Faculty of Medicine

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    Perinatal complications and their association with maternal hypothyroidism
    (Bulgarian Association of Young Surgeons (ScopeMed), 2022-05)
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    Paneva, Iva
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    Introduction. Hypothyroidism in pregnant patients is more often associated with pregnancy complications. It increases the risk of obesity, diabetes, and hypertensive disorders, and has an impact on perinatal outcomes. There is a greater risk of congenital hypothyroidism or so-called cretinism, manifested by growth restriction, mental retardation and other neurophysiological defects. Iodine supplementation and proper administration of thyroxine preparations in the first and second trimesters significantly reduce neurological abnormalities. Purpose. Evaluation of pregnancies in patients with hypothyroidism and its impact on perinatal complications. Material and methods. The patients with hypothyroidism were analyzed from the total deliveries at the University Clinic for Gynecology and Obstetrics in Skopje. Patients are divided into two study groups: study and control groups. The study group includes patients with hypothyroidism. The control group includes patients without hypothyroidism. Results. The likelihood of obesity was assessed, and during the third trimester, the likelihood of developing diabetes, gestational hypertension, and preeclampsia as a single risk, was compared between the two groups. Patients with hypothyroidism are 3.49 times more likely to have obesity and 5.57 times higher risk of developing diabetes in pregnancy than those without hypothyroidism. The relative risk of developing gestational hypertension is 3.1 and OR 3.22 in patients with hypothyroidism, which means that 3.22 times more likely to develop gestational hypertension in this group. Preeclampsia develops in 2 patients (3.33%) with a relative risk of 2.07 and OR 2.11, or 2.11 times higher risk of developing preeclampsia in the hypothyroidism group. Conclusion. Early detection of thyroid disorders in a pregnant patient as well as in newborns postpartum allows for proper treatment of both mother and child, while uncontrolled hypothyroidism leads to adverse pregnancy outcomes and has fatal consequences.
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    BLEPHAROPLASTY - OUR EXPERIENCE
    (Македонско лекарско друштво = Macedonian medical association/De Gruyter, 2021)
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    One of the most popular aesthetic surgery procedures is blepharoplasty. Preoperative planning and tissue resection can reduce complications and improve outcomes. Although some patients want blepharoplasty to address age-related changes in the skin of their eyelids, the procedure is more of a sculpture and contouring of the overall aesthetic unit. In this paper we present the history, basic anatomy, indications and surgical technique of upper and lower blepharoplasty. The importance of the preoperative patient evaluation for blepharoplasty has also been stated. We present our experience in blepharoplasty surgery done at the University Clinic for Plastic and Reconstructive Surgery in a three-year period, along with the complication rate and outcome. We have briefly described the techniques of standard upper and lower eyelid blepharoplasty. Practically, the rejuvenation of this complex anatomical area requires a combination of therapies including fat excision, repositioning or transfer, simultaneous brow or midface lift, and adjunctive treatment for skin resurfacing and periorbital hollows.
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    Role of education in prevention and delay of complications in type 2 diabetic patients
    (bioscientifica, 2012)
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    Lumani, Sedat
    Aim: To assess the impact of education of people with T2DM and complications. Patients and methods. Observational study, 100 T2DM patients of age 35–75 years, both sex, duration of DM >1 year.Results. From 100 T2DM 47% were male sex and 53% female. Mean age 60.45±8y, duration of DM 10.45y±3 y. Average A1c 8%±0.6, BMI 27%, systolic BP 140±6 mmHg, TG 2.2±0.3 mmol/L, LDL 4.0±0.6 mmol/L. Education (diet, physical activities, drug compliance) for DM was 67% for male and 54% for female. Education for diabetic foot care (inspection, foot hygiene, appropriate shoes) 51% for male and 49% for female. Conclusion: Metabolic risk factors are poorer in no educated than in educated T2DM, People who had not satisfactory education for foot care have higher risk for foot ulceration.
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    Clinical Characteristics, risk factors and outcome in patients with in tracerebral haemorrhage
    (Leage against epilepsy of Macedonia, 2015)
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    Mitrevska Velkova Jasmina
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    Babunovska Marija
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    AbstractIntracerebral haemorrhage is a meaningful factors in the neurological praxis, as an urgent condition that requires timely detection and treatment with the purpose of improving trhe outcome. the aim of the study is to examine the clinical characteristics, risk factors and the outcome in patients with intacerebral haemorrhage. At the Department of urgent neurology of the University clinic of neurology in Skopje, Macedonia, a retrospective study was performed, with which 177 patients with intracerebralk heamorrhage, hospitalized at th University clinic of neurology within a two year period, are encompassed. the Main characteristics of the clinical features, risk factors, intrahospital complications and patient outcome werw researched. The results point to a nesessity of increased control of the risk factors with the patients, the effect of witch would be subject to futher studies.
