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Subject: search.filters.subject.Streptococcus pneumoniae

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    Managing penicillin resistant pneumococcal meningitis: an international id-iri study.
    (Springer Science and Business Media LLC, 2025-09)
    Erdem H,
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    Dogan E,
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    Ankarali H,
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    Dragovac G,
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    Seyman D,
    Penicillin-resistant pneumococcal meningitis (PRPM) is a challenging and fatal infection. We conducted a multicentre international retrospective study to evaluate the clinical features, outcomes, predictors of outcomes antimicrobial efficacy and drug susceptibility in patients with PRPM. The study, conducted through the "Infectious Diseases-International Research Initiative" across 33 centers in 11 countries, analyzed PRPM patients treated between 2019 and 2024 using univariate and multivariate analyses. A total of 138 patients were included. Of these, 83 (60.1%) were fully cured, 27 (19.6%) died, and 28 (20.3%) survived with sequelae. Mortality was associated with ICU admission (OR 14.886; p = 0.021), mechanical ventilation (OR 7.205; p = 0.049), and vasopressor use (OR 8.983; p = 0.025). Higher CSF leukocyte count (OR 0.854; p = 0.060) and blood leukocyte count (OR 0.283; p = 0.021) were linked to lower mortality risk. Patients who developed sequelae were more likely to require mechanical ventilation (OR 9.354; p = 0.001), experience recurrent meningitis (OR 5.562; p = 0.081), and have lower platelet counts (OR 0.001; p = 0.050), compared to those who fully recovered. Sequelae patients had higher GCS scores (OR 1.365; p = 0.014), more corticosteroid use (OR 5.301; p = 0.061), and less vasopressor use (OR 0.205; p = 0.019) compared to those who died. The antibiotic susceptibility profiles of the isolates in our PRSP cohort were: Ceftriaxone (75/134, 55.9%), meropenem (26/44, 59%), moxifloxacin (47/48, 97.9%). PRPM is a fatal disease in which mortality and sequelae occurring in two-fifths of cases. Severe illness markers such as ICU admission, mechanical ventilation, and vasopressor use, along with recurrent meningitis are linked to worse outcomes. Thrombocytopenia, low leukocyte counts, and lower GCS scores are indicators of poor prognosis, while corticosteroid therapy appears protective in PRPM. Therapeutic optimization is challenged by rising resistance and pharmacokinetic limitations, though moxifloxacin shows the highest susceptibility; further research is warranted. Keywords: Meningitis; Penicillin; Pneumococci; Resistant; Streptococcus pneumoniae.
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    Sputum quality assessment regarding sputum culture for diagnosing lower respiratory tract infections in children.
    (ID Design Press,Skopje, Republic of Macedonia, 2019-06-30)
    Popova, Gorica
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    Spasova Smilevska, Olga
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    BACKGROUND:The clinical relevance of specimens from the lower airways is often debatable. However, they are most commonly examined for diagnosing lower respiratory tract infections (LRTIs).AIM:This study aimedto determine the diagnostic value of sputum quality assessment aboutsputum culture for diagnosing LRTIs in children.METHODS:In six months, a total of 1485 sputum samples were quality assessed by using Bartlett’s grading system. All samples, regardless of their quality, were cultured, identified, and antimicrobial susceptibility testing was performed by Kirby-Bauer disc-diffusion method.RESULTS:Among the acceptable category, defined by Bartlett’s grading system, 132 (63.2%) samples showed culture positivity of which Streptococcus pneumoniae48 (36.4%) was most commonly isolated, followed by Moraxella catarrhalis22 (16.7%) and Haemophilus influenza21 (15.9%). Among the non-acceptable category, 185 (14.5%) samples were culture positive of which most commonly isolated were Escherichia coli, Staphylococcus aureusand Pseudomonas aeruginosawith 64 (34.6%), 54 (29.2%) and 28 (15.1%), respectively.CONCLUSION:Sputum quality assessment is a useful tool for distinguishing the true respiratory pathogens from possible colonising flora for which antibiotic treatment should not be highly considered.
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    Acute encephalitis caused by Streptococcus pneumoniae: case report and review of the literature
    (Croatian Academy of Sciences and Arts – Medical Sciences, 2022-06-30)
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    Jacheva, Ivana
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    Gjorgieva, Snezhana
    Introduction: Streptococcus pneumoniae (pneumococcus), is a Gram-positive, spherical bacteria, member of the genus Streptococcus. It resides asymptomatically in healthy carriers typically colonizing the respiratory tract, sinuses, and nasal cavity. However, in susceptible individuals with weaker immune systems, pneumococcus may become pathogenic and spread to other locations causing cardiorespiratory and bone diseases as well as meningitis. Encephalitis and brain abscesses caused by Streptococcus pneumoniae are rare entities and they account for less than 1% of all bacterial brain abscesses. Purpose: We aim to present a case report of an acute encephalitis in a 16 years old female patient caused by Streptococcus pneumoniae, with review of the literature. Case Report: A 16 years old, right-handed female, was hospitalized at the clinic due to impaired consciousness (coma) and decerebrate posturing. The symptoms started the previous days with vomiting, drowsiness, subfebrile temperature and were originally perceived as food poisoning. Laboratory blood analysis were normal at the beginning and despite supportive therapy, deterioration of the clinical condition occurred, followed by confusion, muscle weakness and collapse. These symptoms were initially addressed as a functional neurological symptom disorder and the patient was referred to a psychiatrist. However, the patient’s condition got worse, with febrile symptoms, while the control laboratory blood examination showed signs of infectious syndrome. The patient was seen by infectologist and COVID-19 test was performed, with negative result. The analysis of CSF found bacterial infiltration, while the PCR test isolated Streptococcus pneumoniae. MRI of the brain (native and with contrast) showed bilateral multiple microabscesses, predominantly in the frontal and parietal regions. After the diagnosis was confirmed, the patient was treated promptly with antiedematous, antibiotic, neuroprotective and other symptomatic therapy for a period of 2 months. Her condition gradually improved completely, with amelioration of the state of consciousness and muscle weakness as well. Control laboratory blood analysis and CSF examination showed improvement as well, while the MRI of the brain displayed reduction of the previously described lesions and edema. Conclusion: The atypical clinical picture may sometimes mislead the treating physician. Cases with encephalitis caused by Streptococcus pneumoniae have been rarely described in the literature, however, early recognition and adequate treatment are crucial for the positive outcome.