Faculty of Medicine
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Item type:Publication, Association Between the Polymorphism of Angiotensin-Converting Enzyme Gene and Interleukin-1 Beta Gene and the Response to Erythropoietin Therapy in Dialysis Patients with Anemia(Walter de Gruyter GmbH, 2023-12); ; ; The polymorphism of the angiotensin-converting enzyme (ACE) gene and interleukin-1 beta (IL-1b) gene could be associated with resistance in the treatment of anemia in dialysis patients with recombinant human erythropoietin (rHuEPO). The aim of the study was to evaluate the association between the polymorphism of the ACE and IL-1b genes and the response to rHuEPO therapy in dialysis patients with anemia. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Attrition in Everyday Dental Clinical Practice(Macedonian Academy of Sciences and Arts/De Gruyter, 2024-12); ; Introduction Attrition, its prevention and therapy is a complex problem, with a multifactorial etiology. The aim of this paper is to examine the treatment of attrition in everyday dental clinical practice with the help of soft inserts. Material and method In this study, 30 patients were included, divided into two groups of 15 patients, the study and the control group. The examined patients had first degree of attrition diagnosed according to the Bardsley index, after which the condition was noted in four intervals: the initial situation, after 2, 4 and 6 months from the first visit. The research data were processed in Statistica for Windows 7.0 and SPSS version 20, and the same were presented graphically. Results In the study group with I degree of attrition, for p>0.05, no statistically significant difference was determined in the range of the Bardsley index between the four measurement times (Friedman Test: N=15; Chi-Square=7,200; df =3; p=0.0658). In the control group, for p<0.05, a significant difference was determined in the range of the Bardsley index between the four measured times (Friedman Test: N=15; Chi-Square=15.180; df=3; p=0.0017) with a significantly high value after 6 months. Discussion From the results obtained when comparing the study group in patients with I degree of attrition and the control group, a negative change from the parafunction bruxism was observed in 20% of the test group and 47% of the control group. The results of our research indicated that in patients with the first degree of attrition from the study group, soft dental inserts give significantly better results than untreated patients in the control group. This correlates with the research of Khayat N. et al. Conclusions From the results of the subjects in the group with I degree of attrition, we can conclude that the soft inserts has great efficiency as a means of management of this parafunction and therefore its application in daily therapy is recommended. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Small and large cell neuroendocrine carcinomas of the uterine cervix. A report of 10 cases.(Springer, 2005-08) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, THE PRINCIPLES OF ANISOMETROPIC AMBLYOPIA TREATMENT(Medical faculty, Ss Cyril and Methodius University in Skopje, 2017)Aim: Postoperative examination of the methods of treatment of anisometropic amblyopia without strabismus. Material and method:52 patients (from 6-11 years old) with anisometropic amblyopia without strabismus were included in this study .After the prescription of spectacles on the second visit, if there was no improvement of the visual acuity of the amblyopic eye and if there was no improvement of the visual acuity of the amblyopic eye and if there is still difference of two or more lines on the vision chart between the eyes, occlusion was prescribed for at least 6 hours a day of the sound eye. Resultats:28 patients from all 52,(53%) wee female and 24 patients (47%) were male. The age of the patients was average 9,2 years. Average visual acuity on the amblyopic eye at baseline was approximately 0,33 with correction before the patching treatment. There were 7 patients (13,7%) which resolved the amblyopia only with spectacles without patching. Average time for resolution of amblyopia was 8,2 months (range 3 to 16 months)The visual acuity of 20/20 achieved 43% patients with hypermetropy anisometropic amblyopic eye and 3,8% patients with astigmatic anisometropic amblyopia. Conclusion: Early screening of preschool children for detection of anisometropic and other types of amblyopia is important for the on time treatment of the amblyopic eye. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, CLINICAL MANIFESTATION AND PROGRESSIVE SENSORINEURAL HEARING LOSS IN THE PATIENTS WITH RETINITIS PIGMENTOSA(University Ss. Cyril and Methodius, Medical Faculty in Skopje, 2018); Jakimovska DitkaRetinitis pigmentosa (RP) is an inherited retinal disorder characterized by progressive loss of photoreceptors and retinal pigment epithelium. RP is characterized by impaired night vision, slowly progressive peripheral to central visual field loss, and often a decline in visual acuity. Aim: Clinical examination of patients with retinitis pigmentosa. Material and method: From January 2006 to December 2017, 24 patients with retinitis pigmentosa (RP) were examined. The visual acuity, slip lamp and fundus examination, visual field, red cam investigation, FFA and OCT of the posterior segment were done. In the patients, the hearing condition was examined with vestibular testing. Most of the cases are still followed in the University Eye Clinic in Skopje. Results: Clinical symptoms, FFA angiograms, OCT slides and visual fields results are discussed. All 24 patients showed either arteriolar attenuation, retinal bone-spicule pigmentation and/or waxy disc pallor, which result in progressive vision loss. 18 patients showed familiar characteristic presentation of the disease and 6 patients showed sporadic cases. Myopia was found in 62,5% (15 patients) and keratoconus in 25% (6 patients). On the posterior segment, fundus, drusen of the PNO in 20,8% (5 patients) and macular abnormalities (macular edema, macular atrophy, cellophane maculopathy) in 16,7% (4 patients) was observed. Vitreous opacification 66,7% (16 patients) and cataract 62,5% (15 patients) were present and lead to additional deterioration of vision acuity. The open-angle glaucoma was found in 12,5% (3 patients). The results of the sensorineural hearing tests suggest that most of the patients with RP have difficulty communicating and socially inadequate hearing. Sensorineural hearing loss was observed in 62,5% (15 patients). In these 15 patients with hearing loss, alteration of vestibular function of peripheral type was found in 80% (12 patients) and of mixed type in 20% (3 patients). Conclusion: Treating the retinitis pigmentosa visual and hearing manifestations, as well as continuous following of the RP-affected patients is vital for preserving the vision acuity, auditory acuity and quality of life. Patients with neurosensory hearing loss of unknown genesis should necessarily undergo a preliminary eye examination to confirm or exclude the RP diagnosis. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, MOOREN’S ULCER –A CASE REPORT(University Ss. Cyril and Methodius, Medical Faculty in Skopje, 2020)Introduction: Mooren’ s ulcer is a painful, relentless, chronic ulcerative keratitis that starts peripherally and progresses circumferentially and centrally. Mooren’s ulcer is a rare corneal ulcer and it is important to be recognized early and treated properly. The different clinical symptoms and local sings and presentation (unilateral or bilateral) of corneal Mooren’s ulcer, separate this entity in two groups, benign-limited form and aggressive or progressive form with severe symptoms and morbidity, high tendency for recurrence and increased risk of unsuccessful treatment. Case presentation: A case of Mooren’s ulcer in a female patient 65-year-old is present. She was treated at the University Clinic for eye disease in Skopje after one month of leech extraction of her left eye. The patient came at the Clinic as urgent case with melting syndrome of the peripheral left cornea. Slit lamp examination of the anterior segment confirm the Mooren’s ulcer clinical characteristic such as crescent-shaped, peripheral half-circumferential corneal ulcer which start from the limbus with gray infiltrated margin. The sclera around was not involved. The patient complained of pain in her eye and blurred vision. Red eye, foreign body sensation and epiphora were present also. Corneal and conjunctival culture was taken. The lacrimal canal was examined with the straight lacrimal cannula on a 3 ml saline –filled syringe inserted into the lower canaliculus. There was no obstruction in the upper or lower or the common canaliculus. The lacrimal canaliculus was without secretion. Conclusion: A proper, rigorous and early treatment of the Mooren’s ulcer is important for improvement of the local status of this peripherally circumferential melting syndrome. The leech extraction from the patient left eye, a month before, maybe is one of the key factors in the pathogenesis of Mooren’s ulcer. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, CASE REPORT: REACTIVATION OF CONGENITAL OCULAR TOXOPLASMOSIS IN AN IMMUNOCOMPETENT PATIENT AFTER RECEIVING MEASLES(Faculty of Medicine, University Ss. Cyril and Methodius in Skopje, 2022-08-31); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Anxiety in acute myocardial infarction survivors(SHMSHM / AAMD, 2020); ; Sevime Sallahi PasholliIntroduction :Data obtained in some studies indicate that somatic disorders, in a certain percentage, are associated with a mental health problems, whether in a form of two co-existent diseases, whether psychological problems are only associated symptoms and/or response to somatic disease. Anxiety is psychological symptoms frequently encountered in patients suffering from acute myocardial infarct (AMI). The AIM of our study was to determine the percentage of anxiety in two investigated groups of patients with myocardial infarction and to determinate the correlation between socio-demographic characteristic and level of anxiety in survivors of AMI. Material and methods: The study was designed as observation cross-section including 80 patients treated at the university Clinic of Cardiology Skopje , observed as 2 groups : group 1 was presented with patients during hospitalization for AMI, and 2 group were patients survivors after 6 months of the acute coronary event. Anxiety status was assessed using HAMA scale. Results : The two groups of patients did not show significant difference according distribution of gender , smoking , physical activity, stress , age, mean HAMA , BMI , age of education and marital status . In the first group 21 (51,2%) of patients have anxiety symptoms while in second group 25 (64,1%). In our study acute MI was more prevalent in a men but women had a higher risk of anxiety disorders 27,3% v.s (22,7%). In examination groups the anxiety (HAMA score) was positive correlate with socio-demographic and clinical parameters where only we got negative correlate between anxiety with marital status and BMI in the first group and negative correlation with married status, smoking status, physical activity, stress and BMI in the second group . .Conclusion: The results in our study showed indicative representation of anxiety in patients survivors of AMI. So screening for anxiety in all AMI patients is also important because this patients should be treated differently than those who are not anxiety. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, DEPRESSION AND DIABETES(Institute of Knowledge Management, 2020); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, QUALITY OF LIFE, FORCED EXPIRATORY VOLUME IN ONE SECOND AND BODY MASS INDEX IN PATIENTS WITH COPD, DURING THERAPY FOR CONTROLLING THE DISEASE(Macedonian Academy of Sciences and Arts, 2009); Stevcevska G.Abstract: Patients with chronic obstructive pulmonary disease (COPD) are characterized by an impaired lung function and limited exercise tolerance. Medication and rehabilitation programmes are generally directed towards relief of symptoms and improvement of lung function and exercise tolerance. 130 patients were included in the examination with diagnosed chronic obstructtive pulmonary disease, stable form, 114 male and 16 female, of whom 121 were smokers and 9 were non-smokers. Inclusive criteria were FEV1 < 50% from predicted (with moderate and severe level of the disease), the relation FEV1/FVC < 70%, the test of reversibility with β2-agonist < 15%. The patients were followed up for 18 months. They were evaluated at the start, and then at the end of the study. During the examination 9 patients were excluded because they did not obey recommendations of the examination, and three patients died during the examination. At the end of our study 77 patients in group I, 66 male and 11 female, were evaluated, and 41 patients, 35 male and 6 female, in group II. The patients were divided on the basis of BMI (body mass index), group I with BMI from 21 to 28 kg/m2 and group II with BMI < 21 kg/m2 . The mean age of the patients was 63 ± 7.2 years in group I, and 68 ± 8.3 in group II. The values of FEV1 at the start were 1.33 ± 0.35L (43 ± 8.1%) in group I, and 0.89 ± 0.27 L (28 ± 7.9%) in group II. Both were significantly lower in group II (p < 0.001). At the end of the study the values of FEV1 were lower in both groups than at the start (Fig. 1). At the start of the study SGRQ scores in group I were significantly lower (p < 0.001) than in group II. This indicated a better quality of life in patients with BMI from 21 to 28 kg/m2 . The SGRQ scores at the end of the study were also significantly lower in group I (p < 0.001). And they were lower than at the start in both groups, indicating a better quality of life in patients with COPD after18 months’ regular use of therapy (Fig. 2). The values of Pearson’s coefficient r = -0.49 (p < 0.05) in group I and r = -0.35 (0.05) in group II, shows that between these two variables there is an indirect, or negative correlation; lower values of FEV1 are associated with higher SGRQ total scores. It can be concluded that regular use of therapy for controlling the disease leads to improved quality of life in COPD patients, which is not associated with improvement in lung function. Patients with malnutrition (BMI < 21kg/m2 ) have lower values of FEV1, and they have higher SGRQ scores of quality of life. High levels of SGRQ scores are associated with lower values of FEV1. Key words: COPD, therapy, quality of life, forced expiratory volume in one second, body mass index.