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    Complications associated with acute pulmonary embolism – data from the registry of patients with venous thrombembolism
    (Македонско лекарско друштво = Macedonian Medical Association, 2022)
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    Dejan Todevski
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    Suzana Arbutina
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    Correct estimation of the severity, mortality, and complication risk are crucial for effective treatment of pulmonary embolism (PE). A total of 162 patients hospitalized with acute PE, treated either with standard treatment with heparin and vitamin K antagonists (VKA) or heparins, followed by direct oral anticoagulants (DOAC) were followed for a 90-days period. Demography, clinical and radiologic presentation, smoking status and concomitant comorbidities were analyzed. The mortality risk was estimated by calculating PESI and sPESI score. The results showed uneven utilization of both treatment modalities (93.8% treated with VKA versus 6.17% with DOAC). Smoking as an independent factor was detected in 55.56% of patients, and is greater than the overall smoking prevalence in Macedonia. Central propagation of PE was found in 57.79% of cases and together with the presence of pleural effusion was associated with a greater risk for complications. Estimation of 30-day mortality risk with PESI and sPESI showed their high predictive value, with an advantage of sPESI, in terms of better accuracy and simplicity of performance. Correct estimation of risk for complications and mortality is important for improving the overall safety of patients with PE and has a positive „cost-benefit“ effect for organization of the treatment.
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    EVALUATION OF RESPIRATORY FAILURE FOLLOWING PEDIATRIC CARDIAC SURGERY
    (Macedonian Association of Anatomists and Morphologists, 2021-08)
    Background: This study evaluated the respiratory failure (postoperative reintubation, respiratory acidosis, deterioration of gas blood, respiratory disfunctions, hypoxia) after congenital heart surgery. Material and methods: To evaluate the impact of respiratory failure (within 48 hours postoperatively) in patients undergoing congenital heart surgery. This retrospective study included 45 operated patients (male and female aged 3 to 9 months) who had undergone cardiac surgery at the University Clinic for Pediatric Surgery in a period of two years. Type of congenital heart diseases, perioperative and postoperative parameters (duration of cardiopulmonary bypass - CPB, cross-clamping of aorta, duration of stay in ICU and complications) were analyzed. Results: Of a total of 45 operated patients, five required reintubation, and their average age was 7.5 months, and median body weight 7.8 kg. Perioperative procedures were prolonged (duration of CPB - 97 minutes, aortic cross-clamping time - 59 min. and duration stay in ICU -7.2 days), caused postoperative complications (chylothorax, respiratory infection and thoracic bleeding) and worsening of respiratory failure. We evaluated postoperative respiratory failure in five reintubated patients. Conclusion: Prolongated perioperative and postoperative procedures were significantly associated with postoperative complications, worsening of the general condition and prolonged postoperative treatment.
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    Impact of socioeconomic status on the occurrence of complications after cochlear implantation - A case study
    (Institute of Sensory Organs, 1 Mokra Street, Kajetany, 05-830 Nadarzyn, Poland, 2018-06-27)
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    INTRODUCTION Cochlear implantation is a powerful tool for helping children with severe to profound sensorineural hearing loss gain the ability to hear, achieve age-appropriate reading skills, and develop communication skills equal to those of their hearing counterparts. Although it’s a reliable and safe procedure cochlear implantation surgery, like any other surgical procedures, has some minor and major complications. Major complications are those that are require surgery whereas minor complications are those that can be medically treated. The overall rate of complications among cochlear implant patients ranges from 6% do 20%. According to the time of appearance can be classified as immediate (< 1 week) or delayed (≥1 week) events. One of the quite worrying and potentially devastating are the postoperative wound infections after cochlear implantation. Because of the risk of the implant infection in this cases, which can lead to device removal with loss of the implant function, every effort must be made to prevent this infections, or if they occur to be timely and appropriately treated which will enable salvage of the implant and its function. AIM Тo emphasize the importance of socioeconomic status as risk factors for the occurrence of postoperative wound infection after cochlear impantation. MATERIALS AND METHODS We report the case of 4-year-old child with delayed postoperative surgical wound infection. The one appeared 14 days after the cochlear implantation (postoperatively). Anamnestic data obtained from the mother indicates that after discharging from the hospital the child was repeatedly itchy the wound. On examination a half of the surgical wound was reddish with mild discharge and starting dehiscence at one point. The swab obtained from the wound was positive for Vancomycin resistant-Enterococcus faecium. RESULTS An outpatient medical care with antiseptic dressing, topical and oral antibiotics was started immediately. Because of no response, even worsening of the local status, 7 days after a revision surgery was required. With the employment of timely and appropriate intraoperative wound debridement and re-suture the healthy edges without using a flap, the implant was salvaged. DISCUSSION/CONCLUSIONS As reported in the literature, in children from families with lower socioeconomic background incidence of complications is higher comparing to the children that come from families with higher income level. The reason for this can be poor hygienic conditions and habits, as well as negligent care of the parents. Тhis case is just another(one more) confirmation that the socioeconomic status can represents a possible risk factor for the occurrence of postoperative complications in children after CI surgery. Specially in an environment where because of financial barriers, access to the cochlear implantation is limited, special attention should be paid to the socioeconomic status of the candidates for CI. This indicates that a special approach in pre-operative preparation and postoperative care in the candidates for cochlear implantation with lower socio-economic back-ground is needed. Involvement of a motivated social workers in the care of the cochlear implant children is necessary for additional support and education if this group of parents and children, in order to prevent and reduce the negative impact of the socioeconomic background of the CI surgery outcomes.
