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Language: search.filters.language.English (United States)Subject: search.filters.subject.weight loss

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    BODY FAT DISTRIBUTION AND LIPID PROFILE CHANGES AFTER WEIGHT LOSS – A CASE REPORT
    (Institute of Knowledge Management, 2019)
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    Janicevic Ivanovska, Danijela
    The aim of this study was to discover the relationship between body fat distribution and lipid profile changes after weight loss. In this case report following subject’s parameters were determined before and after weight loss of 12 kg: body mass index (BMI), body weight (BW), total, trunk and legs fat mass (FM) with dual energy xray absorptiometry (DXA) and their ratios legs/trunk and legs/total FM indexes of abdominal fat distribution. Lipid profile was also determined before and after weight loss: total cholesterol (TC), triglycerides (TG), HDL-C, LDL-C, LDL/HDL-C, TC/HDL-C. BW of 63 kg and BMI value of 28.74 kg/m2 before the weight loss lowered to 51kg and 22.55 kg/m2. The percentage difference between the change in BMI and BW was statistically not significant (p=0.782). Legs/total FM index value increase from 0.36 to 0.39 was significant (p<0.025). Legs/trunk FM index value increase from 0.67 to 0.76 was also significant (p<0.043). Legs, total and trunk FM had not significant reduction (p>0.05), but the percentage difference between their changes, during weight reduction was statistically significant (p=0.0001). TC, HDL-C, LDL-C, LDL/HDL-C, TC/HDL-C changes were also significant. The percentage difference between the change in BMI and BW to normal levels was statistically not significant, but the percentage difference between the changes in DXA indexes of visceral, abdominal obesity was significant and it was associated with significant reduction of atherogenic lipid profile indicating reduced atherogenic risk. These results confirmed that DXA measurements of abdominal fat distribution are very useful in studies related to obesityassociated disease risk.
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    Lipid profile changes relations to body fat distribution changes determined with dual-energy x-ray absorptiometry during the weight loss
    (Institute of Knowledge Management, 2019)
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    Janicevic Ivanovska, Danijela
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    Obesity and central body fat distribution are known risk factors for cardiovascular and metabolic diseases. Dual-energy x-ray absorptiometry (DXA) enables precise, accurate body composition and body fat distribution assessment and it measures and monitors body composition changes in obese patients undergoing weight loss. Obesity is associated with dyslipidemic profile. Low HDL-C levels are frequently associated with raised levels of plasma triglycerides and increased risk of cardiovascular disease and TG/HDL-C ratio may be a better predictor of insulin resistance and cardiovascular disease. LDL-C is one of the major culprits in the development of atherosclerotic heart disease and reduction of LDL-C levels is the primary target of therapy. The effect of weight loss on body fat distribution was examined through android, legs and ndroid/legs tissue and fat mass ratios indexes of central, abdominal obesity determined by DXA and their relationship with lipid profile hanges. The following parameters were determined before and after weight loss: body mass index (BMI), body weight (BW), android (A) and legs (L) tissue mass (TM) and fat mass (FM), their % with DXA, their ratios, indexes of abdominal fat distribution A/L-TM and TM% and A/L-FM and FM%, as well as lipid profile: total cholesterol (C), triglycerides (TG), HDL-C, LDL-C, LDL/HDL-C, C/HDL-C and TG/HDL-C. BW of 62.96±1.2 kg and BMI value of 28.98±0.78 kg/m2 before