Faculty of Medicine
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Item type:Publication, PREVALENCE OF BACTERIAL VAGINOSIS(Institute of Knowledge Management, 2021)Bacterial vaginosis is a disorder in the composition of the vaginal flora that leads to a decrease in the number of hydrogen peroxide-producing lactobacilli and a predominance of various anaerobic bacteria. A retrospective cohort study, performed on a series of 192 patients aged 20 to 59 years, divided into two groups: study and control. The study group included 128 sexually active women with a Pap smear that showed the presence of a squamous intraepithelial lesion or squamous invasive cervical cancer. The control group included 64 sexually active women with a normal PAP test. In all women we done: Nugent's score system, and as indicated, all women in the study group and colposcopic cervical biopsy with endocervical curettage for histopathological analysis. Bacterial vaginosis was detected in 43.75% of patients with squamous cell abnormalities of the cervix and in 12.50% of patients with normal cervical cytology. Data analysis showed: correlation between the presence of bacterial vaginosis and the occurrence of squamous cell abnormalities of the cervix (chi-square test = 4.1906, p <0.05); increase in the presence of bacterial vaginosis with increasing cytopathological (chi-square test = 12,198, p˂0.05) and histopathological (chi-square test = 6.3434, p˂0.05) degree of cervical lesion and that bacterial vaginosis was most common in patients under 30 years of age (57.14%; 16/28). There is a statistically significant correlation between the modalities, the presence of bacterial vaginosis and the absence of bacterial vaginosis between the study and the control group (chi-square test = 18.75, p˂0.05). The percentage difference between the modalities presence of bacterial vaginosis and absence of bacterial vaginosis between the study and the control group was statistically insignificant for p˃0.05 (p = 0.1863, t = 1.9799, 95% CI = -138.8260-54,260). Our study showed an association between bacterial vaginosis and squamous cell abnormalities of the cervix. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ASSOCIATION BETWEEN HPV DNA INFECTION AND BACTERIAL VAGINOSIS IN WOMEN WITH SQUAMOUS CELL ABNORMALITIES OF THE UTERINE CERVIX(Institute of Knowledge Management, 2021-08)The aim of the study was to demonstrate an association between HPV-DNA infection and bacterial vaginosis in women with squamous intraepithelial lesions and squamous invasive cervical cancer, and to determine the prevalence of HPV-DNA infection and bacterial vaginosis. The material is 128 sexually active women with abnormal cervical cytological findings, ie Pap smear, which shows the presence of squamous intraepithelial lesion or squamous invasive cervical cancer, aged 20 to 59 years. The study did not include: pregnant women, women with previous cervical surgery (conization, carbon dioxide laser vaporization, and total hysterectomy), with previous abnormal cytological and histopathological findings of the cervix, women undergoing menstrual bleeding, the last six weeks have been or are under local or systemic antibiotic or antiviral therapy and women who have had sex for the last two days or have had a vaginal toilet. In women we done: HPV-DNA testing and Nugent score system. HPV-DNA infection was detected in 75.00% (96/128) of patients. Out of a total of 128 patients, bacterial vaginosis was found in 56 (43.75%) patients. Out of a total of 128 patients, 50 (39.06%) patients were found to have bacterial vaginosis and HPV-DNA infection at the same time. Out of a total of 96 HPV-DNA positive patients, bacterial vaginosis was present in 50 (52.08%) patients, and the absence of bacterial vaginosis was noted in 46 (47.92%) of HPV-DNA positive patients. Data analysis showed that there was an association between DNA-HPV infection and bacterial vaginosis (chi-square test = 10.836, p = 0.000995, p˂0.05). Our study showed that there is an association between HPV-DNA infection and bacterial vaginosis in women with squamous cell abnormalities of the uterine cervix. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, РИЗИК ФАКТОРИ НА СКВАМОЗНИТЕ КЛЕТОЧНИ АБНОРМАЛНОСТИ НА ГРЛОТО НА МАТКАТА(SHMSHM / AAMD, 2017); ; ; ; Duvlis, SotirijaВовед: Целта на нашата студија беше да ги детектираме најчестите ризик фактори на сквамозните интраепителни лезии и сквамозниот инвазивен карцином на грлото на матката. Материјал и методи: Case-control студија, работена на 192 сексуално активни жени, на возраст од 20 до 59 години, поделени во две групи: испитувана и контролна, на Универзитетските клиники за гинекологија и акушерство и радиотерапија и онкологија во Скопје и на Институтот за јавно здравје на Република Македонија, во периодот од Јануари 2016 година до Јуни 2017 година. Кај сите жени се направи: анкета со специфичен прашалник, ХПВ ДНК тестирање, Nugent-ов скор систем, а по индикација, кај сите жени од испитуваната група и колпоскопска цервикална биопсија со ендоцервикална киретажа за хистопатолошка анализа. Резултати: Анализата на податоците покажа асоцијација помеѓу ХПВ ДНК инфекцијата (хи квадрат тест=4.8204, p=0.028125, p<0.05), бактериската вагиноза (хи квадрат тест=4.1906, p=0.040649, p<0.05) и сквамозните клеточни абнормалности на грлото на матката. Нашата студија покажа дека пониското ниво на едукација за 2,29 пати (OR=2.29; 95%CI: 1.093-4.797) го зголемува ризикот за појава на сквамозни клеточни абнормалности на грлото на матката. Релативниот ризик за сквамозни клеточни абнормалности на грлото на матката, кај пациентките со понизок социјален статус беше 2,59 (OR=2.59; 95%CI: 1.137-5.503). Нашата студија покажа дека пушењето цигари за 2,45 пати го зголемува ризикот за појава на сквамозни клеточни абнормалности на грлото на матката (OR=2.45; 95%CI=1.3165-4.5762). Релативниот ризик за сквамозни клеточни абнормалности на грлото на матката, кај пациентките кои употребувале орални хормонски контрацептивни средства подолго од 5 години беше 3,00. Нашата студија покажа дека раниот прв сексуален однос пред 17 година од животот за 2,14 пати го зголемува ризикот за појава на сквамозните интраепителни лезии и сквамозниот инвазивен карцином на грлото на матката (OR=2.14; 95%CI: 1.0723-4.2821). Анализата на податоците од нашата студија покажа и асоцијација помеѓу сквамозните клеточни абнормалности на грлото на матката и диеталната исхрана (OR=2.11; 95%CI=1.0218-4.3832). Заклучок: Анализата на податоците на нашата студија покажа асоцијација помеѓу сквамозните клеточни абнормалности на грлото на матката и ХПВ ДНК инфекцијата, бактериската вагиноза, нередовните гинеколошки контроли, честиот вагинален исцедок, раниот прв сексуален однос, пушењето цигари, долготрајната употреба на хормонски орални контрацептивни средства и диеталната исхрана. Introduction: The purpose of our study was to detect the most common risk factors for squamous cell abnormalities of the uterine cervix. Material and methods: Case-control study, performed on 192 sexually active women aged 20 to 59, divided into two groups: examination and control, at the University Clinics of Gynecology and Obstetrics and Radiotherapy and Oncology in Skopje and the Institute for Public Health of the Republic of Macedonia, in the period from January 2016 to June 2017. All women were made: a questionnaire, HPV DNA testing, Nugent score system, and by indication, in all women in the study group and colposcopic cervical biopsy with endocervical curettage for histopathological analysis. Results: The analysis of the data showed an association between the presence of HPV DNA infection (chi-square test = 4.8204, p = 0.028125, p <0.05), bacterial vaginosis (chi-square test = 4.1906, p = 0.040649, p <0.05) and the occurrence of squamous intraepithelial lesions and squamous invasive carcinoma of the uterine cervix. Our study showed that the lower level of education for 2.29 times (OR = 2.29; 95% CI: 1.093-4.797) increased the risk of squamous cell abnormalities of the uterine cervix. The relative risk of squamous cell cervical abnormalities in patients with lower social status was 2.59 (OR = 2.59; 95% CI: 1.137-5.503). Our study showed that smoking cigarettes by 2.45 times increases the risk of squamous cell abnormalities of the uterine cervix (OR = 2.45; 95% CI: 1.3165-4.5762). The relative risk of squamous cell cervical abnormalities in patients who used oral hormone contraceptives for more than 5 years was 3.00. Our study showed that the first sexual intercourse before the age of 17 years of life for 2.14 times increases the risk of squamous intraepithelial lesions and squamous invasive cervical cancer (OR = 2.14; 95% CI: 1.0723-4.2821). The analysis of the data from our study also showed an association between squamous intraepithelial lesions and squamous invasive cervical cancer and dietary nutrition (OR = 2.11; 95% CI: 1.0218-4.3832). Conclusion: The analysis of the data of our study showed an association between squamous intraepithelial lesions and squamous invasive cervix cancer and HPV DNA infection, bacterial vaginosis, irregular gynecological controls, frequent vaginal discharge, early first sexual intercourse, cigarette smoking, long-term use of hormonal oral contraceptives and dietary nutrition.