Faculty of Medicine
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Item type:Publication, Impact of Lactobacillus Reuteri and Three Other Probiotics in Helicobacter Pylori Eradication(Scientific Foundation Spiroski, 2022); Alidema, FilipAIM: The aim of the study was to assess the effectiveness and safeness of Lactobacillus reuteri and additionally three other probiotics to conventional triple therapy against Heliobacter pylori. MATERIALS AND METHODS: We randomly selected 115 H. pylori positive dyspeptic patients, to be treated for 14 days with conventional triple therapy, without and with probiotics. Our first group of 62 patients received conventional triple therapy, while the second group of 53 patients was treated with L. reuteri and Lactobacillus casei, Lactobacillus acidophilus, and Bifidobacterium lactis, all encapsulated in PharmaS Helicobalans capsules alongside the conventional triple therapy. One month after completion of treatment, Helicobacter pylori presence was evaluated. If the H. pylori test would turn out negative, it would prove the success of the eradication. RESULTS: Thirty eight patients in the first group (61.3%) were successfully treated. In the second group, where probiotics were added, the success of eradication was observed in 37 of them (69.8%). Even though eradication was higher in the second group, the difference between the two sides in terms of statistics was not significant (p = 0.199). Regarding the side effects of ordered treatment, 27 patients in the first group (43.5%) had complaints, while the second group had 17(32%). Again, there was seen no difference statistically important between the two sides. CONCLUSION: Including probiotics additionally to conventional H. pylori treatment may decrease the side effects of the therapy and increase the H. pylori eradication success. Randomized and prospective work is needed on a larger scale. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Probiotics and Oral Health(2017-06); ; ; ; Maja PandilovaThe aim of this study was to evaluate the effects of probiotic lozenges as an adjunct to scaling and root planing (SRP) in chronic periodontitis patients. Thirty chronic periodontitis patients divided in examined group (SRP+ probiotic, n=15) and control group (SRP, n=15), were monitored clinically (plaque index(PI), the gingival index(GI), the probing pocket depth(PD), clinical attachment level(CAL) and microbiological parameters were recorded on day 0, and 1 month after therapy. The Prolife lozenges containing: Bacillus coagulans (Lactobacillus sporogenes), Lactobacillus acidophilus, Streptococcus thermophilus, Lactobacillus bulgaricus, Bifidobacterium bifidum (≥ 2,1 x 109), were used two times a day for 15 days. PI and GI were significantly reduced in both groups (p < 0.05) after the treatment. PD in examined group of 4,93 0,7mm decreased to 3,960,8 mm (p>0,05), versus mean PD of 5,2 0,7 mm in control group that was equally after the treatment (p>0,05). CAL gains of 4,21,3 mm to 3,861,3mm in the examined group versus 4,361,2 mm to 4,2 1,2 (p>0,05) in control group. Microbiological examination demonstrated decreased of quantum of above 100 bacterial colonies of anaerobes and facultative anaerobes, from 66,7% to 33,3% in the examined group, according to 53,3% to 46,7% in control group. Despite data indicate an effect of probiotics on the oral microbiota and a more limited effect on clinical periodontal outcome measures, it can be recommended as a useful adjunct to SRP in chronic periodontitis patients.