Faculty of Medicine
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Item type:Publication, METABOLIC VARIATIONS AMONG WOMEN WITH POLYCISTIC OVARY SYNDROME ACCORDING TO BODY MASS INDEX(Македонско лекарско друштво = Macedonian medical association, 2025-12); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, THE ROLE OF OBESITY AS NONOCCUPATIONAL RISK FACTOR IN PATIENTS WIT CARPAL TUNNEL SYNDROME(Macedonian Association of Physiologists and Anthropologists, 2020); ; ; Zaevska, Zorica - Some of the metrics are blocked by yourconsent settings
Item type:Publication, THE IMPACT OF OBESITY AND FAT DISTRIBUTION ON ENDOMETRIAL CANCER RISK IN POSTMENOPAUSAL PATIENTS(Macedonian Association of Anatomists, 2023); ; ; ; Endometrial cancer (EC) is the fourth most common cancer in women worldwide, with rising incidence partly due to changing reproductive trends and ever increasing obesity. Obesity, especially central adiposity, is linked with endometrial adenocarcinoma, possibly due to elevated estrogen and decreased sex hormone-binding globulin levels. The study aims to evaluate the impact of obesity on endometrial malignancy and to determine whether central adiposity (measured by the waist-to-hip circumference ratio) serves as a better indicator of endometrial cancer risk than BMI. In this cross-sectional study, we studied 164 postmenopausal patients from the University Clinic of Obstetrics and Gynaecology in Skopje. Patients were admitted to the hospital for histopathological examination of endometrial layer because of vaginal bleeding with endometrial thickness >4mm, or other sonographic endometrial abnormalities. Histopathological findings subdivided them into two categories: with malignancy (group I) or benign abnormality (group II). Standard examinations and measurements, including BMI and waist-to-hip ratio, were performed. A significant association was observed between endometrial malignancy and obesity as measured by waist-to-hip ratio. In the distribution of data related to BMI and histopathological findings from the endometrial biopsy for Pearson Chi-square=8.35 and p<0.01(p=0.004) there is a significant difference. For Odds Ratio=2.71 (95.%CI:1.36-5.38), patients who had a BMI ≥ 30 kg/m2 were 2.71 times more likely to have endometrial malignancy than patients who had a BMI <30 kg/m2, (p<0.01). There is a significant difference in the shown distribution of data related to waist circumference/hip circumference and histopathological findings of endometrial sampling Pearson Chi-square=79.22 and p<0.001(p=0.000). For Odds Ratio=40.89 (95.% CI:15.23-109.78), patients who had waist circumference/hip circumference ≥ 0.85 were 40.89 times more likely to have endometrial malignancy than patients who had waist circumference/hip circumference <0.85, (p<0.001). Upon analysing the contribution of central obesity determined by waist-to-hip ratio, it was found to have a more substantial impact (Wald = 37.76, p < 0.001) compared to BMI (Wald = 0.97, p= 0,32). Our study confirms that obesity is a risk factor for endometrial malignancy. Furthermore, fat distribution proves to be a more crucial and accurate indicator of endometrial cancer risk than overall obesity. The statistical significance of the waist circumference to hip circumference ratio exceeded that of BMI. Therefore, even if a patient has a normal BMI, but a waist-to-hip circumference ratio greater than 0,80, she should be considered at increased risk for endometrial malignancy and should be closely monitored in the future in order to detect any malignant changes. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, BODY COMPOSITION RELATED TO BODY MASS INDEX AMONG YOUNG ELITE FOOTBALL PLAYERS(Medical faculty, Ss Cyril and Methodius University in Skopje, 2017); ; ; ; Abstract Introduction. Body composition is extremely important for athletes’ performance, thus assessment tools may be used to clarify their sports condition. The aim of the study was to investigate body composition measurements and maximal oxygen consumption related to body mass index (BMI) in young elite football players. Material and methods. A total of 29 young football players were divided into 3 groups related to the value of BMI: I group (n=8); II group (n=13); and III group (n=8). The subjects were submitted to the sub-maximal pulse approach on treadmill method (SchillerAg, MTM-1500 Bear, Switzerland) to measure VO 2max (ml/kg/min). A body composition analyzer (InBody720, Biospace Co, Seoul, Korea) was used to determine the body fat - BF (%), skeletal muscle - SM (%) and total body water – TW(L) including intracellular body water – ICW(L) and extracellular body water – ECW(L). For the statistical analysis, a t-test was performed upon which the significance for p<0.05 was considered. Results. The football players showed the highest VO 2 max value in the II group (p<0.05). BF showed increased value in the III group (p<0.02). SM did not show any significant difference between the groups. Body water composition showed no statistical significance. Conclusion. Due to our results, we may conclude that certain parameters may determine the condition of young athletes in order to select appropriate training procedures, proper diet, and personalized performance. Key words: football; body mass index; body composition. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, OBESITY PARAMETERS IN FEMALE MEDICAL STUDENTS(Faculty of Medicine, University Ss. Cyril and Methodius in Skopje, 2021); ; Abstract Introduction.The behavioral patterns, eating habits and participation in physical activities of university students have important influence on body composition of this young population group. The aim of this study was to determine the level of overweight and obesity in female medical students and level of physical activity. Material and methods. A descriptive cross-sectional study was conducted at Faculty of Medicine, Ss. Cyril and Methodius University in Skopje between December 2019 and April 2020. A total of 308 girls, students of the 1st and 2nd year of study, underwent body composition testing with InBody 720 bioimpedance analyzer. International physical activity questionnaire (IPAQ) was used for determining the level of physical activity. Results. The average age of participants was 19.4 1.1 years, and the mean values for obesity parameters were as followed: BMI = 22.5 4.3 kg/m2 ; BF% = 28.3 8.5; WHR= 0.87 0.07. One third of students had normal body fat percentage (34.5%) and waist-to-hip ratio (33.3%). Two thirds of students showed normal BMI, and 14.6% of girls were overweight while 6% were obese according to BMI. The greatest percentage of students, 60% of girls, showed BF% and WHR higher than normal values. Conclusion. Analysis of obesity parameters derived from bioimpedance analyzer – (BIA) showed that BMI parameter was less sensitive to level of obesity than BF% and WHR. The findings revealed that more than half of the young female medical students were overweight and/or obese. Key words: obesity, body mass index, body fat, waist to hip ratio, students - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Leptin, obesity parameters and atopy among children with asthma(Macedonian Academy of Sciences and Arts / De Gruyter, 2021-10-26); ; ; ; Leptin, as a major adipokine, positively correlates with the body’s fat, while atopy is an important feature in the development of childhood asthma. We aimed to evaluate the relationship between leptin, parameters of obesity, and atopy in children with asthma. The study included 112 children (73 boys, 39 girls, mean age 11.1±2.4). 41 were overweight, 38 had asthma and a normal body mass index (BMI), and 33 were overweight asthmatics. Serum leptin levels, BMI, waist circumference (WC), and waist to hips ratio (WHR) were measured. Skin prick test (SPT)/CAP, total serum IgE, fractional exhaled nitric oxide (FeNO), and pulmonary function tests were performed. In asthmatic children, serum leptin median level was 9.2±16.2 ng/ml, in overweight children was 30.6±21.6 ng/ml, and in overweight asthmatics was 31.1±20.3 ng/ml with a significant difference between the groups (p=0.0374), yet with a significantly lower median level in the group of children with asthma compared to the overweight children: with asthma (p=0.00001) and without asthma (p=0.00001). In the three groups of patients, BMI and WC displayed a significant positive correlation with leptin (for BMI r=0.652 vs. r=0.530 vs. r=0.563, respectively and for WC r=0.508 vs. r=0.426 vs. r=0.527, respectively). No significant correlations of leptin within atopy parameters (Eo, IgE, SPT/CAP, FeNO) in all three analyzed groups (p>0.05) was detected.Conclusion: Atopy was not confirmed as an underlying mechanism of the association between asthma and being overweight. Leptin had a significant linear correlation as a parameter of central obesity with BMI and WC in all three groups, but not with WHR. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, QUALITY OF LIFE, FORCED EXPIRATORY VOLUME IN ONE SECOND AND BODY MASS INDEX IN PATIENTS WITH COPD, DURING THERAPY FOR CONTROLLING THE DISEASE(Macedonian Academy of Sciences and Arts, 2009); Stevcevska G.Abstract: Patients with chronic obstructive pulmonary disease (COPD) are characterized by an impaired lung function and limited exercise tolerance. Medication and rehabilitation programmes are generally directed towards relief of symptoms and improvement of lung function and exercise tolerance. 