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    THE PREDICTIVE VALUE OF SERUM LACTATE ON THE OUTCOME AFTER MAJOR ABDOMINAL SURGERY
    (Department of Anaesthesia and Reanimation, Faculty of Medicine, “Ss. Cyril and Methodius” University in Skopje, R.N.Macedonia, 2019-05)
    Angjushev D
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    Kotevska Angjushev M
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    Prevalence of Rotaviruses in the Etiology of Acute Diarrhea in Young Children, Clinical forms, Extraintestinal Manifestations and Complications
    (Macedonian Academy of Sciences and Arts/Sciendo, 2020-12-08)
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    Rotavirus is highly contagious factor with dominant feces-oral transmission. Because it is stable in external environment, transmission clusters are possible by close contact, ingestion of contaminated water or food or contact with contaminated surfaces. It survives within hours and days on hands and contaminated surfaces. This makes it the most common enteric and nosocomial pathogen in the world, especially in early childhood. In addition to the rapid dehydration with pronounced electrolyte disturbances, numerous extraintestinal possibilities have been recorded in the clinical picture, which emphasizes the need for prevention of this disease.In the period from 1.02.2018 to 31.01.2020 at the Clinic for Infectious diseases were treated 1060 patients with diarrheal disease, of which 502 children (47.36%). Rotavirus etiology was confirmed in 23.30% of the children. According to the protocols, laboratory and biochemical investigations were done to all 117 children, with tracking parameters and their dynamics of admission and discharge from the hospital. Most of the children, 84 (82.0 6%) are from urban areas, with a more confirmed epidemiological survey of 59 (42.00%). The average age of the children was 8 months, with a small percentage of children on maternal food (breastfed 25, i.e. 21.37%), with high febrile admission in 99% of children with an average temperature of 38.5oC and an average febrile duration of 4 days, with an average of 7 (+ 2.49) of stools and 5 (+ 2.12) of vomiting. There was a significant difference in hematocrit, leukocyte, electrolyte, glycaemia, and CRP values on admission and discharge. There was predominant isonatremic dehydration, and the compensatory mechanisms followed by the values of the electrolytes ABS, Ph, BE showed a tendency to maintain within the physiological limits. The clinical picture of extraintestinal manifestations included bronchitis, mesenteric lymphadenitis, upper respiratory infections and rash.Rotavirus infection is a serious health and economic problem in our country, so it needs continuous prevention and monitoring in order to reduce the incidence, and thus the need for hospitalization and cure of rotavirus disease.
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    The Impact of Pneumonia on the Course and Outcome in Patients with Seasonal Influzenza
    (Macedonian Academy of Sciences and Arts/Sciendo, 2020-09-01)
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    Introduction: Seasonal influenza, although often presented as a mild, self-limiting disease, is frequently accompanied by complications that lead to the development of a severe clinical presentation and a fatal outcome. The most common are respiratory complications, with secondary bacterial pneumonia being the leading cause. Aim: The aim of this study is to determine the impact of pneumonia on the severity of the clinical presentation and outcome in patients with seasonal influenza. Materials and methods: This research is comparatively group-based and has been conducted at the University Clinic for Infectious Diseases and Febrile Conditions during a three-year period. The analysis consists of 122 adult patients with clinically and laboratory-confirmed influenza. Based on the severity of the clinical picture, the patients are divided into two groups, severe (n=87) and mild (n=35) forms of the disease. The study included demographic, general data, clinical symptoms, and signs as well as complications. Results: Of 122 patients with seasonal influenza, complications were registered among 108(88.52%), with a significantly more frequent emergence among the group with severe influenza 93.1% vs 77.14% (p=0.012). Pneumonia was the most common 98(80.33%) and had a significant effect on disease severity (p=0.002). Complications from the types of ABI 8(6.56%), ARDS 7(5.74%), sepsis 5(4.1%), DIC 4 (3.28%) and otitis 2(1.64%) were reported only in the group with severe influenza. Acute meningoencephalitis was registered among 5(4.1%), gastroenterocolitis among 3(2.46%), and hepatic damage among 14(11.47%) of patients. Conclusion: Pneumonia as the most common complication among patients with seasonal influenza significantly impacts the clinical course and outcome of the illness.