Faculty of Medicine
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Item type:Publication, Y-chromosome diversity of the three major ethno-linguistic groups in the Republic of North Macedonia(Elsevier BV, 2019-09); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Somatotype in 11 years old Macedonian adolescents(Macedonian Association of Anatomists and Morphologists, 2018-04-12); ; ; ; Kavecan, IvanaObjectives. The aim of this study was to evaluate sex and ethnic differences of somatotype in Macedonian adolescents at the age of 11 years. Subjects and Methods. In this study 315 adolescent students (167 males and 148 females), from Macedonian and Albanian nationality at age of 11 years were included from primary schools in two cities: Skopje and Strumica in R. Macedonia. Ten anthropometric parameters were measured using standard equipment and measurement technique to assess the somatotype according to Heat–Carter somatotyping method. Results. Although there were not significant sex and ethnic differences of somatotype components between the groups at the age of 11 years, from the obtained results we concluded that males and females of Macedonian ethnic group had higher values for endomorph component than their Albanian pears, who had higher values for mesomorph and ectomoph component. Conclusion. Ethnic group should be taken in mind for easier evaluation and understanding of differences in anthropometric parameters of growth and body composition in Macedonian adolescents. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Investigation of SERPINE1 genetic polymorphism in Macedonian patients with occlusive artery disease and deep vein thrombosis(Medycyna Praktyczna, 2009-10); ; ; ; Dzhekova-Stojkova, SlobodaBACKGROUND: Raised SERPINE1 plasma levels are related to a 1-bp guanine deletion/insertion (4G5G) polymorphism in the promoter of the SERPINE1 (plasminogen activator inhibitor 1 - PAI1) gene. Evidence suggested that the plasma levels of SERPINE1 modulate the risk of coronary artery disease; furthermore, that the 4G5G polymorphism affects the expression of the SERPINE1 gene. AIM: To analyse association of SERPINE1 polymorphism with occlusive artery disease (OAD) and deep venous thrombosis (DVT) in Macedonians in order to investigate its role as a part of candidate genes in different vascular diseases in Macedonians. METHODS: Investigated groups consisted of 82 healthy patients, 75 with OAD, and 66 with DVT. Blood samples were collected after written informed consent was obtained, and DNA was isolated from peripheral blood leukocytes. Identification of SERPINE1 polymorphism was done with CVD StripAssay (ViennaLab, Labordiagnostica GmbH, Austria). The population genetics analysis package, PyPop, was used for analysis of the SERPINE1 data. Pearson's P-values, crude odds ratio and Wald's 95% CI were calculated with Bonferroni corrected p value. RESULTS: The frequency of 4G allele for SERPINE1 was 0.538 for DVT, 0.555 for healthy participants, and 0.607 for OAD. The frequency of 5G allele for SERPINE1 was the smallest in patients with OAD (0.393) and was higher in healthy participants (0.445), and patients with DVT (0.462). Test of neutrality (Fnd) showed negative value, but was significantly different from 0 for SERPINE1 in healthy participants (p of F = 0.041) and in patients with DVT (p of F = 0.030). SERPINE1 genotypes in healthy participants and patients with OAD were not in Hardy Weinberg proportions (p = 0.019 and 0.001, respectively). No association between SERPINE1 polymorphisms and OAD or DVT was found. CONCLUSION: There is no significant relationship between SERPINE1 polymorphisms and occlusive artery disease or deep venous thrombosis in Macedonian population. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Methylenetetrahydrofolate reductase (MTHFR-677 and MTHFR-1298) genotypes and haplotypes and plasma homocysteine levels in patients with occlusive artery disease and deep venous thrombosis(Panstwowe Wydawnictwo Naukowe, 2008);