Faculty of Medicine
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Item type:Publication, BODY FAT DISTRIBUTION CHANGES DURING WEIGHT LOSS DETERMINED BY DUAL-ENERGY X-RAY ABSORPTIOMETRIC INDEXES OF ABDOMINAL OBESITY(2019); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, DYSLIPIDEMIC PROFILE IN HEALTHY WOMEN IN RELATION TO BODY FAT DISTRIBUTION(Macedonian Pharmaceutical Association, 2020); Abdominal obesity is associated with particularly adverse lipidemic profile. The aim of this study was to determine the characteristics of the dyslipidemic profile in healthy women with extreme abdominal obesity determined anthropometrically. Lipid profile and atherogenic indexes were determined in 80 healthy women, grouped in 4 groups according to their body mass index (BMI) and grouped in 3 groups according to their body fat distribution (BFD) by means of nthropometric indexes waist/hip ratio (WHR) and waist/thigh ratio circumference (WTR): group M with normal BFD (WHR<0.85 and WTR<1.45), group N with moderate (WHR 0.85-1 and WTR 1.45-1.7) and group O with extremely expressed abdominal BFD. HDL-cholesterol (HDL-C) levels (0.84±0.26mmol/L) were significantly lowest in group O (p<0.002), and significantly lower compared to group N (1.14±0.43mmol/L) (p<0.006). Triglyceride (TG) levels were significantly higher in group O compared to group M (p<0.001) and also higher in group N compared to group M (p<0.044). Atherogenic indexes C/HDL-C, LDL/HDL-C and TG/HDL-C values in group O were significantly higher compared to the corresponding values in group M (p<0.004; p< 0.006; p<0.001), and their values were also higher in group O compared to group N, but with lower significance of the difference (p<0.05) indicating lower increase of the atherogenic indexes in moderate and significant increase in women with extreme abdominal obesity. Dyslipidemic profile and high atherogenic indexes in women with abdominal obesity with significantly highest WHR, WTR and BMI values indicated the need to intervene earlier and more effectively in the prevention and treatment of cardiovascular and metabolic risks. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Lipid profile changes relations to body fat distribution changes determined with dual-energy x-ray absorptiometry during the weight loss(Institute of Knowledge Management, 2019); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, BODY FAT DISTRIBUTION CHANGES DURING WIGHT LOSS DETERMINED BY DXA ANDROID/GYNOID INDEXES OF ABDOMINAL OBESITY(Medical faculty, Ss Cyril and Methodius University Skopje, 2019); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, NEW DXA DIAGNOSTIC INDEXES OF ABDOMINAL OBESITY(Macedonian Academy of sciences and Arts, 2021-02); ; ; ; Aim: Cushing’s syndrome (CS) is associated with weight gain and extreme central, visceral, abdominal obesity which is confirmed with dual-energy X-rays absorptiometric (DXA) diagnostic cut-off point (CP) values of central obesity indexes (COI), determined as an android to gynoid tissue and fat mass ratios. These best differentiate CS from non-CS obese women matched with CS according to their age and BMI. The aim of this study was to determine the CP values of new DXA indexes of central, abdominal obesity as a ratio of android and trunk to legs as well as trunk and legs to total tissue and fat mass that best differentiate CS and matched non-CS obese women in order to confirm central abdominal obesity, and to determine their normal CP values that best differentiate healthy non-obese women from CS and non-CS obese women, and to exclude abdominal obesity completely. Material and Methods: DXA indexes of abdominal obesity, calculated as а ratio of regional body fat and tissue mass compartments android to legs (A/L), trunk to legs (Tr/L), trunk to total (Tr/To) and legs to total (L/To) values were determined among 4 groups. Each group consisted of 18 women: 1st group of CS, 2nd group of obese women (O1) not different according to their age and BMI from CS, 3rd group of obese women (O2) with higher BMI of 35 ± 1.2 kg and a 4th group of non-obese, healthy women (C) with a normal BMI. Diagnostic accuracy (DG) of CP values of DXA indexes of abdominal obesity and indexes of normal body fat distribution (BFD) were determined. Results: A/L, Tr/L, Tr/To, and L/To DXA indexes were significantly different between CS and O1 as well as between non-CS women O2 compared to O1 and C. These