Faculty of Medicine
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Item type:Publication, VIRAL ONCOPROTEINS E6 AND E7 IN WOMEN WITH AND WITHOUT SQUAMOUS INTRAEPITHELIAL LESIONS AND SQUAMOUS INVASIVE CERVICAL CANCER(Institute of Knowledge Management, 2020)The two most important viral oncoproteins in the process of cervical carcinogenesis are E6 and E7. The study is a retrospective cohort study. Material is represented by 192 patients aged 20 to 59 years, divided into two groups: examined and control. The study group included 128 sexually active women with abnormal cervical cytological findings, ie Pap smear, which shows the presence of squamous intraepithelial lesion or squamous invasive cervical cancer. The control group included 64 sexually active women with normal cervical cytological findings, ie PAP test. The study did not include: pregnant women, women with previous cervical surgery (conization, carbon dioxide laser vaporization, and total hysterectomy), with previous abnormal cytological and histopathological findings of the cervix, and women with menstrual bleeding. The study did not include: pregnant women, women with previous cervical surgery (conization, carbon dioxide laser vaporization, and total hysterectomy), with previous abnormal cytological and histopathological findings of the cervix, and women with menstrual bleeding. HPV E6 / E7 mRNA infection was detected in 60.94% of patients in the study group. Analysis of the data showed an increase in HPV E6 / E7 HPV mRNA infection, in parallel with an increase in the histopathological degree of cervical lesion. The lowest percentage was in LSIL 9.76% (4/41), with an increase of 92.59% (50/54) in HSIL and 95.83% (23/24) in invasive squamous cell carcinoma (p˂0.05). Data analysis showed an association between the presence of viral oncoproteins E6 and E7 and the occurrence of squamous intraepithelial lesions and squamous invasive cervical cancer (p <0.05). HPV E6 / E7 mRNA infection was detected in two (3.12%) patients in the control group. Our study has shown that there is an association between viral oncoproteins E6 and E7 and squamous intraepithelial lesions and squamous invasive cervical cancer. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, LIFESTYLE HABITS AS RISK FACTORS FOR SQUAMOUS CELL ABNORMALITIES OF THE UTERINE CERVIX(Institute of Knowledge Management, 2021)Studies have shown a positive correlation between cervical cancer and some lifestyle habits, such as cigarette smoking, alcohol consumption, drug use, and dieting. These risk factors basically increase the likelihood of exposure to a high-risk HPV genotype. The aim of our study was to detect the most common lifestyle habits as risk factors for squamous intraepithelial lesions and squamous invasive cervical cancer. The study is a case-control study. Material is represented by 192 patients aged 20 to 59 years, divided into two groups: examined and control. The study was conducted in the period from March 2019 to September 2020 at the University Clinics for Gynecology and Obstetrics and Radiotherapy and Oncology in Skopje. All women underwent: a survey with a specific questionnaire, and as an indication, all women in the study group and colposcopic cervical biopsy with endocervical curettage for histopathological analysis. The relative risk of squamous intraepithelial lesions and squamous invasive cervical cancer was assessed by calculating the odds ratio (OR, Odds Ratio) with a 95% Confidence Interval (CI, Confidence Interval), using logistic regression. Data analysis showed an association between cigarette smoking (chi-square test = 8.1702, p = 0.0043, p<0.05, with a relative risk of 2.45), diet (chisquare test = 4.1739, p = 0.0411, p<0.05, with a relative risk of 2.11) and squamous cell abnormalities of the cervix. Our study found that smoking and dieting were potential risk factors for cervical squamous cell abnormalities. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Примарен малигнен меланом на грлото на матката - приказ на случај(Македонско лекарско друштво = Macedonian medical association, 2001);