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Language: search.filters.language.EnglishSubject: search.filters.subject.squamous cell abnormalities

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    Human papillomavirus infections in women with and without squamous cell abnormalities of the uterine cervix
    (Centre for Evaluation in Education and Science, 2019)
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    Dabeski, Ana
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    Trajanova, Milka
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    Todorovska, Irena
    Background: Human papillomavirus infections are one of the most common sexually transmitted infections with viral aetiology. The aim of the study was to confirm the existence of an association between human papillomavirus infection and squamous cell abnormalities of the uterine cervix. Methods: Cohort study, conducted in the period from January 2017 to June 2018 of 768 sexually active women, age groups of 20 to 59 years, divided into two groups: examined and control, who came to their annual gynaecological exam at University Clinic for Gynaecology and Obstetrics in Skopje. In all patients was done human papillomavirus-deoxyribonucleic testing. Human papillomavirus detection and typing was done using a polymerase chain reaction and reverse hybridisation. Results: Data analysis showed an association between human papillomavirus infection and squamous cell abnormalities of the uterine cervix (p=0.00001). Human papillomavirus infection was detected in 22.91% of all patients, in 75.00% of patients with abnormal cervical cytology and in 12.50% of patients with normal cervical cytology. A single human papillomavirus infection was detected in 13.67% of all patients (in 59.66% of human papillomavirus positive patients). Mixed human papillomavirus infection was detected in 9.24% of all patients (in 40.34% of human papillomavirus positive patients). Human papillomavirus type 16 was the most common genotype with 40.91%. Conclusion: This study confirmed that there is an association between human papillomavirus infection and squamous cell abnormalities of the uterine cervix and the young population under the age of 30 years is the most affected.
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    Correlation between cytopathology and histopathology in women with squamous cell abnormalities of the uterine cervix
    (SHMSHM / AAMD, 2017)
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    Objective: The aim of the study was to correlate the results of cervical cytology and cervical biopsy in women with squamous cell abnormalities of the uterine cervix. Materials and Methods: This comparative retrospective study was conducted in a series of 184 sexually active women, aged 20 to 60, who came to their annual gynecological exam at the University Clinic for Gynecology and Obstetrics in Skopje between September 2015 and March 2016. In all 184 patients with cytologically diagnosed squamous cell abnormalities of the uterine cervix, a colposcopic cervical biopsy with endocervical curettage for histopathological analysis was taken, with was analyzed at the University Clinic for Radiotherapy and Oncology in Skopje. The results of the liquid-based cytology smears and cervical biopsies were compared to evaluate the diagnostic agreement between the cytology findings and the biopsies. Results: Cytopathologically, there were 118 (64.13%) ASC-US, 22 (11.96%) LSIL, 38 (20.65%) HSIL and 6 (3.26%) invasive carcinoma cases. Histopathologically, there were 108 (58.70%) non-neoplastic lesions, 24 (13.04%) LGSIL cases, 42 (22.83%) HGSIL cases and 10 (5.43%) invasive squamous cell carcinomas. Including all squamous cell abnormalities, the sensitivity of the smear test in low-grade and higher grade lesions was 58.70% (108/184) and the false positivity was 41.30% (76/184). Excluding ASC-US lesions, the sensitivity of the smear test was 78.80% (52/66) and the false positivity was 21.21% (14/66). After evaluating cervical cytopathological correlation the positive predictive value was found to be 100% (6/6) in invasive carcinoma, 68.42% (26/38) in HGSIL and 31.82% (7/22) in LGSIL. Conclusions: The high sensitivity of the cervical smear test for high-grade squamous lesions shows that it is an effective screening test for cervical cancer and precursor lesions.