indexes had a highly significant correlation among each other and also in relation to their BMI (p < 0.0001). A/L-Tm CP value of 0.3 best differentiated the CS from group O1, with the highest DG of 100 % and an A/L-Fm CP value of 0.26 differentiated them with a DG of 94.44% and sensitivity of 100 %. An A/L-Tn CP value of 0.23 and an A/L-Fn CP value of 0.25 best differentiated CS and C as well as O2 and C for the highest DG of 100 %. Conclusions: DXA indexes A/L, Tr/L, Tr/To and L/To values were significantly different among the four groups. These values correlated significantly among them and with their BMI in non-CS groups, thus confirming a BMI increase association with a more pronounced abdominal BFD. An A/L-Tm CP value of 0.3 and an A/L-Fm CP value of 0.26 were discovered as the best DXA diagnostic indexes of extreme abdominal obesity in CS and these could also be used in discovering abdominal BFD in non-CS obese women with metabolic syndrome (MS). An A/L-Tn CP value of 0.23 and an A/L-Fn CP value of 0.25 were discovered as the best DXA diagnostic indexes of normal BFD which completely excluded abdominal obesity. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Dual-energy X-ray absorptiometric assessment of android to legs ratio index of abdominal obesity in women(Sievert Association, 2021-09); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Indicators of abdominal obesity: waist circumference and waist-to-hip ratio in adolescence of North Macedonia(Macedonian Association of Anatomists, 2021-04-02); ; ; ; Obesity in children and adolescents in the world is reaching a scale of an epidemic. It is considered the most widespread disease in children in many countries, especially in developed countries. The aim of this study was to define WC and WHR among Macedonian adolescents aged 11 to 14 years. A cross-sectional study was performed in 2013-2015, comprising a sample of 1267 adolescents of the Republic of Macedonia aged 11 to 14 years; 646 males and 621 females. Weight, height, body mass index (BMI), waist circumference (WC), hip circumference (HC) and waist-to-hip ratio (WHR) were measured and percentiles were calculated using Cole’s Lambda, Mu and Sigma (LMS) method. The relation between WHR and general obesity, as defined by the International Obesity Task Force, was investigated with receiver operating characteristic (ROC) analysis. The boys had statistically significant higher values in all anthropometric measures, except in HC where statistically significant gender differences were not found. BMI, WC, and HC increased with the age. The obtained reference percentile curves can be used temporarily for obesity screening in children and adolescents. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, DIAGNOSTIC CENTRAL OBESITY INDEXES CUT – OFF POINT VALUES DETERMINED WITH DUAL-ENERGY X-RAY ABSORPTIOMETRY IN CUSHING’S AND OBESE WOMEN(Macedonian Academy of Sciences and Arts, 2020); ; ; Aim: The aim of this study was to develop quantiative criteria for defining visceral obesity and to establish dual-energy X-ray absorptiometric (DXA) diagnostic cut-off points (CP) for normal and abnormal values of the central obesity indexes (COI) that best differentiate extreme visceral obesity in Cushing’s syndrome (CS) from non CS obese and non obese women. Material and Methods: COI1–4 values calculated as a ratio of android to gynoid tissue mass, fat mass and their % were determined in 4 groups, each consisting of 18 women: 1st group of CS, 2nd group of obese women (O1 ) not different according to their age and BMI from CS, 3rd group of obese women (O2 ) with BMI of 35 ± 1.2 kg and 4th group of non obese healthy women (C) with normal BMI. Diagnostic accuracy (DG) of CP values of COI1m-4m indexes of abdominal obesity and CP values of COI1n-4n indexes of normal body fat distribution (BFD) was determined. Results: COI1-4 indexes values were highly significantly different among the 4 examined groups and were significantly highest in CS patients and lowest in group C (p < 0.0001). COI1m-4m CP values differentiated extreme visceral, abdominal obesity in CS with highest DG as well as COI1n-4n CP values differentiated normal BFD in group C. COI1m CP of 0.55 best differentiated CS from O1 for DG of 100%. COI2n of 0.38 best differentiated C from CS and O2 for highest DG of 100% compared to O1 because of the significantly higher BMI and COI1n-4n values in O2 that were associated with more pronounced abdominal obesity and highly significantly positive correlation with BMI. Conclusions: DXA cut-off point values of indexes COI1m-4m and COI1n-4n were established as diagnostic indexes and criteria useful in discovering extreme abdominal and normal BFD. COI1m CP value of 0.55 was discovered as a diagnostic criterion of extreme abdominal obesity and COI2n of 0.38 as a diagnostic criterion of normal BFD that excluded abdominal obesity. The other indexes COI1m-4m and COI1n-4n CP values had also high DG in discovering abdominal and normal body fat distribution. