Faculty of Medicine
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Item type:Publication, Association of CURB-65 (Confusion, Urea, Respiratory Rate, Blood Pressure) with Mortality of Patients with Severe Community-Acquired Pneumonia(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2009); ; ; Background. Severe community-acquired pneumonia (sCAP) is serious, life-thretening condition, with high mortality rate. Scoring systems for disease severity are used for predicting mortality in patients with pneumonia. Objective of this study was to identify the parameters of CURB-65 score that have higher association with mortality in patients with severe CAP. Material and methods. One hundred and two patients with community-acquired pneumonia were enrolled in the study. The study was conducted at the Intensive Care Department of the Clinic for Infectious Diseases and Febrile Conditions-Skopje. Demographic, clinical and biochemical parameters were analyzed and CURB-65 was calculated in each patient at admission. Predictors were identified using logistic regression analysis. Receiver Operating Characteristic Curve (ROC) was constructed for assessing discriminative power of analyzed parameters. Results. CURB-65 identified severe CAP in 32 (31,4%) patients, with overall mortality rate of 62,5%. Confusion, respiratory rate > 30/min and urea > 7mmol/L had significant association with the mortality. Conclusion. CURB-65 is a simple tool that can identify patients with severe CAP and can be used for early prediction of patients mortality. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Phisyological and biochemical factors in predicting outcome in severe community-acquired pneumonia(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2008); ; The aim of our study was to identify physiologic and biochemical parameters of the patients on admission to hospital that will predict the death from severe community-acquired pneumonia. The study is a retrospective evaluation of patients with clinically and radiologically diagnosed community-acquired pneumonia, treated in the Intensive Care Unit of the Clinic for Infectious Diseases, Skopje, Macedonia in the period between 2003-2005. Eighty-one patients were included in the study, divided in two groups: group A - survivors and group B - non-survivors. Age, gender, symptoms before admission, co-morbidity, tobacco smoking, body temperature, heart rate, respiratory rate, arterial blood pressure, leukocytes count, haematocrit, glycemia, urea, sodium, serum albumen and arterial oxygen saturation were measured in each patient on admission. Results: Twenty-nine (35,8%) of all analyzed patients died, with mean age 63,1±17,9. From patients who died, 19 (43,2%) were males. Smoking, heart rate > 90/min, tachipnea ≥ 25/min., body temperature > 38, 5°C, leucocytes count > 10x10 9/L, uremia >7,4mmol/L and hypoxemia <90% were significantly associated with death on admission of patients with severe community-acquired pneumonia. In conclusion, severe community-acquired pneumonia is a serious life-threatening infection with high mortality. Identifying factors that predict adverse outcome on admission of the patients will contribute in undertaking appropriate treatment and management of this disease.