the behaviour of opposing pools. Most pronounced changes in the levels of proinflammatory cytokines were observed in mild preeclampsia. In severe preeclampsia there was reduction of the concentration of anti-inflammatory cytokines IL- 4 and IL-10. Conclusion: The use of assessment cytokine profile monitoring of health status of women with preeclampsia is expedient.
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    Cysteinyl leukotrienes and hematoma-correlation study
    (League against Epilepsy of Macedonia, 2016)
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    Nikodijevic, Dijana
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    Baneva, Emilija