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, BODY FAT DISTRIBUTION CHANGES DURING WEIGHT LOSS DETERMINED BY DUAL-ENERGY X-RAY ABSORPTIOMETRIC TRUNK/ TOTAL RATIOS AS INDEXES OF ABDOMINAL OBESITY(SHMSHM / AAMD, 2019); ; Objective. The effect of weight loss on body fat distribution was examined through the trunk/total tissue and fat mass ratios, indexes of central, abdominal obesity determined by dual-energy X-ray absorptiometry (DXA). Material and methods. Following parameters were determined before and after weight loss: body mass index (BMI), body weight (BW), total and trunk fat mass (FM) and its percent (FM%), tissue mass (TM) and TM fat percent (TMf%) with DXA as well as DXA indexes of abdominal body fat distribution: trunk/total FM (Tr/To FM) and Tr/To FM%, trunk/total TM (Tr/To TM) and trunk/total TMf% (Tr/To TMf%) in two overweight subjects. Results. BW of 62.9±1.2 kg and BMI value of 28.98±0.78 kg/m2 before the weight loss lowered to 49.96±1.3 kg (p<0.012) and normal BMI 22.81±0.62 kg/m2 (p<0.012). Tr/To TMf% value decrease from 1.02±0.01 to 0.97±0.03 was significant (p<0.013) and Tr/To FM% value decrease from 1.04±0.01 to 0.99±0.02 was also significant (p<0.01). Tr/ To TM value decreased significantly from 0.55±0.02 to normal value 0.48±0.02 (p<0.019). Tr/To FM index value decreased significantly from 0.56±0.02 to normal value 0.48±0.03 (p<0.033). Tr/To TM and Tr/To FM after weight loss reached normal values. Conclusions. It was confirmed that DXA indexes of central, abdominal obesity Tr/To TM and Tr/To FM were increased in overweight subjects before the weight loss and lowered significantly after the weight loss to normal values, indicating that normal BMI and BW reached after the weight loss were associated with normalized body fat distribution - Some of the metrics are blocked by yourconsent settings
Item type:Publication, DIAGNOSING ABDOMINAL OBESITY IN WOMEN WITH CUT – OFF POINT VALUES OF THE ESTIMATED CENTRAL OBESITY INDEX DETERMINED WITH DUAL-ENERGY X-RAY ABSORPTIOMETRY(Macedonian Association of Anatomists and Morphologists, 2020); ; Introduction: Dual-energy X-ray absorptiometric (DXA), central obesity index (COI) and estimated COI (eCOI) are useful diagnostic DXA test procedures of extreme central, abdominal obesity in Cushing’s syndrome (CS) and non CS abdominally obese women, and determination of their diagnostic cut-off point values (CPV) is very important. Materials and methods: COI and eCOI values were determined in 3 groups, each consisting of 18 women: 1st group of CS, 2nd group of obese women (O) not different according to their age and Body Mass Index (BMI) with CS and 3rd group of non-obese healthy women (C) with normal BMI. COI1 and eCOI1 CPV were used to best differentiate CS and O. COI2 and eCOI2 CPV were used to best differentiate CS and O with C. Their diagnostic accuracy (DG), sensitivity (S) and specificity (SP) were determined. Results: COI and eCOI values were significantly different among the 3 groups. COI1 CPV of 0.9 best differentiated CS from O with DG of 70% and sensitivity of 90% but eCOI1 CPV of 0.92 differentiated them with DG of 75% and S of 100%. COI2 CPV of 0.82 best differentiated C from O with DG of 82.14% and SP of 88.89% as well as eCOI2 CPV of 0.84 differentiated them for DG of 75% and SP of 80%. COI2 CPV of 0.82 and eCOI2 0.84 best differentiated CS from C in both cases for DG of 92.86% and SP of 88.89%. Conclusion: Cut-off point values of COI1 and COI2 as well as eCOI1 and eCOI2 are very important diagnostic test procedures in discovering abdominal and normal body fat distribution. Determined eCOI1 and eCOI2 cut-off point values are especially very useful diagnostic screening tests of body fat distribution in everyday routine clinical praxis during spine and hip bone mineral content assessment.