Faculty of Medicine
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Item type:Publication, NGAL and HPV Subtypes in Cervical Carcinoma: Implications for Cancer Progression and Treatment Response(MDPI AG, 2026-02-23); ; Background/Objectives: Cervical cancer is a prominent source of morbidity and mortality among women, particularly in low- and middle-income nations. Neutrophil Gelatinase-Associated Lipocalin (NGAL), a glycoprotein involved in cancer-related activities, has been proposed as a biomarker; however, its involvement in cervical cancer remains unknown. The study aim is to evaluate the prognostic significance of serum NGAL levels in cervical cancer patients in relation to International Federation of Gynecology and Obstetrics (FIGO) stage, operability, and HPV subtype distribution before and after treatment. Methods: The study involved 130 women, 100 with histologically proven cervical cancer and 30 healthy controls. The serum NGAL levels were determined before and after treatment using an ELISA test. HPV genotyping was carried out using real-time PCR on 21 high- and low-risk subtypes. Results: NGAL levels increased marginally during therapy (from 134 to 144 ng/mL; p = 0.28), but the rise was significant in inoperable patients (p = 0.02) and increased with advanced FIGO stage, although this did not reach statistical significance (p = 0.07). HPV 16 was the most common subtype (26.0%), while women aged 51–60 had the highest overall HPV positive rate (72.7%). There was no significant association between NGAL levels and HPV subtypes (p = 0.17). Conclusion: NGAL does not appear to be an accurate short-term indicator of therapy response. However, increased levels in advanced-stage and inoperable instances indicate prognostic significance. NGAL most likely represents tumor-associated inflammation rather than HPV subtype. These findings support its possible inclusion in future biomarker panels, subject to validation in bigger investigations. Persistent HPV infection in midlife women highlights the significance of ongoing screening.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Molecular and Immunohistochemical Biomarkers in Colorectal Carcinoma - A Single Center Study(Walter de Gruyter GmbH, 2025-06); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, MATERNAL PLASMA BIOMARKERS (ANTITHROMBIN 3, PLASMOINOGEN ACTIVATOR INHIBITOR 1, SOLUBLE TIE 2, VASCULАR ENDOTHELIAL GROWTH FACTOR RECEPTOR2) AS INDICATORS FOR PLACENTA ACCRETA SPECTRUM (PAS) IN THE THIRD TRIMESTER OF PREGNANCY(SHMSHM - AAMD, 2022-04); ; ; ; Gjoreski, JosifIntroduction: Placenta accreta spectrum (PAS)- an abnormally adherent placenta into the uterine wall with the inability to properly detach after the birth of the fetus. Factors that increase the risk of PAS are: regions of poorly developed decidua, previous caesarean section/s, etc. Materials and Methods: This study is a prospective cohort study conducted at The University Clinic of Gynecology and Obstetrics Skopje, Republic of North Macedonia in February and March 2021. The study involved 8 patients, diagnosed with PAS, from whom maternal plasma samples were taken. Measurements of concentration of antithrombin III, plasminogen activator inhibitor 1(PAI1), soluble Tie 2 (sol Tie2), vascular endothelial growth factor receptor 2(VEGFR2), in the third trimester of pregnancy were done. Results: In all 8 patients, a PAS diagnosis was detected. In previous ultrasound findings, placenta praevia was diagnosed in 4 of 8 patients, and the remaining 4 had ultrasound signs for placenta accreta. In terms of biomarker values, we received significant values in all 4 biomarkers we examined. Conclusion: The examination of these biomarkers is useful for predicting and early diagnosis of PAS. We confirmed antithrombin III, PAI-1, soluble Tie2 and soluble VEGF 2 receptor as new biomarkers for this condition. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Biomarkers of oxidative stress in patients with acute coronary syndrome(2016-05-16); ; Purpose: To evaluate comparatively association between biomarkers of oxidative stress(OS) in patients with acute vs chronic coronary artery disease, and in comparison with healthy volunteers. Methods :Cross-sectional observational study was performed in patients admitted because of coronary artery disease (CAD). Pts were evaluated for their demographics, risk factors and co-morbidities, lipoprotein profile, HgbA1C and markers of oxidative stress: malondialdehyde (MDA) and hydroperoxids (HP), and antioxidant enzymes: superoxide dizmutaza (SOD), CATALASE and glutathione peroxidase (GPS). Pts were divided in 2 groups: pts with acute coronary syndrome (ACS) and chronic coronary artery disease (HCAD), and then subdivided, ACS pts in: STEMI, NSTEMI and APNS, HCAD in: asymptomatic CAD, revascularized and post MI patients. Statistical analysis: descriptive, t-test, ANOVA, Kruskall-Wallis ANOVA, correlation. Significance was determined at level of 0.05.Results :300 pts. 194 males and 106 females at mean age of 62.9±11,2 y were analyzed. 187 were with ACS and 113 with HCAD. 62,3% of pts. had HTA, 42,7% HLP, 28,3% DM, 57% smokers, 8% had anemia. There was no significant difference in the risk profile between the two groups. Mean values of the markers of OS (Table 1). Statistically significant differences didn’t existed between ACS and HCAD groups but inside the groups(Table 1), in lipid profile and HgbA1C in ACAD pts compared to HCAD.ACAD pts had higher HgbA1C, total, LDL and ApoB, but lower HDL-C and ApoA1. Correlation was found for HgbA1C and MDA (r=-,154**, p=0,008); age and total HP (r=-,143*, p=0,013); ApoA1 and total HP (r=-,157*, p=0,035);Conclusion: Markers of oxidative stress were significantly higher, and antioxidative activity was lower compared to healthy volunteers, but between ACAD and HCAD group significant differences were found only for HP from pro-oxidative, and SOD from anti-oxidative markers. Inside the groups, revascularized HCAD pts were with the highest pro-oxidative and lowest anti-oxidative activity, while in ACAD group, different markers of OS were the most pathological in different ACAD groups - Some of the metrics are blocked by yourconsent settings
Item type:Publication, NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN AS AN EARLY BIOMARKER OF ACUTE KIDNEY INJURY IN NEWBORNS(Klinički bolnički centar Sestre milosrdnice, Zagreb, 2020); ;