130 patients were included in the examination with diagnosed chronic obstructtive pulmonary disease, stable form, 114 male and 16 female, of whom 121 were smokers and 9 were non-smokers. Inclusive criteria were FEV1 < 50% from predicted (with moderate and severe level of the disease), the relation FEV1/FVC < 70%, the test of reversibility with β2-agonist < 15%. The patients were followed up for 18 months. They were evaluated at the start, and then at the end of the study. During the examination 9 patients were excluded because they did not obey recommendations of the examination, and three patients died during the examination. At the end of our study 77 patients in group I, 66 male and 11 female, were evaluated, and 41 patients, 35 male and 6 female, in group II. The patients were divided on the basis of BMI (body mass index), group I with BMI from 21 to 28 kg/m2 and group II with BMI < 21 kg/m2 . The mean age of the patients was 63 ± 7.2 years in group I, and 68 ± 8.3 in group II. The values of FEV1 at the start were 1.33 ± 0.35L (43 ± 8.1%) in group I, and 0.89 ± 0.27 L (28 ± 7.9%) in group II. Both were significantly lower in group II (p < 0.001). At the end of the study the values of FEV1 were lower in both groups than at the start (Fig. 1). At the start of the study SGRQ scores in group I were significantly lower (p < 0.001) than in group II. This indicated a better quality of life in patients with BMI from 21 to 28 kg/m2 . The SGRQ scores at the end of the study were also significantly lower in group I (p < 0.001). And they were lower than at the start in both groups, indicating a better quality of life in patients with COPD after18 months’ regular use of therapy (Fig. 2). The values of Pearson’s coefficient r = -0.49 (p < 0.05) in group I and r = -0.35 (0.05) in group II, shows that between these two variables there is an indirect, or negative correlation; lower values of FEV1 are associated with higher SGRQ total scores. It can be concluded that regular use of therapy for controlling the disease leads to improved quality of life in COPD patients, which is not associated with improvement in lung function. Patients with malnutrition (BMI < 21kg/m2 ) have lower values of FEV1, and they have higher SGRQ scores of quality of life. High levels of SGRQ scores are associated with lower values of FEV1. Key words: COPD, therapy, quality of life, forced expiratory volume in one second, body mass index. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Insulin resistance in patients with chronic hepatitis C(Македонско лекарско друштво = Macedonian Medical Association, 2016); ; ; ; Introduction: Insulin resistance is the most common extrahepatic manifestation associated with hepatitis C virus, which leads to developing more pronounced fibrosis and liver steatosis. The aim of the study was to assess the prevalence of insulin resistance in non-diabetic, treatment naive patients with chronic hepatitis C and to analyze the relation of insulin resistance with genotype, viral load, gender, age, laboratory parameters, inflammatory and fibrotic changes in the liver, body mass index (BMI) and the presence of steatosis. Material and methods: In this cross sectional study, 224 patients with hepatitis C viral infection were included. The patients were divided into two groups. The first group was with no insulin resistance and the second one with present insulin resistance. They were compared in terms of genotype, viral load, gender, age, inflammatory and fibrotic changes in the liver, BMI and liver steatosis. Results: Insulin resistance was present in 45.5% of patients. The following factors were associated with insulin resistance: age (p = 0.0022), inflammatory and fibrotic changes in the liver (p = 0.001, p = 0.006, respectively), steatosis (p = 0.015) and transaminase activities (for AST, p = 0,002, for ALT, p = 0.001). Conclusion: In the Republic of Macedonia, high percentage of 45.5% among non-diabetic and treatment naïve patients with chronic viral hepatitis C, had insulin resistance. Insulin resistance was more prevalent in older patients, in those with more pronounced inflammatory and fibrotic changes in the liver, in patients with steatosis and in those with higher transaminase activity. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The association between BMI, vigorous physical activity and television viewing and the risk of symptoms of asthma, rhinoconjunctivitis and eczema in children and adolescents: ISAAC Phase Three(Wiley, 2013-01) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Maternal post-natal tobacco use and current parental tobacco use is associated with higher body mass index in children and adolescents: an international cross-sectional study(Springer Science and Business Media LLC, 2015-12-24)