the weight loss lowered to 49.96±1.3 kg (p<0.012), and normal BMI 22.81±0.62 kg/m2 (p<0.012). A-TMf% value decrease from 50.41±1.7% to 29.55±1.34% after weight loss was significant (p<0.006) and A-FM% 49.92±1.2% decrease to 29.25±1.34% was also highly significant (p<0.005). A-TM 5.43±0.71 kg and A-FM 2.74±0.71 kg lowered to 3.76±0.25 kg and 1.11±0.12 kg after weight loss (p<0.05). L-TMf% 50.31±1.7% lowered to 35.2±2.12% (p<0.018) and L-TM 19.69±0.71 kg lowered to 16.15±0.55 kg (p<0.033). L-FM% 48.51±1.14% lowered to 33.8±1.98% (p<0.009) and L-FM 9.89±0.64 kg lowered to 5.68±0.16 kg (p<0.0002). A/L-TMf% value decrease from 1.01±0.07% to 0.84±0.014% and A/L-FM% value decrease from 1.03±0.04 to 0.87±0.07 were also significant (p<0.05). TG values decrease from 1.21±0.01 mmol/l to 0.83±0.07 mmol/l was significant (p<0.002) and C values decrease from 6.5±0.01 mmol/l to 5.43±0.37 mmol/l was also significant (p<0.05). LDL-C values 4.3±0.1 mmol/l lowered to 3.39±0.34 mmol/l (p<0.026) and TG/HDL-C ratio 0.73±0.01 lowered to 0.52±0.03 (p<0.011). This study showed that A-TMf% and A-FM% lowered highly significantly, indicating significant FM% reduction in android, abdominal TM. Atherogenic lipids TG, C and LDL-C and atherogenic index TG/HDL-C ratio lowered significantly. Also, it was confirmed that DXA indexes of central, abdominal obesity A/L-TM% and A/L-FM% were increased in overweight subjects before the weight loss and lowered highly significantly after the weight loss and increased A/L TM and A/L FM values lowered to normal values, indicating that normal BMI and BW reached after the weight loss were associated with normalized body fat distribution, and significant reduction of the atherogenic lipid profile indicating reduced atherogenic risk.
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    BODY FAT DISTRIBUTION CHANGES DURING WIGHT LOSS DETERMINED BY DXA ANDROID/GYNOID INDEXES OF ABDOMINAL OBESITY
    (Medical faculty, Ss Cyril and Methodius University Skopje, 2019)
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    Janicevikj Ivanovska, Daniela
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    The effect of weight loss on body fat distribution was examined through central obesity indexes (COI), which are android/gynoid tissue and fat mass ratios determined by dual-energy X-ray absorptiometry (DXA) and their relationship with lipid profile changes. The following parameters were determined before and after weight loss in 4 postmenopausal women: body mass index (BMI), body weight (BW), android (A) and gynoid (G) tissue mass (TM) and fat mass (FM) and their % with DXA, and their ratios as indexes of abdominal fat distribution COI1 (A/G-TM), COI2 (A/G-FM), COI3 (A/G-TMfat%) and COI4 (A/G-FM%), as well as lipid profile: total cholesterol (C), triglycerides (TG), HDL-C, LDL-C, LDL/HDL-C, C/HDL-C and TG/HDL-C. BW of 63±1.4 kg and BMI value of 29±0.65 kg/m2 lowered after the weight loss to 49±1.6 kg and normal BMI 22.62±0.74 kg/m2 (p<0.012). COI1 value decreased significantly from 0.5±0.01 to normal value 0.42±0.02 (p<0.003). COI2 value decreased significantly from 0.45±0.02 to normal value 0.34±0,02 (p<0.0004). COI3 value decrease from 0.95±0.026 to 0.74±0.012 was significant (p<0.0009) and COI4 value decrease from 0.95±0.01 to 0.74±0.02 was also significant (p<0.0001). Atherogenic indexes TG/HDL-C, LDL/HDL-C and C/HDL lowered significantly after the weight loss (p<0.002; p<0.03 and p<0.05) as well as TG, C and LDL values (p<0.001; p<0.01; p<0.01). It was confirmed that DXA indexes of central, abdominal obesity COI1 and COI2 were increased in overweight women before the weight loss and lowered significantly after the weight loss to normal values, indicating that normal BMI and BW reached after the weight loss were associated with normalized body fat distribution, and significant reduction of the atherogenic lipid profile indicating reduced atherogenic risk.