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Language: search.filters.language.English (United States)Subject: search.filters.subject.COVID-19

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    Paediatric appendicitis: international study of management in the COVID-19 pandemic
    (Oxfor academic, 2022-07-19)
    Paul van Amstel
    ;
    Ali El Ghazzaoui
    ;
    Nigel J Hall
    ;
    Tomas Wester
    ;
    Francesco Morini
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    REVIEW OF LUNG CANCER PATIENT CHARACTERISTICS AND TREATMENT STRATEGIES IN THE PANDEMIC COVID-19 YEAR Treated at the University Clinic of Radiotherapy and Oncology in Skopje
    (Macedonian Academy of Sciences and Arts, 2023-01)
    ;
    Dragan Jakimovki
    ;
    Vladimir Ristovski
    Introduction: It is estimated that delays in diagnosis due to the COVID-19 pandemic in North Macedonia could result in significant reductions in the number of potentially curative stages in lung cancer patients. Purpose: The aim of this study was to review patient characteristics and treatment strategies of lung cancer patients treated at the University Clinic of Radiotherapy and Oncology (UCRO), during the pre-pandemic year (from 1 of March 2019 to the end of February 2020) and the pandemic year (from 1 of March 2020 to the end of February 2021). Material: We analyzed eligible patients in the course of these two years according to patient characteristics and treatment strategies. Results: We have a record increasing in number of undefined lung cancer patients without any patho logical or histological conformation (11% pandemic year compared to 7% in the previous year), and an increased number of stage III and IV NSCLC patients in the pandemic year 449 (87%), in comparison to the pre-pandemic year of 403 (74%) patients. We have found a decreasing number of stage II NSCLC patients in the pandemic year 82 (13%) compared to 141 (26%) patients in the pre-pandemic year. We also note a decreasing number of patients with NSCLC operated on from 218 to 123 in the pandemic group. Due to frequent check-ups for COVID-19, we report an increasing number of early stage IA and stage IB patients, treated only by surgery. Conclusions: The strict screening and admittance criteria put in place by hospitals during the pandemic might have improved the oncology treatment course of lung cancer patients.
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    Differences of Oncology Treatment for Lung Cancer Patients in Pandemic COVID-19 Year: Our Clinical Experience
    (IASLC, 2022-08)
    ;
    Crvenkova, L
    Introduction: It is estimated that in North Macedonia delays in diagnosis due to COVID-19 pandemic, could result in significant reductions in the number of potentially curative stages in lung cancer patients. Methods: The aim of this study was to evaluate patient characteristics and treatment strategy of lung cancer patients treated at the University Clinic of Radiotherapy and Oncology (UCRO), during the pre-pandemic year (from 1 of March 2019 to the end of February 2020) compared to pandemic year (from 1 of March 2020 to the end of February 2021). We analyzed eligible patients in the course of these two years according to the patient characteristics and treatment strategies. Results: We have record increasing in number of undefined lung cancer patients without any pathological or histological conformation (11% pandemic year compared to 7 % in the previous year), and increased number of stage III and IV NSCLC patients in pandemic year 449 (87%) patients of NSCLC, in comparison to the pre-pandemic year 403 (74%). We have found decreasing number of stage II NSCLC patients in pandemic year 82 (13%) compared to 141 (26%) patients in pre-pandemic year and reporting decreasing number of operated patients with NSCLC from 218 to the 123 in the pandemic group. But we have to report increasing number of early stage IA and stage IB patients total 16, treated only by surgery. Conclusions: The strict screening and admittance criteria instilled by hospitals during the pandemic might have improved oncology treatment courses of the lung cancer patients. Keywords: COVID-19, lung cancer, pandemic year
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    C-REACTIVE PROTEIN AND NEUTROPHIL-LYMPHOCYTE RATIO AS PREDICTORS OF CLINICAL SEVERITY OF COVID-19
    (INSTITUTE OF PUBLIC HEALTH OF REPUBLIC OF NORTH MACEDONIA, 2021-11-12)
    Pandilov, Stefan
    ;
    Klenkoski, Suzana
    ;
    ;
    Mehmeti, Gazmend
    ;
    COVID-19 is an infectious disease that can manifest quite differently. In this study we examined the relationship between the value of serum CRP(C-reactive protein) andneutrophil-lymphocyte ratio (NLR) as predictor factors for the development of a severe clinical manifestation in COVID19 patients. Materials and methods: We followed 95 COVID-19 positive patients who were hospitalized at the University Clinic for Eye Diseases - COVID Center. We analyzed the initial laboratory parameters of white blood cells and CRP on admission of the patients and the results of laboratory analyses performed before they left the Clinic, or the last parameters before the lethal outcome in those patients who died. Several models of logistic regression were tested to analyze the predictive value of these markers of inflammation for lethal outcome in patients hospitalized for COVID-19. Results: Bivariate analysis demonstrated that the length of hospital stay was significantly shorter in patients with lethal outcome (p=0.001). The NLR was significantly higher in patients with lethal outcome at both times (p=0.005; and p=0.017). Leukocyte’s count (p=0.046, and p<0.001) and CRP (p=0.013,and p=0.005) were also significantly higher in patients with lethal outcome at both times. The increase on the NLR scale both at hospitalization and at discharge (or the last analysis before death) leads to increase in the odds of lethal outcome (T1:40.4% increased odds; T2:36% increased odds). Conclusion: CRP and NLR are laboratory parameters that can predict the severity of the clinical manifestation in patients with COVID-19.
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    Chloroquine and Hydroxychloroquine in Treatment of Coronavirus Disease-19
    (Scientific Foundation SPIROSKI, 2020-08-20)
    ;
    At present, we are facing coronavirus disease (COVID)-19 pandemic caused by the severe acute respiratory syndrome coronavirus-2 with several treatment choices and reports of different treatment outcomes. Chloroquine and hydroxychloroquine use for the management of severely ill patients started as a quite enthusiastic treatment option, following several small clinical trials, case series reports, public authorities, and media affirmation. However, the evidence we have so far is conflicting and some national societies and professional institutions implicate that we should wait for definite treatment recommendations until there are solid data for or against the use of these drugs. Until we have more powerful evidence in our hands, we should be aware of safety issues of the old drugs for the new application in the emergency state we are facing today with the COVID-19 pandemic. We performed a concise review of strengths, limitations, and awareness for chloroquine and hydroxychloroquine use for COVID-19 infection treatment based on the evidence the science has today.
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    Delayed Presentation of Acute ST Segment Elevation Myocardial Infarction Complicated with Heart Failure in the Period of COVID-19 Pandemic - Case Report
    (YuMed Text Publications, 2020-05-30)
    ;
    Oliver Bushljetikj
    ;
    Elena Grueva
    ;
    Background: Delayed provision of medical care to patients with acute chest pain who failed to seek medical attention on time due to fear from COVID-19 pandemic is a concern among health care professionals. Case summary: We report the case of a 47-year-old man with acute chest pain and dyspnea presenting with ST segment elevation myocardial infarction (STEMI). Patient did not seek medical attention on time due to fear from COVID-19 pandemic. Urgent echocardiography detected left ventricular function with ejection fraction (LVEF) of 35%. Percutaneous coronary intervention (PCI) with direct stenting to LAD as culprit lesion with additional stenting of right coronary artery (RCA) was performed. Patient was discharged clinically stable with heart failure. Discussion: COVID-19 outbreak is associated with significantly lower rate of hospital admissions of patients with STEMI. This worrisome fact might be accompanied by a substantial increase in early and late infarct-related morbidity and mortality. Health care providers and society together must appeal for increased awareness of seeking on-time medical care in case of acute chest pain.